Eumetopias jubatus (Steller sea lion): 114211178 Help Entry 114211178         CDS       T07240                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju00230   Purine metabolism eju01100   Metabolic pathways eju01522   Endocrine resistance eju04015   Rap1 signaling pathway eju04020   Calcium signaling pathway eju04022   cGMP-PKG signaling pathway eju04024   cAMP signaling pathway eju04062   Chemokine signaling pathway eju04072   Phospholipase D signaling pathway eju04081   Hormone signaling eju04082   Neuroactive ligand signaling eju04114   Oocyte meiosis eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04261   Adrenergic signaling in cardiomyocytes eju04270   Vascular smooth muscle contraction eju04371   Apelin signaling pathway eju04540   Gap junction eju04611   Platelet activation eju04713   Circadian entrainment eju04714   Thermogenesis eju04720   Long-term potentiation eju04723   Retrograde endocannabinoid signaling eju04724   Glutamatergic synapse eju04725   Cholinergic synapse eju04727   GABAergic synapse eju04742   Taste transduction eju04750   Inflammatory mediator regulation of TRP channels eju04911   Insulin secretion eju04912   GnRH signaling pathway eju04913   Ovarian steroidogenesis eju04914   Progesterone-mediated oocyte maturation eju04915   Estrogen signaling pathway eju04916   Melanogenesis eju04918   Thyroid hormone synthesis eju04921   Oxytocin signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04925   Aldosterone synthesis and secretion eju04926   Relaxin signaling pathway eju04927   Cortisol synthesis and secretion eju04928   Parathyroid hormone synthesis, secretion and action eju04934   Cushing syndrome eju04935   Growth hormone synthesis, secretion and action eju04970   Salivary secretion eju04971   Gastric acid secretion eju04972   Pancreatic secretion eju04976   Bile secretion eju05032   Morphine addiction eju05163   Human cytomegalovirus infection eju05166   Human T-cell leukemia virus 1 infection eju05200   Pathways in cancer eju05207   Chemical carcinogenesis - receptor activation eju05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     114211178 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     114211178 (ADCY8)    04371 Apelin signaling pathway     114211178 (ADCY8)    04020 Calcium signaling pathway     114211178 (ADCY8)    04072 Phospholipase D signaling pathway     114211178 (ADCY8)    04024 cAMP signaling pathway     114211178 (ADCY8)    04022 cGMP-PKG signaling pathway     114211178 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     114211178 (ADCY8)    04081 Hormone signaling     114211178 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     114211178 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     114211178 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     114211178 (ADCY8)    04062 Chemokine signaling pathway     114211178 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     114211178 (ADCY8)    04923 Regulation of lipolysis in adipocytes     114211178 (ADCY8)    04912 GnRH signaling pathway     114211178 (ADCY8)    04913 Ovarian steroidogenesis     114211178 (ADCY8)    04915 Estrogen signaling pathway     114211178 (ADCY8)    04914 Progesterone-mediated oocyte maturation     114211178 (ADCY8)    04921 Oxytocin signaling pathway     114211178 (ADCY8)    04926 Relaxin signaling pathway     114211178 (ADCY8)    04935 Growth hormone synthesis, secretion and action     114211178 (ADCY8)    04918 Thyroid hormone synthesis     114211178 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     114211178 (ADCY8)    04916 Melanogenesis     114211178 (ADCY8)    04925 Aldosterone synthesis and secretion     114211178 (ADCY8)    04927 Cortisol synthesis and secretion     114211178 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     114211178 (ADCY8)    04270 Vascular smooth muscle contraction     114211178 (ADCY8)   09154 Digestive system    04970 Salivary secretion     114211178 (ADCY8)    04971 Gastric acid secretion     114211178 (ADCY8)    04972 Pancreatic secretion     114211178 (ADCY8)    04976 Bile secretion     114211178 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     114211178 (ADCY8)    04727 GABAergic synapse     114211178 (ADCY8)    04725 Cholinergic synapse     114211178 (ADCY8)    04720 Long-term potentiation     114211178 (ADCY8)    04723 Retrograde endocannabinoid signaling     114211178 (ADCY8)   09157 Sensory system    04742 Taste transduction     114211178 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     114211178 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     114211178 (ADCY8)    04213 Longevity regulating pathway - multiple species     114211178 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     114211178 (ADCY8)    04714 Thermogenesis     114211178 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     114211178 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     114211178 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     114211178 (ADCY8)    05163 Human cytomegalovirus infection     114211178 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     114211178 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     114211178 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     114211178 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     114211178 (ADCY8) Enzymes [BR:eju01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      114211178 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  114211178 NCBI-ProteinID:  XP_027961469 LinkDB All DBs Position Unknown AA seq 1252 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG SGSRGSGKASDPRGGGPDHHAAQLSGDSALPLYSLGPGERAHSTGGTKVFPERSGSGSGS GSGGGGDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVVLQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKE ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKHLLNENNNTGIIKGHYNRRTLLTPSGPEPGAQAEGTDKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctgagcggcagcgaggaactctacactatccacccg acgcccccggccggcgacggcgggagcggctcgcggccgcagcggctgttgtggcagacg gcggtgaggcacatcaccgagcagcgcttcattcatgggcatcggggcagcggcggcggc agcgggagcagaggctccggcaaagcctcggaccctagaggcggcggccccgaccatcac gcggcgcagctctccggcgactcggcgctgcccctctactcgctgggccccggggagaga gcgcacagcactggtggcaccaaagtcttcccggaacgcagcgggagcggcagcggcagc ggcagcgggggcggtggcgatctgggcttcctgcacctcgactgcgccccaagcaactcg gatttcttcctcagtgggggctatagctaccgaggggtcattttccccactctgcgcaac tctttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaatgtactggacgtgctgaccaaactcactctcttggtcctc cacttgagcctggcctcggccccgatggacccgctcaagggcatcctcctgggcttcttc actggcatcgaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcac acgtacctgcagtatagcggcgtagtcacttgggtggccatgaccacccagatcttggca gcaggcctcggctacgggcttctgggtgatggcatcggctacgttctcttcacgctgttt gccacctacagcatgctgccgctgccgctaacctgggccatcctggccggcctgggcacc tcgctgctgcaggtggtcctgcaggtggtcatcccccggctagcggtcatttccatcaac caggttgtggcccaggcagtgttattcatgtgtatgaacacagctggaatcttcatcagc tacctgtcagaccgggcccagcgccaagccttcctggagacgcggaggtgtgtggaggcc aggctacgcctggagacggaaaaccaaagacaggagcggctcgtgctctctgtgctcccc cgctttgtcgtcctggaaatgatcaacgacatgaccaatgttgaagacgagcacttgcag caccagttccatcggatctacatccaccgctacgagaacgtcagtattctttttgcagat gttaaaggatttaccaacctctccacgaccttgtccgcccaggagctggtccggatgctc aacgagctctttgccagatttgatcgactggcccatgagcatcattgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttcccgagccccgccaggaccacgcc cactgctgcgttgaaatgggcctcagcatgatcaaaactatcaggtatgtgaggtcaagg acgaagcatgatgtggacatgcggattggaatccactcgggctcagtgctgtgtggagtg ttgggcctgcggaagtggcagtttgatgtctggtcctgggatgtggacattgcgaacaaa ctagaatctggaggaatccctgggaggattcacatttccaaagccacgctggactgcctc aacggtgactataacgtagaagagggtcatggtaaagagagaaacgaattcttgaggaag cataacatagagacctatttgattaagcagcctgaggagagtctgctgtcgttgcccgaa gacattgtcaaggaatcggtgagctcctcagacaggagaaacagtggggcgacattcaca gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtctgtgca tttattgttcttctatttatcacggcgatacaaagtttgcttccttcttcaagggtgatg ccaatggccatccagttttccatcctgattatgctgcactcggctctggtcctcatcacc acagcagaggattataagtgtttgcccctcgtcctccggaaaacttgctgttggattaac gagacctatttggcccggaacgtcatcatctttgcatccatcttgattaacttcctgggc gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact ttcaattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttcacc ggggtgctggccatggtgacctgtgcagtcttcctccgcctgaactctgtcctgaagctg gcggtgctgctgattatgatcgccatctacgccctgctgaccgagaccatctatgcgggc ctctttctgcgctacgacaacctgaaccacagtggagaagatttcctggggacaaaagag gcctcactgctgctgatggccatgttcctccttgctgtgttctaccatggacagcagctg gagtacacagcccgccttgacttcctttggcgagtacaagccaaagaggagatcaatgag atgaaggagctgagggaacacaacgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaatgaggagctgtactctcaatcctatgat gccgtcggagtgatgttcgcctccatcccggggtttgcagacttttactcgcagactgaa atgaataaccaaggagtggaatgcctgcgcctgctgaatgagatcattgctgacttcgat gagctgcttggcgaagaccggttccaagacattgaaaagattaagaccattggcagcacc tacatggccgtgtcaggcctgtcccctgaaaaacagcaatgtgaagacaagtggggacat ttgtgcgccctggccgacttctccctcgccctgaccgagagcatacaggagatcaacaag cattccttcaacaatttcgaactccggattggcatcagccacggctcggtggtagctggc gttatcggcgctaagaaaccacagtatgacatttggggcaaaactgtgaacctggcaagt cgaatggacagcacaggggtcagcggcaggatccaagtccccgaggagacctatctcatc ctgaaggaccagggctttgcctttgactaccgaggggagatctacgtgaagggcatcagt gaacaggaaggaaaaatcaaaacgtactttctgctgggaagagtccaacccaacccattc atcctgcccccgagaagactgcccgggcagtactccttggccgcggtcgtcctgggcctt gtccagtccctgaacaggcaaaggcagaagcacctcctcaacgagaacaacaacacgggg attatcaagggtcattacaaccggcggactttgttgacacccagcgggccagagcctgga gcccaagccgaaggcaccgacaagtccgatttgccataa

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