KEGG   Eumetopias jubatus (Steller sea lion): 114223136
Entry
114223136         CDS       T07240                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju00562  Inositol phosphate metabolism
eju01100  Metabolic pathways
eju01521  EGFR tyrosine kinase inhibitor resistance
eju04012  ErbB signaling pathway
eju04014  Ras signaling pathway
eju04015  Rap1 signaling pathway
eju04020  Calcium signaling pathway
eju04062  Chemokine signaling pathway
eju04064  NF-kappa B signaling pathway
eju04066  HIF-1 signaling pathway
eju04070  Phosphatidylinositol signaling system
eju04072  Phospholipase D signaling pathway
eju04360  Axon guidance
eju04370  VEGF signaling pathway
eju04517  IgSF CAM signaling
eju04613  Neutrophil extracellular trap formation
eju04650  Natural killer cell mediated cytotoxicity
eju04658  Th1 and Th2 cell differentiation
eju04659  Th17 cell differentiation
eju04660  T cell receptor signaling pathway
eju04664  Fc epsilon RI signaling pathway
eju04666  Fc gamma R-mediated phagosome formation
eju04670  Leukocyte transendothelial migration
eju04722  Neurotrophin signaling pathway
eju04750  Inflammatory mediator regulation of TRP channels
eju04919  Thyroid hormone signaling pathway
eju04933  AGE-RAGE signaling pathway in diabetic complications
eju04935  Growth hormone synthesis, secretion and action
eju05012  Parkinson disease
eju05022  Pathways of neurodegeneration - multiple diseases
eju05135  Yersinia infection
eju05167  Kaposi sarcoma-associated herpesvirus infection
eju05170  Human immunodeficiency virus 1 infection
eju05171  Coronavirus disease
eju05200  Pathways in cancer
eju05205  Proteoglycans in cancer
eju05206  MicroRNAs in cancer
eju05214  Glioma
eju05223  Non-small cell lung cancer
eju05225  Hepatocellular carcinoma
eju05231  Choline metabolism in cancer
eju05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
eju05417  Lipid and atherosclerosis
Module
eju_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:eju00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114223136 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114223136 (PLCG1)
   04014 Ras signaling pathway
    114223136 (PLCG1)
   04015 Rap1 signaling pathway
    114223136 (PLCG1)
   04370 VEGF signaling pathway
    114223136 (PLCG1)
   04064 NF-kappa B signaling pathway
    114223136 (PLCG1)
   04066 HIF-1 signaling pathway
    114223136 (PLCG1)
   04020 Calcium signaling pathway
    114223136 (PLCG1)
   04070 Phosphatidylinositol signaling system
    114223136 (PLCG1)
   04072 Phospholipase D signaling pathway
    114223136 (PLCG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    114223136 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    114223136 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    114223136 (PLCG1)
   04660 T cell receptor signaling pathway
    114223136 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    114223136 (PLCG1)
   04659 Th17 cell differentiation
    114223136 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    114223136 (PLCG1)
   04666 Fc gamma R-mediated phagosome formation
    114223136 (PLCG1)
   04670 Leukocyte transendothelial migration
    114223136 (PLCG1)
   04062 Chemokine signaling pathway
    114223136 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    114223136 (PLCG1)
   04919 Thyroid hormone signaling pathway
    114223136 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    114223136 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114223136 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    114223136 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114223136 (PLCG1)
   05206 MicroRNAs in cancer
    114223136 (PLCG1)
   05205 Proteoglycans in cancer
    114223136 (PLCG1)
   05231 Choline metabolism in cancer
    114223136 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114223136 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    114223136 (PLCG1)
   05214 Glioma
    114223136 (PLCG1)
   05223 Non-small cell lung cancer
    114223136 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    114223136 (PLCG1)
   05171 Coronavirus disease
    114223136 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114223136 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    114223136 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    114223136 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    114223136 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114223136 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114223136 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114223136 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eju04131]
    114223136 (PLCG1)
Enzymes [BR:eju01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     114223136 (PLCG1)
Membrane trafficking [BR:eju04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    114223136 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    114223136 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG PH SH3_1 C2 EF_HAND_1_PLCG SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 114223136
NCBI-ProteinID: XP_027977695
LinkDB
Position
Unknown
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GEQPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMFSFLRDPLREVEEPYFNLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFSMSLRERGSDASGQLFHGRAREGSFEARYQQPFEDF
RISHEHLADQSDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgtgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggaacggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggag
atccgccctgggaagacctcacgggattttgatcgctaccaagaagaccctgctttccga
ccagaccagtcacactgctttgtcatcctgtatggaatggaattccgcctgaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggtttaacatggctg
atggaggacacattgcaggcagccacacctctgcagattgagaggtggcttcggaagcag
ttctactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctatgggcagtttgctcagctctaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggca
ggggagcagccagagctctgtcgtgtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgttcagcttc
cttcgagatcccttgcgagaagttgaagaaccatacttcaacctggacgagtttgttacc
tttctgttctccaaagagaacagtgtgtggaactcgcagctggatgcagtgtgcccggac
accatgaacaaccctctctcccactactggatctcttcctcccacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctagaagcctacgctcgctgcctgcgaatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
ggacacacccttaccactaagatcaagttctccgacgttctgcacaccatcaaggagcat
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacacactccttaccaag
cccgtggacattgccgcggatgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagaaggcagtgcctacgaagaggtgcctacatcagtgatg
tactccgagaatgatatcagcaactccatcaagaatggcattctctacctggaagacccc
gtgaaccacgagtggtacccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacggagctgcactccagtgagaagtggttccatgggaagctcggggcggggcgggat
ggacggcacatcgccgagcgcctgctcaccgagtattgcatcgagaccggggcccctgac
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactacaccctctctttctgg
aggaacgggaaagtccagcactgccggatccactcccggcaggacgctggggcccccaag
ttctttttgacagacaacttggtctttgactcgctctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgctagcctgaccagagctcaggccgagcac
atgctgatgcgtgtcccccgggacggggccttcctggtgagaaaacggaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcattgccgtgtccagcaggag
ggccagacggtgatgctgggcaactcggagtttgacagcctcgtggacctcatcagctac
tatgagaagcatccactgtaccgcaaaatgaagctgcgctatcccatcaatgaggaggcg
ctggagaagattggcactgcggagcctgattatggagccctgtatgagggacgcaaccct
ggcttctacgtggaggcaaatcctatgcctactttcaagtgtgcggtcaaagccctcttt
gactacaaggcacagagggaggacgagctgacattcacgaagagcgccatcatccagaat
gtggagaagcaagatggcggctggtggcggggggactatgggggaaagaagcagctgtgg
tttccgtccaactacgtggaggagatggtcagccctgcagccctggagcccgagagggag
cacttggacgagaacagccccctgggggacttgctccggggggtcttggatgtgccggct
tgtcagatagccatccgccccgagggcaagaacagccggctcttcgtcttctccatcagc
atggcttcggtggcacactggtccttggacgtcgctgctgactcccaggaggagctgcag
gactgggtgaagaagatccgagaggtggcccagacggcagacgccaggctcacggagggg
aagatgatggagcgcaggaagaagatcgccctggagctctctgagctggttgtctactgt
cggcccgttcccttcgatgaagagaagattggcacggaacgtgcctgctaccgggacatg
tcatcctttccggagacgaaggcggagaaatacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctacagctctcccgcatctaccccaagggccagcggctggactcc
tccaactacgaccccttgcccatgtggatctgcggcagtcagctcgtggccctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcctggccggcggccactgt
ggctatgtgctgcagccaagcaccatgcgggatgaggcctttgatccctttgacaagagc
agcctccgaggtctggagccatgtgccatctgcattgaggtgctgggggcccggcacctg
ccaaagaacggccgaggcatcgtgtgtccttttgtggagattgaggtggccggagcagag
tatgacagcatcaagcagaagacagagtttgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagcaacccggaattcgcctttctgcgctttgtg
gtgtatgaggaagacatgttcagtgaccagaacttcctggctcaggctacctttccagtg
aaaggcctgaagacaggatacagagccgtgcctttgaagaacaactacagtgaggacctg
gagctggcctccctgctcgtcaagatcgatgttttccctgccaagcaggagaacggggac
ctcagtcccttcagtatgtctctgcgggagaggggctctgatgcttcgggccagctcttt
catggccgggcccgggaaggttcctttgaagcccgctaccaacagccgtttgaggacttc
cgcatctcccacgagcatctggcagaccagtctgacagtcgggaacggagggccccacga
cggactcgggtcaacggagacaaccgcctctag

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