Eumetopias jubatus (Steller sea lion): 114223681 Help Entry 114223681         CDS       T07240                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju00230   Purine metabolism eju01100   Metabolic pathways eju01522   Endocrine resistance eju04015   Rap1 signaling pathway eju04020   Calcium signaling pathway eju04022   cGMP-PKG signaling pathway eju04024   cAMP signaling pathway eju04062   Chemokine signaling pathway eju04072   Phospholipase D signaling pathway eju04081   Hormone signaling eju04082   Neuroactive ligand signaling eju04114   Oocyte meiosis eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04261   Adrenergic signaling in cardiomyocytes eju04270   Vascular smooth muscle contraction eju04371   Apelin signaling pathway eju04540   Gap junction eju04611   Platelet activation eju04713   Circadian entrainment eju04714   Thermogenesis eju04723   Retrograde endocannabinoid signaling eju04724   Glutamatergic synapse eju04725   Cholinergic synapse eju04727   GABAergic synapse eju04750   Inflammatory mediator regulation of TRP channels eju04911   Insulin secretion eju04912   GnRH signaling pathway eju04913   Ovarian steroidogenesis eju04914   Progesterone-mediated oocyte maturation eju04915   Estrogen signaling pathway eju04916   Melanogenesis eju04918   Thyroid hormone synthesis eju04921   Oxytocin signaling pathway eju04922   Glucagon signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04925   Aldosterone synthesis and secretion eju04926   Relaxin signaling pathway eju04927   Cortisol synthesis and secretion eju04928   Parathyroid hormone synthesis, secretion and action eju04934   Cushing syndrome eju04935   Growth hormone synthesis, secretion and action eju04970   Salivary secretion eju04971   Gastric acid secretion eju04972   Pancreatic secretion eju04976   Bile secretion eju05032   Morphine addiction eju05163   Human cytomegalovirus infection eju05166   Human T-cell leukemia virus 1 infection eju05200   Pathways in cancer eju05207   Chemical carcinogenesis - receptor activation eju05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     114223681 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     114223681 (ADCY2)    04371 Apelin signaling pathway     114223681 (ADCY2)    04020 Calcium signaling pathway     114223681 (ADCY2)    04072 Phospholipase D signaling pathway     114223681 (ADCY2)    04024 cAMP signaling pathway     114223681 (ADCY2)    04022 cGMP-PKG signaling pathway     114223681 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     114223681 (ADCY2)    04081 Hormone signaling     114223681 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     114223681 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     114223681 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     114223681 (ADCY2)    04062 Chemokine signaling pathway     114223681 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     114223681 (ADCY2)    04922 Glucagon signaling pathway     114223681 (ADCY2)    04923 Regulation of lipolysis in adipocytes     114223681 (ADCY2)    04912 GnRH signaling pathway     114223681 (ADCY2)    04913 Ovarian steroidogenesis     114223681 (ADCY2)    04915 Estrogen signaling pathway     114223681 (ADCY2)    04914 Progesterone-mediated oocyte maturation     114223681 (ADCY2)    04921 Oxytocin signaling pathway     114223681 (ADCY2)    04926 Relaxin signaling pathway     114223681 (ADCY2)    04935 Growth hormone synthesis, secretion and action     114223681 (ADCY2)    04918 Thyroid hormone synthesis     114223681 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     114223681 (ADCY2)    04916 Melanogenesis     114223681 (ADCY2)    04925 Aldosterone synthesis and secretion     114223681 (ADCY2)    04927 Cortisol synthesis and secretion     114223681 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     114223681 (ADCY2)    04270 Vascular smooth muscle contraction     114223681 (ADCY2)   09154 Digestive system    04970 Salivary secretion     114223681 (ADCY2)    04971 Gastric acid secretion     114223681 (ADCY2)    04972 Pancreatic secretion     114223681 (ADCY2)    04976 Bile secretion     114223681 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     114223681 (ADCY2)    04727 GABAergic synapse     114223681 (ADCY2)    04725 Cholinergic synapse     114223681 (ADCY2)    04723 Retrograde endocannabinoid signaling     114223681 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     114223681 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     114223681 (ADCY2)    04213 Longevity regulating pathway - multiple species     114223681 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     114223681 (ADCY2)    04714 Thermogenesis     114223681 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     114223681 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     114223681 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     114223681 (ADCY2)    05163 Human cytomegalovirus infection     114223681 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     114223681 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     114223681 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     114223681 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     114223681 (ADCY2) Enzymes [BR:eju01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      114223681 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  114223681 NCBI-ProteinID:  XP_027978469 LinkDB All DBs Position Unknown AA seq 1054 aa AA seqDB search MAVAQDDVQRQQNGLFFAIPGPQTDCYVNLLRYQEVEDHVAFLITVPTALAIFFAIFILV CIESVFKKLLRLFSLVIWMCLVAMGYLFMCFGGTISPWDQVSFFLFIIFVVYTMLPFNMR DAIIASVLTSSSHTIVLSVCLSATPGTKEHLVWQILANVIIFICGNLAGAYHKHLMELAL QQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTN NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKI LGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVI GLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQH LVKTYFVINPKGERRSPHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMT TENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQ RISLLFYNKILEKEYRATALPAFKYYVTCACLIFFCIFVVQILVLPKTSILGISFGAAFL LLAFILFTCFAGQLLQCSKKASVSLLWLLKSSGIIADRPWPRVSLTVLTTAIILTMAVFN MFFLSDPEETIPPTANTSNTSLSASSNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRV NYELKMLIMMVALVGYNTILLHTHAHVLDDYSQVLFERPGIWKDLKTMGSVSLFIFFVTL LVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEE LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEK IKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKL RVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSFILQTLGYTC TCRGIINVKGKGELKTYFVNTEMSRSLSQSNLAS NT seq 3165 nt NT seq  +upstreamnt  +downstreamnt atggctgtagcccaggatgatgtccagaggcaacagaatggactgttctttgctatacct ggtccacagactgactgctatgtcaaccttttgaggtatcaggaagttgaagaccacgtg gcatttttaataacggtcccgacagccctggcgattttctttgcgatattcatcctagtc tgcatcgagtccgtgtttaagaagctgctccgccttttctccttggtgatatggatgtgt ctcgtggccatggggtacctgttcatgtgctttggaggcaccatctccccctgggaccag gtatcgttcttcctcttcattatcttcgtggtgtacaccatgctgcccttcaacatgaga gatgccatcattgccagcgtgctcacctcctcctcccacaccatcgtgctgagcgtctgc ctgtcggccacgccggggaccaaggagcacctggtctggcagatcctggctaatgtgatc attttcatctgtgggaacctggcgggagcctaccacaagcatctcatggagcttgccctg cagcagacctatcaggacacgtgcaactgtatcaagtctcggatcaaactggaatttgaa aagcgtcagcaggagcggcttctgctctccctgctgccggctcacatagccatggaaatg aaagccgagatcatccagaggctgcagggccccaaagccggccaaatggaaaacacaaac aactttcacaacctgtatgtcaagcgacacaccaacgtgagtatcctgtatgctgacatt gttggcttcacccggctggccagtgactgctctccaggagaattggtccacatgctgaac gagctctttggaaagtttgaccaaattgcaaaggagaatgaatgcatgagaataaaaatt ttgggagactgctactactgtgtgtccggactccctatatctctcccaaaccatgccaag aactgtgtgaaaatggggctggacatgtgtgaagccataaagaaagtgagggacgccact ggagtggatatcaacatgcgcgtgggcgtgcattctgggaacgtcctctgcggggtgatt ggtttgcagaagtggcagtatgacgtgtggtcacatgacgtgaccttggccaatcacatg gaagctggaggggtccctggacgtgttcacatttcttccgtcaccctggaacacttgaac ggcgcttataaagtggaggaaggagacggtgacataagagacccatatttaaaacagcac ctggtgaaaacctactttgtaatcaaccccaagggagaacgaaggagccctcacctcttc agacctcgccacaccctcgatggagccaagatgagggcatccgtgcgcatgacccggtac ctggagtcctggggagcggccaagccctttgcgcacctgcatcaccgagacagcatgacc acggagaatggcaaaatcagcaccacggatgtgccaatgggtcagcataattttcaaaat cgtaccttaagaaccaagtcccaaaagaaaagatttgaagaagaattaaatgaaaggatg attcaagcaattgatggaattaatgcacaaaagcagtggctcaagtctgaagacattcag agaatctcactcctgttctacaataaaatactagaaaaagaataccgagccaccgccctg ccagcgtttaagtactacgtgacctgtgcgtgtctcatattcttctgcatcttcgttgtg cagattctggtattaccgaaaacgtccattctcgggatctccttcggagctgcgtttctc ttgctcgccttcatcctcttcacctgctttgctggacagcttttgcaatgcagcaagaag gcctcggtctctctcctgtggctgttgaagtcgtccggcatcattgcggaccggccctgg ccgcgggtctccctcaccgtcctcaccacagccatcattctgaccatggccgtgttcaac atgtttttcctgagtgacccagaggaaacaattcctccaactgccaatacatccaacaca agtctttccgcctccagtaatcaggcagcgattctgcgggcacaaaatctgtttttcctc ccgtactttatctacagctgcattctgggactgatttcctgctcggtgttcctgagggtg aactacgagttgaagatgttgatcatgatggtggcattggtgggctacaacaccatcctt ctgcacactcacgcccacgtcctagacgactacagccaggtcttattcgagagaccaggc atttggaaagacctgaagaccatgggctcagtgtctctctttatattcttcgtcacactg cttgttctgggcagacagaatgaatattactgtaggttagacttcttatggaagaacaag ttcaaaaaagagcgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggag aacgtgctgcccgcgcacgtggcggagcatttcctggcccggagcctgaaaaacgaggag ttataccaccagtcctatgactgtgtctgcgtcatgtttgcctctattccggatttcaaa gaattctacacagaatcagatgtgaacaaggagggcttggaatgccttcggctcctgaat gagatcatcgccgactttgatgatttgctgtccaagccgaaattcagtggagttgaaaag atcaagaccattggcagcacatacatggcagcgacgggtctgagtgccgtgcccagccag gagcatgcccaggagcccgagaggcaatacatgcacattggcaccatggtggagtttgcc tttgccctggtggcaaaactggacgccatcaacaagcactccttcaacgacttcaagctg cgagtgggtattaaccatggacctgtgatagctggtgtgattggagctcagaagccacag tatgatatctggggcaacaccgtaaatgtggccagcaggatggacagcaccggcgtactg gacaaaatacaggtcaccgaggagacaagcttcatcctccagaccctgggatacacgtgc acgtgtcggggaataatcaacgtgaaaggcaagggggagctgaagacatactttgtaaac acagaaatgtcaaggtccctttcccagagcaacttggcatcctga

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