Escherichia coli clone D i2: i02_4565
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Entry
i02_4565 CDS
T02004
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
eld
Escherichia coli clone D i2
Pathway
eld00270
Cysteine and methionine metabolism
eld00450
Selenocompound metabolism
eld00670
One carbon pool by folate
eld01100
Metabolic pathways
eld01110
Biosynthesis of secondary metabolites
eld01230
Biosynthesis of amino acids
eld04980
Cobalamin transport and metabolism
eld04981
Folate transport and metabolism
Module
eld_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
eld00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
i02_4565 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
i02_4565 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
i02_4565 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
i02_4565 (metH)
04980 Cobalamin transport and metabolism
i02_4565 (metH)
Enzymes [BR:
eld01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
i02_4565 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AER87080
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All DBs
Position
4574390..4578088
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AA seq
1232 aa
AA seq
DB search
MSGASVSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDL
LVLSKPEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACA
DEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGA
DLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSL
RHAEALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQI
REWAEAGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSL
FVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVR
FLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRR
YGAAVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEH
NNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMG
IVNAGQLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWR
SWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFL
PQVVKSARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNY
EIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGA
TTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHG
RKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWS
LAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYR
DETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDALADA
FEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRP
APGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQI
QRDQVEDYARRKGMSVTEVERWLAPNLGYDAE
NT seq
3699 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgggagcaagtgtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgt
attctggtgctggacggcggtatgggcaccatgatccagagctatcgactgaacgaagcc
gattttcgtggtgaacgctttgccgactggccatgcgatctcaaaggcaacaacgacctg
ctggtgctcagcaaaccggaagtgatcgccgctatccacaacgcctactttgaagcgggc
gcggatatcatcgaaaccaacaccttcaactccacgactattgcgatggcggattaccaa
atggaatccctgtcggcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgct
gacgagtggactgcccgcacgccggagaaaccgcgctacgttgccggtgttctcggcccg
accaaccgcacggcgtctatttctccggacgtcaacgatccggcattccgcaacatcact
tttgaccagctggtggcggcttatcgagaatccaccaaagcgctggtggaaggtggcgcg
gacctgatcctgattgaaaccgttttcgacacccttaacgccaaagcggcggtctttgcg
gtgaaaacggagtttgaagcgctgggcgttgaactgccgattatgatctccggcaccatc
accgacgcctccgggcgcacgctctccgggcagaccactgaagcgttttacaactccctg
cgccacgccgaagcgctgacctttggcctgaactgtgcgctggggccagacgaactgcgc
cagtacgtacaggaactgtcgcgtattgcggaatgctacgtcaccgcccacccgaacgcc
gggctgcccaacgcctttggtgaatacgatctcgacgccgacacgatggcaaaacagata
cgtgaatgggcagaagcaggctttctcaatatcgtcggcggctgctgcggcaccacgcca
caacatattgcagcgatgagtcgtgcagtagaaggattagcgccgcgcaaactaccggaa
attcccgtagcctgccgcttgtccggcctggagccgctgaacattggcgaagatagcctg
tttgtgaacgtgggtgaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatc
aaagaagagaaatacagcgaggcgctggatgtggcgcgtcagcaggtggaaaacggtgcg
cagattatcgatatcaacatggatgaagggatgctcgatgccgaagcggcgatggtgcgt
tttctcaatctgattgccggtgaaccggatatcgctcgcgtgccgataatgatcgactcc
tcaaaatgggacgttattgaaaaaggtctgaagtgtatccagggcaaaggcattgttaac
tctatctcgatgaaagagggtgtcgacgcctttatccatcacgcgaaactgttgcgtcgc
tacggtgcggcagtcgtggtaatggcttttgacgaacagggccaggccgatacccgcgca
cggaaaatcgagatttgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccg
gctgaagatatcatcttcgacccgaacatcttcgcggtcgcaactggcattgaagagcac
aacaattacgcacaggactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcac
gcactgatttccggcggcgtttctaacgtgtcgttctcgtttcgtggcaacgatccggtg
cgcgaagccattcacgcggtgttcctctactacgctattcgcaatggcatggatatgggg
atcgtcaacgccgggcaactggcgatttacgacgacctgcctaccgaactacgcgacgcg
gtggaggatgtgatcctcaaccgtcgcgacgatggcaccgagcgtttactggagcttgcc
gagaaatatcgcggcagcaaaaccgacgacaccgctaacacccagcaggcggagtggcgc
tcgtgggaagtgaataaacgtctggaatactcgctggtcaaaggcattaccgagtttatc
gagcaggataccgaagaagcccgccagcaggctacgcgtccgattgaagtgattgaaggc
ccgttgatggacggcatgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctg
ccgcaggtggtgaaatcggcgcgcgtaatgaagcaggcggtggcgtatctcgagccgttc
attgaagccagcaaagagcagggtaaaaccaacggcaagatggtgatcgccacagtgaag
ggtgatgtccacgacatcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactac
gaaattgtcgatctcggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaa
gtgaatgctgatttgattggcctttcggggctgatcacgccgtcgctggacgagatggtt
aacgtggcgaaagagatggagcgtcagggcttcaccattccgctattgattggcggcgcg
accacctcaaaagcgcacacggcggtgaaaatcgagcagaactacagcggcccgacggtg
tatgtgcagaacgcatcgcgcaccgttggtgtggtggcggcgctgctttccgacactcag
cgcgatgatttcgttgctcgtacccgcaaggagtacgaaaccgtgcgtattcagcacgga
cgaaagaaaccacgcacaccaccggtcacgctggaagcggcgcgtgataacgacttcgct
tttgactggcaggcttacacgccgccggtggcgcaccgtctcggtgtgcaggaagtcgaa
gccagcatcgaaacgctgcgtaattacatcgactggacgccgttctttatgacctggtcg
ctggccgggaagtatccgcgcattctggaagatgaagtggtaggtgttgaggcgcagcgg
ctgtttaaagacgccaacgacatgctggataaattaagcgccgaaaaaatgctgaacccg
cgtggtgtggtgggcctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgt
gacgaaacgcgtacccatgtgattaatgtcagccaccatctacgccaacagaccgaaaaa
accggcttcgctaactactgtctcgctgacttcgttgcgccgaaggtttccggcaaagcg
gattacatcggcgcatttgccgtgactggcgggctggaagaggacgcactggctgatgcc
tttgaagcacagcatgatgattacaacaaaatcatggtgaaagcgcttgccgaccgtctg
gcggaagcctttgcggagtatctccatgagcgtgtgcgtaaagtctactggggctatgcg
ccgaacgagaacctcagcaacgaagagctgatccgcgaaaactaccagggcatccgtccg
gcaccgggctaccctgcctgcccggaacatacggaaaaagccacaatctgggagctgctg
gaagtggaaaaacataccggtatgaaactcacggaatccttcgccatgtggccgggtgca
tcggtttcgggttggtacttcagtcatccagacagcaagtattacgcggtggcgcaaatt
cagcgcgatcaggttgaagactatgcccgccgtaaaggaatgagcgttaccgaagtcgag
cgttggttggcaccgaatctggggtatgatgccgagtaa
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