Escherichia coli O55 H7 CB9615 (EPEC): G2583_4752
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Entry
G2583_4752 CDS
T01190
Symbol
metL
Name
(GenBank) Aspartokinase/homoserine dehydrogenase II
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
eok
Escherichia coli O55:H7 CB9615 (EPEC)
Pathway
eok00260
Glycine, serine and threonine metabolism
eok00261
Monobactam biosynthesis
eok00270
Cysteine and methionine metabolism
eok00300
Lysine biosynthesis
eok01100
Metabolic pathways
eok01110
Biosynthesis of secondary metabolites
eok01120
Microbial metabolism in diverse environments
eok01230
Biosynthesis of amino acids
Module
eok_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eok_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
eok_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
eok00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
G2583_4752 (metL)
00270 Cysteine and methionine metabolism
G2583_4752 (metL)
00300 Lysine biosynthesis
G2583_4752 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
G2583_4752 (metL)
Enzymes [BR:
eok01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
G2583_4752 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
G2583_4752 (metL)
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GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-ProteinID:
ADD59194
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Position
4824359..4826791
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AA seq
810 aa
AA seq
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MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADSLISAFVSDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPTSQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcagctgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagtactctcag
cctgacgatatgatggtggtttccgccgctggtagcaccactaaccagttgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcaggttcaacaaacgctgcgtcgc
tatcagtgcgatctgattagcggcctgctacccgccgaagaagccgatagcctcattagc
gcttttgtcagcgatcttgagcgcctggcggcgctgctcgacagcggtattaacgacgca
gtgtatgcggaagtggtgggccacggcgaagtgtggtcggcgcgcctgatgtctgcggtg
cttaatcaacaagggctgccagcggcctggcttgatgcccgcgagtttttacgcgctgaa
cgcgctgcgcaaccgcaggttgatgaagggctttcttacccgttgctgcaacagctactg
gtacaacatccgggtaaacgtctggtggtgaccgggtttatcagccgtaacaacgccggt
gaaacggtgctgctggggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgtgtaaccatctggagcgacgtcgccggggtatacagtgccgatccg
cgtaaagtgaaagatgcctgtctgctgccattgctgcgtctggatgaagccagcgaactg
gcgcgtctggcggctcccgttcttcacgcccgtactttacagccagtatccggtagcgaa
atcgacctgcagctgcgctgtagctacacgccggatcaaggctccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccacgatgatgtctgcttgatt
gagtttcaggtgcccaccagccaggatttcaaactggcgcataaagagatcgaccagatc
ctgaaacgtgctcaggtgcgcccactggcggttggcgtgcataacgatcgccagttgctg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggcgaactgcgcctgcgtcaggggctggcgctggtggcgatggtcggggcgggt
gtcacccgtaacccgctgcattgccaccgcttctggcagcaactgaaaggccagccggtc
gagtttacctggcagtccgatgacggcatcagcctggtggcagtactgcgcaccggcccg
accgaaagcctgattcagggcctgcatcagtccgtcttccgcgcagaaaaacgcatcggc
ctggtattgttcggcaaaggcaatatcggttcccgctggctggaactgttcgcccgcgag
cagagcacgctttcggcgcgtaccggctttgaatttgtgctggcaggcgtggtggacagc
cgccgcagtctgttgagttatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggtcgagcaggatgaagagtcgttgttcctgtggatgcgcgcccatccgtat
gatgatttagtggtgctggacgttaccgccagccagcagctggctgaccagtatcttgat
ttcgccagccacggtttccacgtcatcagtgccaacaaactggcgggagcaagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctatacaac
gccaccgtcggtgcgggcttgccgatcaaccataccgtgcgcgatctgatcgacagcggc
gatactattttgtcgatcagtgggatcttctccggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgagctggtggatcaggcgtggcagcagggcttaacc
gagcctgatccgcgtgacgacctctccggcaaagacgtaatgcgcaagctggtgattctg
gcgcgtgaagcgggttacaacattgaaccggaccaggtacgtgtggaatcgctggtgcct
gctcattgcgaaggcggcagcatcgaccatttctttgaaaatggcgatgaacttaacgag
cagatggtgcaacggctggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaacggcaaagcgcgtgtgggcgtggaggcggtgcgtgaagaccatccg
ctggcatcactgctaccgtgcgataacgtctttgccatcgaaagccgctggtatcgcgac
aacccgctggtgatccgtgggcctggcgcggggcgcgacgtcaccgccggggcgattcag
tcggatatcaaccggctggcacagttgttgtaa
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