KEGG   Equus przewalskii (Przewalski's horse): 103561550
Entry
103561550         CDS       T04644                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz01524  Platinum drug resistance
epz04012  ErbB signaling pathway
epz04014  Ras signaling pathway
epz04015  Rap1 signaling pathway
epz04024  cAMP signaling pathway
epz04062  Chemokine signaling pathway
epz04066  HIF-1 signaling pathway
epz04068  FoxO signaling pathway
epz04070  Phosphatidylinositol signaling system
epz04071  Sphingolipid signaling pathway
epz04072  Phospholipase D signaling pathway
epz04081  Hormone signaling
epz04140  Autophagy - animal
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04152  AMPK signaling pathway
epz04210  Apoptosis
epz04211  Longevity regulating pathway
epz04213  Longevity regulating pathway - multiple species
epz04218  Cellular senescence
epz04360  Axon guidance
epz04370  VEGF signaling pathway
epz04380  Osteoclast differentiation
epz04510  Focal adhesion
epz04550  Signaling pathways regulating pluripotency of stem cells
epz04611  Platelet activation
epz04613  Neutrophil extracellular trap formation
epz04620  Toll-like receptor signaling pathway
epz04625  C-type lectin receptor signaling pathway
epz04630  JAK-STAT signaling pathway
epz04650  Natural killer cell mediated cytotoxicity
epz04660  T cell receptor signaling pathway
epz04662  B cell receptor signaling pathway
epz04664  Fc epsilon RI signaling pathway
epz04666  Fc gamma R-mediated phagocytosis
epz04668  TNF signaling pathway
epz04670  Leukocyte transendothelial migration
epz04722  Neurotrophin signaling pathway
epz04725  Cholinergic synapse
epz04750  Inflammatory mediator regulation of TRP channels
epz04810  Regulation of actin cytoskeleton
epz04910  Insulin signaling pathway
epz04914  Progesterone-mediated oocyte maturation
epz04915  Estrogen signaling pathway
epz04917  Prolactin signaling pathway
epz04919  Thyroid hormone signaling pathway
epz04923  Regulation of lipolysis in adipocytes
epz04926  Relaxin signaling pathway
epz04929  GnRH secretion
epz04930  Type II diabetes mellitus
epz04931  Insulin resistance
epz04932  Non-alcoholic fatty liver disease
epz04933  AGE-RAGE signaling pathway in diabetic complications
epz04935  Growth hormone synthesis, secretion and action
epz04960  Aldosterone-regulated sodium reabsorption
epz04973  Carbohydrate digestion and absorption
epz05010  Alzheimer disease
epz05017  Spinocerebellar ataxia
epz05020  Prion disease
epz05100  Bacterial invasion of epithelial cells
epz05135  Yersinia infection
epz05142  Chagas disease
epz05146  Amoebiasis
epz05160  Hepatitis C
epz05161  Hepatitis B
epz05162  Measles
epz05163  Human cytomegalovirus infection
epz05164  Influenza A
epz05165  Human papillomavirus infection
epz05166  Human T-cell leukemia virus 1 infection
epz05167  Kaposi sarcoma-associated herpesvirus infection
epz05168  Herpes simplex virus 1 infection
epz05169  Epstein-Barr virus infection
epz05170  Human immunodeficiency virus 1 infection
epz05171  Coronavirus disease - COVID-19
epz05200  Pathways in cancer
epz05203  Viral carcinogenesis
epz05205  Proteoglycans in cancer
epz05206  MicroRNAs in cancer
epz05207  Chemical carcinogenesis - receptor activation
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05210  Colorectal cancer
epz05211  Renal cell carcinoma
epz05212  Pancreatic cancer
epz05213  Endometrial cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05218  Melanoma
epz05220  Chronic myeloid leukemia
epz05221  Acute myeloid leukemia
epz05222  Small cell lung cancer
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
epz05226  Gastric cancer
epz05230  Central carbon metabolism in cancer
epz05231  Choline metabolism in cancer
epz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
epz05415  Diabetic cardiomyopathy
epz05417  Lipid and atherosclerosis
epz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:epz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103561550 (PIK3R2)
   04014 Ras signaling pathway
    103561550 (PIK3R2)
   04015 Rap1 signaling pathway
    103561550 (PIK3R2)
   04370 VEGF signaling pathway
    103561550 (PIK3R2)
   04630 JAK-STAT signaling pathway
    103561550 (PIK3R2)
   04668 TNF signaling pathway
    103561550 (PIK3R2)
   04066 HIF-1 signaling pathway
    103561550 (PIK3R2)
   04068 FoxO signaling pathway
    103561550 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    103561550 (PIK3R2)
   04072 Phospholipase D signaling pathway
    103561550 (PIK3R2)
   04071 Sphingolipid signaling pathway
    103561550 (PIK3R2)
   04024 cAMP signaling pathway
    103561550 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    103561550 (PIK3R2)
   04152 AMPK signaling pathway
    103561550 (PIK3R2)
   04150 mTOR signaling pathway
    103561550 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103561550 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103561550 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    103561550 (PIK3R2)
   04218 Cellular senescence
    103561550 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103561550 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    103561550 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103561550 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103561550 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    103561550 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    103561550 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    103561550 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    103561550 (PIK3R2)
   04660 T cell receptor signaling pathway
    103561550 (PIK3R2)
   04662 B cell receptor signaling pathway
    103561550 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    103561550 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    103561550 (PIK3R2)
   04670 Leukocyte transendothelial migration
    103561550 (PIK3R2)
   04062 Chemokine signaling pathway
    103561550 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103561550 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    103561550 (PIK3R2)
   04929 GnRH secretion
    103561550 (PIK3R2)
   04915 Estrogen signaling pathway
    103561550 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    103561550 (PIK3R2)
   04917 Prolactin signaling pathway
    103561550 (PIK3R2)
   04926 Relaxin signaling pathway
    103561550 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    103561550 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    103561550 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103561550 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103561550 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    103561550 (PIK3R2)
   04722 Neurotrophin signaling pathway
    103561550 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103561550 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    103561550 (PIK3R2)
   04380 Osteoclast differentiation
    103561550 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    103561550 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    103561550 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103561550 (PIK3R2)
   05206 MicroRNAs in cancer
    103561550 (PIK3R2)
   05205 Proteoglycans in cancer
    103561550 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    103561550 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    103561550 (PIK3R2)
   05203 Viral carcinogenesis
    103561550 (PIK3R2)
   05230 Central carbon metabolism in cancer
    103561550 (PIK3R2)
   05231 Choline metabolism in cancer
    103561550 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103561550 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103561550 (PIK3R2)
   05212 Pancreatic cancer
    103561550 (PIK3R2)
   05225 Hepatocellular carcinoma
    103561550 (PIK3R2)
   05226 Gastric cancer
    103561550 (PIK3R2)
   05214 Glioma
    103561550 (PIK3R2)
   05221 Acute myeloid leukemia
    103561550 (PIK3R2)
   05220 Chronic myeloid leukemia
    103561550 (PIK3R2)
   05218 Melanoma
    103561550 (PIK3R2)
   05211 Renal cell carcinoma
    103561550 (PIK3R2)
   05215 Prostate cancer
    103561550 (PIK3R2)
   05213 Endometrial cancer
    103561550 (PIK3R2)
   05224 Breast cancer
    103561550 (PIK3R2)
   05222 Small cell lung cancer
    103561550 (PIK3R2)
   05223 Non-small cell lung cancer
    103561550 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103561550 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    103561550 (PIK3R2)
   05161 Hepatitis B
    103561550 (PIK3R2)
   05160 Hepatitis C
    103561550 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    103561550 (PIK3R2)
   05164 Influenza A
    103561550 (PIK3R2)
   05162 Measles
    103561550 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    103561550 (PIK3R2)
   05163 Human cytomegalovirus infection
    103561550 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103561550 (PIK3R2)
   05169 Epstein-Barr virus infection
    103561550 (PIK3R2)
   05165 Human papillomavirus infection
    103561550 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103561550 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    103561550 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103561550 (PIK3R2)
   05142 Chagas disease
    103561550 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103561550 (PIK3R2)
   05017 Spinocerebellar ataxia
    103561550 (PIK3R2)
   05020 Prion disease
    103561550 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103561550 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    103561550 (PIK3R2)
   05415 Diabetic cardiomyopathy
    103561550 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103561550 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    103561550 (PIK3R2)
   04931 Insulin resistance
    103561550 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103561550 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103561550 (PIK3R2)
   01524 Platinum drug resistance
    103561550 (PIK3R2)
   01522 Endocrine resistance
    103561550 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:epz04131]
    103561550 (PIK3R2)
Membrane trafficking [BR:epz04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103561550 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e ATG11 SH3_1 SH3_9
Other DBs
NCBI-GeneID: 103561550
NCBI-ProteinID: XP_070442701
LinkDB
Position
20:2855992..2867668
AA seq 723 aa
MAGAEGFQYRALYRFRRERPEDLELLPGDVLVVSRAALQALGVAEGSERCPQSVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDAAPPILVKLVEAIEQTGLDGDSLYRPEPPAPRTDWSLSDVEQWDAAALSDGVKGFLLA
LPAPLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRLARRAPAPG
PAVRALGAAFGPLLLRAPPPSPPPGGAPDGTEPGPDFPGLLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPTGVANGGSLPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFGSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLRVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEEDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLRELVLHYQHTSLLQHNDALAVTLAHPVRAPAPA
PAR
NT seq 2172 nt   +upstreamnt  +downstreamnt
atggctggtgctgaaggcttccaataccgggcgctttaccggttccgccgggagcggccc
gaggacctagagctgctgccgggcgacgtgctggtggtgagccgggcagccttgcaggcg
ctgggcgtggcggagggcagtgagcgctgcccgcagagtgtgggctggatgcctggcttc
aacgagcgcacgcggcagcgtggcgacttccccggcacctacgttgagttcctggggccc
gtggccctggcccggcctggccctcgcccccgaggcccccgcccactgcctgccaggccc
cgagatggacccccggagccaggcctcacactccccgacctgcctgagcagttctcccca
cctgatgcggctcctcccatcctggtgaagctcgtggaagccattgagcagacagggcta
gacggtgactccctctacaggccggagccgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgcggccgccctgtcagacggcgtcaagggtttcctgctggcg
ctgcccgcgcccctcgtgacgcccgaggcggcggccgaggcgcaccgggccctgagggag
gccgcggggcccgtgggaccggcgctggagccgccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcctggcgcggcgcgcccccgccccgggc
cccgccgtgcgcgcgctgggcgcggccttcgggccgctgctgctgcgcgcgccgccgccc
tcgccgccgccagggggcgcgcccgacggcactgagcccggcccagacttcccagggctg
ctggtggagaagttgcttcaggagcatctggaggagcaggaggtggcacccccagcacta
ccacctaaaccccccaaggcaaagccggcccccacaggtgtggccaatggggggagcctg
ccctccctgcaggatgctgagtggtactggggcgacatctccagggaggaggtgaatgag
aaactccgggacacgcctgatggcacctttctggtccgagatgcctccagcaagatccag
ggggagtacacgctgaccctcaggaaaggcgggaacaacaagctgattaaagttttccac
cgtgacgggcactatggcttctcggagccgctgaccttcggctccgtggtggatctcatc
acccactaccgccatgagtcgttggcccagtacaacgccaaactggacacgcggctcctc
taccccgtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggtgctcagctcagggtctaccaccagcagtaccaggacaagagccgcgagtacgaccag
ctgtacgaggagtacacgcgcacctcccaggaactgcagatgaagcgcacagcaattgaa
gctttcaatgagacgattaagatctttgaagagcagggccagacacaagagaagtgcagc
aaggaatatctggagcgcttccggcgtgagggcaatgagaaggagatgcaaaggatcctg
ctgaactcagagcggctcaagtctcgcatcgctgagatccacgagagccgcacaaagctg
gagcaggagctgcgtgcacaggcctcagacaaccgggagattgacaagcgcatgaacagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaacgagactgag
gaccaatatgcgctgatggaggatgaggaggacctcccccaccatgaggagcgcacgtgg
tatgtgggcaagatcaaccgcacgcaggccgaagaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctcggtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacggccacgggcttcggcttcgcggagccc
tacaacctgtacggctcgctgcgggagctggtgctgcactaccagcacacgtcgctgctg
cagcacaacgacgcgctcgccgtcacgctcgcccacccggtgcgcgcgcccgcgcccgcg
cccgcgcgctga

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