KEGG   PATHWAY: esp04136
Entry
esp04136                    Pathway                                
Name
Autophagy - other - Etheostoma spectabile (orangethroat darter)
Description
Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
Class
Cellular Processes; Transport and catabolism
Pathway map
esp04136  Autophagy - other
esp04136

Other DBs
GO: 0006914
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116670044  atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
116670140  atg4d; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
116670203  [KO:K17907]
116670731  becn1; beclin-1 [KO:K08334]
116671352  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
116671486  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
116671892  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
116673708  atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
116673755  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
116679466  pik3r4; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
116679841  [KO:K17907]
116685720  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
116686377  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
116687423  atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
116689965  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116691314  [KO:K08341]
116691436  atg5; autophagy protein 5 [KO:K08339]
116691548  atg12; ubiquitin-like protein ATG12 [KO:K08336]
116692591  mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
116693480  [KO:K08341]
116693481  [KO:K08341]
116695060  atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
116695872  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
116696970  atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
116697222  [KO:K04382] [EC:3.1.3.16]
116699453  [KO:K17907]
116699664  atg10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
116700179  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116700515  atg101; autophagy-related protein 101 [KO:K19730]
116702383  [KO:K08342] [EC:3.4.22.-]
116702523  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
116702587  [KO:K17908]
116703502  wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
116706994  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  Title
Autophagy in protists.
  Journal
Autophagy 7:127-58 (2011)
DOI:10.4161/auto.7.2.13310
Reference
  Authors
Avin-Wittenberg T, Honig A, Galili G
  Title
Variations on a theme: plant autophagy in comparison to yeast and mammals.
  Journal
Protoplasma 249:285-99 (2012)
DOI:10.1007/s00709-011-0296-z
Reference
  Authors
Liu Y, Bassham DC
  Title
Autophagy: pathways for self-eating in plant cells.
  Journal
Annu Rev Plant Biol 63:215-37 (2012)
DOI:10.1146/annurev-arplant-042811-105441
Reference
  Authors
Yoshimoto K
  Title
Beginning to understand autophagy, an intracellular self-degradation system in plants.
  Journal
Plant Cell Physiol 53:1355-65 (2012)
DOI:10.1093/pcp/pcs099
Reference
  Authors
Li F, Chung T, Vierstra RD
  Title
AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  Journal
Plant Cell 26:788-807 (2014)
DOI:10.1105/tpc.113.120014
Reference
  Authors
Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  Title
Autophagy in Plants--What's New on the Menu?
  Journal
Trends Plant Sci 21:134-44 (2016)
DOI:10.1016/j.tplants.2015.10.008
Reference
  Authors
Yang X, Bassham DC
  Title
New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  Journal
Int Rev Cell Mol Biol 320:1-40 (2015)
DOI:10.1016/bs.ircmb.2015.07.005
KO pathway
ko04136   

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