KEGG   Escherichia coli O157 H7 TW14359 (EHEC): ECSP_0529
Entry
ECSP_0529         CDS       T00949                                 
Symbol
acrB
Name
(GenBank) multidrug efflux system protein
  KO
K18138  multidrug efflux pump
Organism
etw  Escherichia coli O157:H7 TW14359 (EHEC)
Pathway
etw01501  beta-Lactam resistance
etw01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
KEGG Orthology (KO) [BR:etw00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    ECSP_0529 (acrB)
   01503 Cationic antimicrobial peptide (CAMP) resistance
    ECSP_0529 (acrB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:etw02000]
    ECSP_0529 (acrB)
   01504 Antimicrobial resistance genes [BR:etw01504]
    ECSP_0529 (acrB)
Transporters [BR:etw02000]
 Other transporters
  Electrochemical potential-driven transporters [TC:2]
   ECSP_0529 (acrB)
Antimicrobial resistance genes [BR:etw01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]
    ECSP_0529 (acrB)
SSDB
Motif
Pfam: ACR_tran SecD_SecF_C
Other DBs
NCBI-ProteinID: ACT70406
LinkDB
Position
complement(552498..555647)
AA seq 1049 aa
MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT
VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ
EVQQQGVSIEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS
QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL
TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL
DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ
NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM
AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL
SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR
YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT
KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD
AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG
LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR
MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA
MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFS
VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL
IEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIF
FVPVFFVVVRRRFSRKNEDIEHNHTVDHH
NT seq 3150 nt   +upstreamnt  +downstreamnt
atgcctaatttctttatcgatcgcccgatttttgcgtgggtgatcgccattatcatcatg
ttggcaggggggctggcgatcctcaaactgccggtggcgcaatatcctacgattgcaccg
ccggcagtaacgatctccgcctcctaccccggcgctgatgcgaaaacagtgcaggacacg
gtgacacaggttatcgaacagaatatgaacggtatcgataacctgatgtacatgtcctct
aacagtgactccacgggtaccgtacagatcaccctgacctttgagtctggtactgatgcg
gatatcgcgcaggttcaggtgcagaacaaactgcagctggcgatgccgttgctgccgcaa
gaagttcagcagcaaggggtgagcattgagaaatcatccagcagcttcctgatggttgtc
ggcgttatcaacaccgatggcaccatgacgcaggaggatatctccgactacgtggcggcg
aatatgaaagatgccatcagccgtacgtctggcgtgggtgacgttcagttgttcggttca
cagtacgcgatgcgtatctggatgaacccgaatgaactgaacaaattccagctaacgccg
gttgatgttattaccgccatcaaagcgcagaacgcccaggttgcggcgggccagctcggt
ggtacaccgccggtgaaaggccaacagcttaacgcctctattattgctcagacgcgtctg
acctctactgaagagttcggcaaaatcctgctgaaagtgaatcaggatggttcccgcgta
ctgctgcgtgatgtggcgaagattgagctgggtggtgagaactacgacatcatcgcagag
tttaacggccaaccggcttccggtctggggatcaagctggcgaccggtgcaaacgcgctg
gataccgctgcggcaatccgtgctgaactggcgaagatggaaccgttcttcccgtcgggt
ctgaaaattgtttacccgtacgacaccacgccgttcgtgaaaatctctattcacgaagtg
gttaaaacgctggtcgaagcgatcatcctcgtgttcctggttatgtatctgttcctgcag
aacttccgcgcgacgttgattccgaccattgccgtaccggtggtattgctcgggaccttt
gccgtccttgccgcctttggcttctcgataaacacgctaacaatgttcgggatggtgctc
gccatcggcctgttggtggatgacgctatcgttgtggtagaaaacgttgagcgtgtgatg
gcggaagaaggtttgccgccaaaagaagccacccgtaagtcgatggggcagattcagggc
gctctggtcggtatcgcgatggtactgtcggcggtattcgtaccgatggccttctttggc
ggttctactggggcaatttatcgtcagttctctattaccattgtttcagcaatggcgctg
tcggtactggtggcgttgatcctgactccagctctttgtgccaccatgctgaaaccgatt
gccaaaggcgatcacggggaaggtaaaaaaggcttcttcggctggtttaaccgcatgttc
gagaagagcacgcaccactacaccgacagcgtaggcggtattctgcgcagtacggggcgt
tatctggtgctgtatctgatcatcgtggtcggcatggcctatctgtttgtgcgtctgcca
agctccttcttgccagatgaggaccagggcgtatttatgaccatggttcagctgccagca
ggtgcaacgcaggaacgtacgcagaaagtgctcaatgaggtaacgcattactatctgacc
aaagaaaagaacaacgttgagtcggtgttcgccgttaacggcttcggctttgcgggacgt
ggtcagaataccggtattgcgttcgtttccttgaaggactgggccgatcgtccgggtgaa
gaaaacaaagttgaagcgattaccatgcgtgcaacacgcgctttctcgcaaatcaaagat
gcgatggttttcgcctttaacctgcccgcaatcgtggaactgggtaccgcaaccggcttt
gactttgagctgattgaccaggctggccttggtcacgaaaaactgactcaggcgcgtaac
cagttgcttgcagaagcagcgaagcaccctgatatgttgaccagcgtacgtccaaacggt
ctggaagataccccgcagtttaagattgatatcgaccaggaaaaagcgcaggcgctgggt
gtttctatcaacgacattaacaccactctgggcgctgcatggggcggcagctatgtgaac
gactttatcgaccgcggtcgtgtgaagaaagtttacgtcatgtcagaagcgaaataccgt
atgctgccggatgatatcggcgactggtatgttcgtgctgctgatggtcagatggtgcca
ttctcggcgttctcctcttctcgttgggagtacggttcgccgcgtctggaacgttacaac
ggcctgccatccatggaaatcttaggccaggcggcaccgggtaaaagtaccggtgaagca
atggagctgatggaacaactggcgagcaaactgcctaccggtgttggctatgactggacg
gggatgtcctatcaggaacgtctctccggcaaccaggcaccttcactgtacgcgatttcg
ttgattgtcgtgttcctgtgtctggcggcgctgtacgagagctggtcgattccgttctcc
gttatgctggtcgttccgctgggggttatcggtgcgttgctggctgccaccttccgtggc
ctgaccaatgacgtttacttccaggtaggcctgctcacaaccattgggttgtcggcgaag
aacgcgatacttatcgtcgaattcgccaaagacttgatggataaagaaggtaaaggtctg
attgaagcgacgcttgatgcggtgcggatgcgtttacgtccgatcctgatgacctcgctg
gcgtttatcctcggcgttatgccgctggttatcagtactggtgctggttccggcgcgcag
aacgcagtaggtaccggtgtaatgggcgggatggtgaccgcaacggtactggcaatcttc
ttcgttccggtattctttgtggtggttcgccgccgctttagccgcaagaatgaagatatc
gagcacaaccatactgtcgatcatcattga

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