Felis catus (domestic cat): 100127108 Help Entry 100127108         CDS       T02385                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism fca  Felis catus (domestic cat) Pathway fca04010   MAPK signaling pathway fca04014   Ras signaling pathway fca04015   Rap1 signaling pathway fca04022   cGMP-PKG signaling pathway fca04066   HIF-1 signaling pathway fca04068   FoxO signaling pathway fca04072   Phospholipase D signaling pathway fca04081   Hormone signaling fca04150   mTOR signaling pathway fca04151   PI3K-Akt signaling pathway fca04152   AMPK signaling pathway fca04211   Longevity regulating pathway fca04213   Longevity regulating pathway - multiple species fca04520   Adherens junction fca04910   Insulin signaling pathway fca04913   Ovarian steroidogenesis fca04923   Regulation of lipolysis in adipocytes fca04930   Type II diabetes mellitus fca04931   Insulin resistance fca04932   Non-alcoholic fatty liver disease fca04960   Aldosterone-regulated sodium reabsorption fca05010   Alzheimer disease fca05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100127108 (INSR)    04014 Ras signaling pathway     100127108 (INSR)    04015 Rap1 signaling pathway     100127108 (INSR)    04066 HIF-1 signaling pathway     100127108 (INSR)    04068 FoxO signaling pathway     100127108 (INSR)    04072 Phospholipase D signaling pathway     100127108 (INSR)    04022 cGMP-PKG signaling pathway     100127108 (INSR)    04151 PI3K-Akt signaling pathway     100127108 (INSR)    04152 AMPK signaling pathway     100127108 (INSR)    04150 mTOR signaling pathway     100127108 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     100127108 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100127108 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100127108 (INSR)    04923 Regulation of lipolysis in adipocytes     100127108 (INSR)    04913 Ovarian steroidogenesis     100127108 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100127108 (INSR)   09149 Aging    04211 Longevity regulating pathway     100127108 (INSR)    04213 Longevity regulating pathway - multiple species     100127108 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100127108 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100127108 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100127108 (INSR)    04932 Non-alcoholic fatty liver disease     100127108 (INSR)    04931 Insulin resistance     100127108 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:fca01001]     100127108 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:fca04090]     100127108 (INSR) Enzymes [BR:fca01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100127108 (INSR) Protein kinases [BR:fca01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100127108 (INSR) CD molecules [BR:fca04090]  Proteins   100127108 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 Motif Other DBs NCBI-GeneID:  100127108 NCBI-ProteinID:  XP_023100560 LinkDB All DBs Position A2:6387620..6531220 Genome browser AA seq 1381 aa AA seqDB search MGAGAGRGAATAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VVFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHGHCQKVCPTVCKSHGCTADGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHNKCKNSRRQG CHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKRNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKSFSSPGAEDSRPSRKRRALADAGNVTAAVPTVPGF PNTSSSVPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE KITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF TCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC PERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF EDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDHIPYTHMNGGKKNGRILTLPRSNP S NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggccaccgcgccgctgctggtggcggtggccgcg ctgctgctgggcgccgcgggccacctgtaccccggagaggtctgccctggcatggatatc cggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaaggtcatttg cagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagtttccccaaa ctcgtcatgatcactgattacctgctgctcttccgggtgtacgggctggagagcctgaag gacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcgctg gtcgtcttcgagatggtgcacttgaaggagcttggcctctacagcttgatgaacattacc cggggctccgtccgcatcgagaagaataatgagctgtgctacctggccaccatcgactgg tcgcgcatcctggattcggtggaggataattacattgtgttgaacaaagacgacaacgag gagtgtggggacatttgtccaggcactgcaaagggcaagaccaactgccctgccactgtc atcaacgggcagtttgtggagcgttgttggacacacggccattgccagaaagtttgtccg accgtctgcaagtcgcacggctgcacggccgacggcctctgctgccacagcgagtgtttg ggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagactggcgctgc gtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccggagacagggt tgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcggggtacacg atgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaaggtctgccac atcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggctgc accgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctggcagctgag ctggaggccaacctcggactcattgaagaaatttctgggtatctgaagatccgaagatcc tatgctcttgtgtcactttcctttttccggaagttacggctgattcggggagagaccttg gaaatcgggaactactctttctatgccttggacaaccagaacctgaggcagctatgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcggagattcacaagatggaggaggtttcaggaaccaaggggcgccaggag cggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaactactt aaattttcttacattcggacgtcttacgacaagatcttgctgaaatgggaaccgtactgg ccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggccccttaccag aatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtggtggac attgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccagggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttttct gatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagaccgatgccacc aacccttccgtccccctggatcctatctcggtttcgaattcctcctctcagatcattctg aagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtgttctgggag aggcaggcggaggacagcgagctgtatgagttggattattgcctcaaagggttgaagctg ccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcgcaatcagagt gagtacgaggagtccgctggcgaatgctgctcgtgtcccaaaaccgactctcagatcctg aaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcacaatgtggtt ttcgtgcccagaaaatccttttcaagccctggtgctgaggacagtaggccgtcgcggaag cgcagggccctcgccgacgctgggaacgtgacggccgccgtgcccacggtgcctggtttc cccaacacttccagcagcgtgcccacgagcccggaagagcacaagcccttcgagaaggtg gtgaacaaagagtcgctggtcatctccggcctgcgtcacttcaccggctaccgcatcgag ctgcaggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcctacgtcagc gccaggaccatgcccgaagccaaggcagacgacattgttggccctgtgacccatgaaatc ttcgagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaatggattgatc gtgctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctctgtgtctcc cgtagacactttgctctggagcggggctgcaggctgcgagggctgccgccggggaattac agtgtgcgagttcgggccacctccctggcgggcaacggctcctggacagaagccacttat ttctatgtgacagactatttagatgtcccatcgaacattgcaaaaattatcatcgggcct ctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattcctgagaaag aggcagccggatgggccgctggggccgctgtatgcttcttcaaaccctgagtacctcagt gccagtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtgcctcgggag aagatcactctcctgcgcgagctggggcagggctccttcggcatggtatacgagggcaat gccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgag tccgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatgaagggcttc acctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccgacgctggtg gtgatggagctgatggttcacggagacctgaagagctacctccgctccctgcggccggag gctgagaataaccctggccgccctccccctactctgcaagagatgattcagatggcggcg gagatcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgggatctcgca gctcgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttcggaatgacc agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcgg tggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgacatgtggtcc tttggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaaggcctgtct aatgaacaggtgttgaaatttgtcatggacggaggatatttggaccaacctgacaactgt ccggagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaagatgcggccc accttcctggagatcgttgacctgctcaaggacgacctgcaccccagctttccagaagtt tccttcttccacagcgaggagaacaaggcgcctgagagtgaggagttggaaatggagttt gaggacatggagagtgtccccctggatcgggcctcacactcacagagggaagaggccggg ggccgggatggagtatcctcgctgggcctcaagcggaactacgaggaccacatcccctac acccacatgaacgggggcaagaaaaacggacggattctgaccctgccgaggtcgaatcct tcctaa

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