Felis catus (domestic cat): 101087257 Help Entry 101087257         CDS       T02385                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism fca  Felis catus (domestic cat) Pathway fca04022   cGMP-PKG signaling pathway fca04068   FoxO signaling pathway fca04081   Hormone signaling fca04140   Autophagy - animal fca04150   mTOR signaling pathway fca04151   PI3K-Akt signaling pathway fca04152   AMPK signaling pathway fca04211   Longevity regulating pathway fca04213   Longevity regulating pathway - multiple species fca04722   Neurotrophin signaling pathway fca04910   Insulin signaling pathway fca04920   Adipocytokine signaling pathway fca04923   Regulation of lipolysis in adipocytes fca04930   Type II diabetes mellitus fca04931   Insulin resistance fca04932   Non-alcoholic fatty liver disease fca04935   Growth hormone synthesis, secretion and action fca04960   Aldosterone-regulated sodium reabsorption fca05010   Alzheimer disease fca05206   MicroRNAs in cancer fca05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     101087257 (IRS1)    04022 cGMP-PKG signaling pathway     101087257 (IRS1)    04151 PI3K-Akt signaling pathway     101087257 (IRS1)    04152 AMPK signaling pathway     101087257 (IRS1)    04150 mTOR signaling pathway     101087257 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     101087257 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101087257 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101087257 (IRS1)    04923 Regulation of lipolysis in adipocytes     101087257 (IRS1)    04920 Adipocytokine signaling pathway     101087257 (IRS1)    04935 Growth hormone synthesis, secretion and action     101087257 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     101087257 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     101087257 (IRS1)   09149 Aging    04211 Longevity regulating pathway     101087257 (IRS1)    04213 Longevity regulating pathway - multiple species     101087257 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     101087257 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     101087257 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     101087257 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101087257 (IRS1)    04932 Non-alcoholic fatty liver disease     101087257 (IRS1)    04931 Insulin resistance     101087257 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  101087257 NCBI-ProteinID:  XP_003991268 UniProt:  M3WUW8 LinkDB All DBs Position C1:complement(209606799..209669200) Genome browser AA seq 1234 aa AA seqDB search MASPPETEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKSH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRYVAGAGLGTSPALAGDEGASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEVHRGHHRPDTSS LHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMM SPSGSCSPDIGGGPSSSGSGAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESGGGKLLS CTGDYINMSPVGDSNTSSPSDCYYGQEDPQHKPVLSYYSLPRSFKHTQRPGELEESARHQ HLRLSSSSGRLLYATTAEDSSSSTSSDSLGGGYCGVRPDSGLPHIHHQVLQPHLPRKVDT AAQTNSRLARPTRLSLGDPKASTLPRVREQQPQPPLLHPPEPKSPGEYVNIEFGGDQPGY LSGPVASRGSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQEGAGDQPGRVGPT PPGAASVCRPTRAVPSSRGHYMTMQMGCPGQSYVDTSPVAPISYADMRTGLVAEEASLPG ATAAAPSSSSAASASPTAPQKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVI RADPQGCRRRHSSETFSSTPSATRAGNTVPFGGGAAGGGSGGGNGSAEEVKRHSSASFEN VWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQPPPPPPPH QPLGSSEGSSTRRSSEDLSAYASISFQKQPEDLQ NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgaaggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcggacagcgag gcggagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagagccac cacgacggggccgcggcccccggggcaggaggcggcgggggcagctgcagtggcagctcg ggcctcggcgaggctggggaggacttgagctacggggatgtgcccccaggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgtctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccactccgagaacttc ttcttcatcgaagtgggccgttccgcggtgacgggacctggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgacgagttccgtcctcgaagtaagagccagtcctcttccaactgctccaaccccatc agcgtcccgctgcgcaggcaccacctcaacaacccgccacccagccaggtggggctgacc cgccgctctcgcaccgagagcatcaccgccacctctccggccagcatggtgggcgggaag cagggctccttccgcgtgcgcgcgtccagcgacggcgagggcaccatgtcccgcccggcc tcggtggacggcagccccgtgagtcctagcaccaacaggacgcacgcgcaccggcatcgc ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcgtcc cgctgctcgccttctgccaccagcccggtcagtctgtcgtccagcagcaccagtggccac ggctccacctcggactgcctcttcccccggcgctctagtgcttctgtgtccggttccccc agcgatggcggtttcatctcctcggacgagtacggctccagtccttgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacaccccaccggcccgcggggaggag gagctgagcaactacatctgcatgggaggcaaaggatcctccaccctcaccgcccccaat ggtcactacattttgcctcggggtggcaatggtcaccgctacgtcgccggggccggcctg ggcaccagcccagccctggccggggatgaaggagctagtgcagccgatctggataatcgg ttccgaaagcggactcactcggccggcacgtcccctaccatttcccaccagaagacccca tcgcagtcctcggtggcttccattgaggagtacacggagatgatgcctgcctacccgcca ggaggtggcagcggaggccgcctgcccggctaccggcactccgccttcgtgcccacccac tcctaccccgaggagggtctggaggtgcaccggggccaccaccgcccagacacctcctct ctccacactgatgatggctacatgcccatgtccccaggagtggccccagtgcccagcagc cgcaagggcagcggggactacatgcccatgagccccaagagcgtgtctgcgccacagcag atcatcaaccccatcaggcgccatccccagagggtggatcccaatggctacatgatgatg tcccctagcggcagctgctctcctgacatcggaggtgggcccagcagcagcggcagcggc gccgccccctctgggagcagctacgggaagctgtggaccaacggggtcgggggccaccac cctcacgctctgccacatcccaaactccccgtagagagtggtggcggcaagctcttgtct tgtactggtgactacataaatatgtcgccggtgggggactccaataccagcagcccctcc gactgctactatggccaggaggacccccagcacaagccagtcctctcctactactcgttg ccaaggtcctttaagcacacccagcgccccggggagctggaggagagtgcccggcaccag cacctccgcctttcctccagctctggtcgccttctctatgccaccaccgcagaagattcc tcctcctctaccagcagcgacagcctgggcggcgggtactgtggggtcaggcccgattct ggcctcccgcacatccaccatcaggtcctgcagccccatctgcctcgaaaggtggacaca gctgcccagaccaacagccgcctggctcggcccacgaggctgtccctgggggatcccaag gccagcaccttacctcgggtccgagagcagcagccacagcccccgctgctgcaccctccg gagcccaagagcccaggggaatatgtgaatattgagtttgggggggatcagccgggctac ttatctggtcccgtggcttcccgcggctcgccttctgtcaggtgcccatcccagctccag ccagcccccagggaggaagagactggcactgaagagtacatgaacatggacctggggcca ggcaggagggccacctggcaggagggtgccggggaccagccaggcagagtgggccccaca cctcctggggcggccagcgtgtgcaggcccacccgggccgtgcccagcagccgcggtcac tacatgaccatgcagatgggctgtcctggtcagagctatgtggacacctcaccagttgcc cccatcagctatgctgacatgcggacaggcctcgttgcggaggaggcgagccttccgggg gccacggccgccgctccctcctcatcctcggcggcctcggcttcccccactgcacctcaa aaagcaggggagctggtggcccgctcttccctgctggggggcccgcagggacccggaggc atgagcgccttcaccagggtgaacctcagccccaaccggaaccagagtgccaaagtgatc cgtgcggacccgcaagggtgccggaggcggcacagctctgagaccttctcctcgacaccc agtgccacccgggcgggcaacacggtgcccttcggagggggcgctgcaggagggggcagc ggtggtggcaacggcagcgccgaggaggtgaaacgccacagttctgcttccttcgagaac gtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaagtgtgcggg gccgccgggggtttggagaacgggcttaactacatagacctggatttggtcaaggacttc aaacagcgccctcaggagcgcccccctcaaccacagccgccccctcccccgccccctcat cagcctctgggcagcagcgagggcagctccacccgccgctccagcgaggatttaagcgcc tatgccagcatcagtttccagaagcagccagaggacctccagtag

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