KEGG   Felis catus (domestic cat): 101093586
Entry
101093586         CDS       T02385                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
fca  Felis catus (domestic cat)
Pathway
fca01521  EGFR tyrosine kinase inhibitor resistance
fca01522  Endocrine resistance
fca01524  Platinum drug resistance
fca04012  ErbB signaling pathway
fca04014  Ras signaling pathway
fca04015  Rap1 signaling pathway
fca04024  cAMP signaling pathway
fca04062  Chemokine signaling pathway
fca04066  HIF-1 signaling pathway
fca04068  FoxO signaling pathway
fca04070  Phosphatidylinositol signaling system
fca04071  Sphingolipid signaling pathway
fca04072  Phospholipase D signaling pathway
fca04081  Hormone signaling
fca04140  Autophagy - animal
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04152  AMPK signaling pathway
fca04210  Apoptosis
fca04211  Longevity regulating pathway
fca04213  Longevity regulating pathway - multiple species
fca04218  Cellular senescence
fca04360  Axon guidance
fca04370  VEGF signaling pathway
fca04380  Osteoclast differentiation
fca04510  Focal adhesion
fca04550  Signaling pathways regulating pluripotency of stem cells
fca04611  Platelet activation
fca04613  Neutrophil extracellular trap formation
fca04620  Toll-like receptor signaling pathway
fca04625  C-type lectin receptor signaling pathway
fca04630  JAK-STAT signaling pathway
fca04650  Natural killer cell mediated cytotoxicity
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04664  Fc epsilon RI signaling pathway
fca04666  Fc gamma R-mediated phagocytosis
fca04668  TNF signaling pathway
fca04670  Leukocyte transendothelial migration
fca04722  Neurotrophin signaling pathway
fca04725  Cholinergic synapse
fca04750  Inflammatory mediator regulation of TRP channels
fca04810  Regulation of actin cytoskeleton
fca04910  Insulin signaling pathway
fca04914  Progesterone-mediated oocyte maturation
fca04915  Estrogen signaling pathway
fca04917  Prolactin signaling pathway
fca04919  Thyroid hormone signaling pathway
fca04923  Regulation of lipolysis in adipocytes
fca04926  Relaxin signaling pathway
fca04929  GnRH secretion
fca04930  Type II diabetes mellitus
fca04931  Insulin resistance
fca04932  Non-alcoholic fatty liver disease
fca04933  AGE-RAGE signaling pathway in diabetic complications
fca04935  Growth hormone synthesis, secretion and action
fca04960  Aldosterone-regulated sodium reabsorption
fca04973  Carbohydrate digestion and absorption
fca05010  Alzheimer disease
fca05017  Spinocerebellar ataxia
fca05020  Prion disease
fca05100  Bacterial invasion of epithelial cells
fca05135  Yersinia infection
fca05142  Chagas disease
fca05146  Amoebiasis
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05162  Measles
fca05163  Human cytomegalovirus infection
fca05164  Influenza A
fca05165  Human papillomavirus infection
fca05166  Human T-cell leukemia virus 1 infection
fca05167  Kaposi sarcoma-associated herpesvirus infection
fca05168  Herpes simplex virus 1 infection
fca05169  Epstein-Barr virus infection
fca05170  Human immunodeficiency virus 1 infection
fca05171  Coronavirus disease - COVID-19
fca05200  Pathways in cancer
fca05203  Viral carcinogenesis
fca05205  Proteoglycans in cancer
fca05206  MicroRNAs in cancer
fca05207  Chemical carcinogenesis - receptor activation
fca05208  Chemical carcinogenesis - reactive oxygen species
fca05210  Colorectal cancer
fca05211  Renal cell carcinoma
fca05212  Pancreatic cancer
fca05213  Endometrial cancer
fca05214  Glioma
fca05215  Prostate cancer
fca05218  Melanoma
fca05220  Chronic myeloid leukemia
fca05221  Acute myeloid leukemia
fca05222  Small cell lung cancer
fca05223  Non-small cell lung cancer
fca05224  Breast cancer
fca05225  Hepatocellular carcinoma
fca05226  Gastric cancer
fca05230  Central carbon metabolism in cancer
fca05231  Choline metabolism in cancer
fca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
fca05415  Diabetic cardiomyopathy
fca05417  Lipid and atherosclerosis
fca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101093586 (PIK3R2)
   04014 Ras signaling pathway
    101093586 (PIK3R2)
   04015 Rap1 signaling pathway
    101093586 (PIK3R2)
   04370 VEGF signaling pathway
    101093586 (PIK3R2)
   04630 JAK-STAT signaling pathway
    101093586 (PIK3R2)
   04668 TNF signaling pathway
    101093586 (PIK3R2)
   04066 HIF-1 signaling pathway
    101093586 (PIK3R2)
   04068 FoxO signaling pathway
    101093586 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    101093586 (PIK3R2)
   04072 Phospholipase D signaling pathway
    101093586 (PIK3R2)
   04071 Sphingolipid signaling pathway
    101093586 (PIK3R2)
   04024 cAMP signaling pathway
    101093586 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    101093586 (PIK3R2)
   04152 AMPK signaling pathway
    101093586 (PIK3R2)
   04150 mTOR signaling pathway
    101093586 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101093586 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101093586 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    101093586 (PIK3R2)
   04218 Cellular senescence
    101093586 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101093586 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101093586 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101093586 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101093586 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    101093586 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    101093586 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    101093586 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    101093586 (PIK3R2)
   04660 T cell receptor signaling pathway
    101093586 (PIK3R2)
   04662 B cell receptor signaling pathway
    101093586 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    101093586 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    101093586 (PIK3R2)
   04670 Leukocyte transendothelial migration
    101093586 (PIK3R2)
   04062 Chemokine signaling pathway
    101093586 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101093586 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    101093586 (PIK3R2)
   04929 GnRH secretion
    101093586 (PIK3R2)
   04915 Estrogen signaling pathway
    101093586 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    101093586 (PIK3R2)
   04917 Prolactin signaling pathway
    101093586 (PIK3R2)
   04926 Relaxin signaling pathway
    101093586 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    101093586 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    101093586 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101093586 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101093586 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    101093586 (PIK3R2)
   04722 Neurotrophin signaling pathway
    101093586 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101093586 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    101093586 (PIK3R2)
   04380 Osteoclast differentiation
    101093586 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    101093586 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    101093586 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101093586 (PIK3R2)
   05206 MicroRNAs in cancer
    101093586 (PIK3R2)
   05205 Proteoglycans in cancer
    101093586 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    101093586 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101093586 (PIK3R2)
   05203 Viral carcinogenesis
    101093586 (PIK3R2)
   05230 Central carbon metabolism in cancer
    101093586 (PIK3R2)
   05231 Choline metabolism in cancer
    101093586 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101093586 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101093586 (PIK3R2)
   05212 Pancreatic cancer
    101093586 (PIK3R2)
   05225 Hepatocellular carcinoma
    101093586 (PIK3R2)
   05226 Gastric cancer
    101093586 (PIK3R2)
   05214 Glioma
    101093586 (PIK3R2)
   05221 Acute myeloid leukemia
    101093586 (PIK3R2)
   05220 Chronic myeloid leukemia
    101093586 (PIK3R2)
   05218 Melanoma
    101093586 (PIK3R2)
   05211 Renal cell carcinoma
    101093586 (PIK3R2)
   05215 Prostate cancer
    101093586 (PIK3R2)
   05213 Endometrial cancer
    101093586 (PIK3R2)
   05224 Breast cancer
    101093586 (PIK3R2)
   05222 Small cell lung cancer
    101093586 (PIK3R2)
   05223 Non-small cell lung cancer
    101093586 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101093586 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    101093586 (PIK3R2)
   05161 Hepatitis B
    101093586 (PIK3R2)
   05160 Hepatitis C
    101093586 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    101093586 (PIK3R2)
   05164 Influenza A
    101093586 (PIK3R2)
   05162 Measles
    101093586 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    101093586 (PIK3R2)
   05163 Human cytomegalovirus infection
    101093586 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101093586 (PIK3R2)
   05169 Epstein-Barr virus infection
    101093586 (PIK3R2)
   05165 Human papillomavirus infection
    101093586 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101093586 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    101093586 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101093586 (PIK3R2)
   05142 Chagas disease
    101093586 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101093586 (PIK3R2)
   05017 Spinocerebellar ataxia
    101093586 (PIK3R2)
   05020 Prion disease
    101093586 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101093586 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    101093586 (PIK3R2)
   05415 Diabetic cardiomyopathy
    101093586 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101093586 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    101093586 (PIK3R2)
   04931 Insulin resistance
    101093586 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101093586 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101093586 (PIK3R2)
   01524 Platinum drug resistance
    101093586 (PIK3R2)
   01522 Endocrine resistance
    101093586 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:fca04131]
    101093586 (PIK3R2)
Membrane trafficking [BR:fca04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101093586 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 101093586
NCBI-ProteinID: XP_023103168
LinkDB
Position
A2:13516049..13528915
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNECCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAAERTGLDSESLYRPELPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGNPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgagccgccctgcaggtg
ctgggcgtggccgagggcaacgagtgctgcccacagagcgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggccaggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagagcagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccgcggagcggacagggcta
gacagcgaatccctctacaggcctgagctgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctggtggagaagttgcttcaggaacatctggaagagcaggaggtcgcacccccagcgctg
ccgcccaaaccccccaaggccaagccagcccccgcaggcctagccaatggggggaacccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccgctcaccttctgctccgttgtggacctcatc
acccactaccgccacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacacaagagaagtgtagc
aaggagtatctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gagcaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagaccgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaggctgaggaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctccgtggtggtggac
ggcgacaccaagcactgtgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgcgggcccccgggcccggg
cccccgccggccacccgctga

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