Felis catus (domestic cat): 493698 Help Entry 493698            CDS       T02385                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 precursor   KO K10160   toll-like receptor 4 Organism fca  Felis catus (domestic cat) Pathway fca04064   NF-kappa B signaling pathway fca04066   HIF-1 signaling pathway fca04145   Phagosome fca04151   PI3K-Akt signaling pathway fca04217   Necroptosis fca04613   Neutrophil extracellular trap formation fca04620   Toll-like receptor signaling pathway fca04621   NOD-like receptor signaling pathway fca04936   Alcoholic liver disease fca05132   Salmonella infection fca05133   Pertussis fca05134   Legionellosis fca05135   Yersinia infection fca05140   Leishmaniasis fca05142   Chagas disease fca05144   Malaria fca05145   Toxoplasmosis fca05146   Amoebiasis fca05152   Tuberculosis fca05161   Hepatitis B fca05162   Measles fca05164   Influenza A fca05170   Human immunodeficiency virus 1 infection fca05171   Coronavirus disease - COVID-19 fca05205   Proteoglycans in cancer fca05235   PD-L1 expression and PD-1 checkpoint pathway in cancer fca05321   Inflammatory bowel disease fca05323   Rheumatoid arthritis fca05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     493698 (TLR4)    04066 HIF-1 signaling pathway     493698 (TLR4)    04151 PI3K-Akt signaling pathway     493698 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     493698 (TLR4)   09143 Cell growth and death    04217 Necroptosis     493698 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     493698 (TLR4)    04620 Toll-like receptor signaling pathway     493698 (TLR4)    04621 NOD-like receptor signaling pathway     493698 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     493698 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     493698 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     493698 (TLR4)    05161 Hepatitis B     493698 (TLR4)    05171 Coronavirus disease - COVID-19     493698 (TLR4)    05164 Influenza A     493698 (TLR4)    05162 Measles     493698 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     493698 (TLR4)    05135 Yersinia infection     493698 (TLR4)    05133 Pertussis     493698 (TLR4)    05134 Legionellosis     493698 (TLR4)    05152 Tuberculosis     493698 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     493698 (TLR4)    05144 Malaria     493698 (TLR4)    05145 Toxoplasmosis     493698 (TLR4)    05140 Leishmaniasis     493698 (TLR4)    05142 Chagas disease     493698 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     493698 (TLR4)    05321 Inflammatory bowel disease     493698 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     493698 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     493698 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:fca04131]     493698 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:fca04054]     493698 (TLR4)    04090 CD molecules [BR:fca04090]     493698 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:fca00536]     493698 (TLR4) Membrane trafficking [BR:fca04131]  Endocytosis   Phagocytosis    Toll-like receptors     493698 (TLR4) Pattern recognition receptors [BR:fca04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    493698 (TLR4) CD molecules [BR:fca04090]  Proteins   493698 (TLR4) Glycosaminoglycan binding proteins [BR:fca00536]  Hyaluronan   Cell surface receptors    493698 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_5 LRR_9 LRR_6 Curto_V2 ThsB_TIR Motif Other DBs NCBI-GeneID:  493698 NCBI-ProteinID:  NP_001009223 UniProt:  P58727 LinkDB All DBs Position D4:77141716..77155989 Genome browser AA seq 833 aa AA seqDB search MMPPTRLAGTLIPAMAFLSCLRPESWDPCVEVVPNITYQCMDLNLHKIPDNIPSSTKDLD MSFNPLRNLGSHSFSNFPELQVLDLSRCEIQIIEDDAYQGLNHLSILILTGNPIQRLFPG AFSGLSSLQTLVAVETNIASLEDFPIGHLKTLKELNVAHNLIHSFKLPEYFSNMSNLEYL DLSNNKIQNIYHKDLQVLHQKPLLNLSLDLSLNPLDFIQPGAFKEVKLRELTLRSNFNST DVMKASIQGLAGLQIHQLVLGEFKNERNLGRFDKSILEGLCNLIIEKFRIAYFDKFSEDA IDSFNCLANVSTISLVHLYFKGLKQLPKNLGWQRLELVNCEFEQFPTWKLDPLKELVFSA NEVRNAFTQVKLESLEFLDLSRNDFSLKSCCSERDLGTTRLKHLDLSFNNIITISSNFLG LEQLEYLDFQHSSLKQVSDFSVFLPLKNLRYLDISYTHTQVAFHGIFNGLISLQILKMAG NSFQDNFLPNIFMELTNLTILDLSDCQLEQVSQVAFNSLPKLQLLNMSHNHLLSLDTLPY EPLHSLQTLDCSFNRIVASKEQELRHFPSNLSSLNLTRNDFACVCEHQSFLQWVKDQRQL LVEVEQMVCAKPLDMQGMPMLNFRNATCQVRKTIITGSVFTVLLVFLVVVLVYKFYFHLM LLAGCKKYSRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYGIAQTWQFLSSRAGIIFIVLQKLEKSLL RQQVELYRLLNRNTYLEWEDSVLGRHIFWRRLRKALLDGKPRCPEGMADAEGS NT seq 2502 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcctacccgcctggctgggactctgatcccagccatggccttcctctcctgc ctgagacctgagagctgggacccttgtgtggaggtggttcctaacattacttaccaatgc atggacctgaatcttcacaaaatccccgacaacatcccctcatcaaccaaggacctggac atgagctttaaccccctgagaaatttaggcagccatagtttctccaacttcccagaactg caggtgctggatttatccaggtgtgaaattcaaataattgaagatgatgcatatcagggc ctaaaccacctctccatcttgatattgacaggaaatcctatccagaggttattcccagga gctttttctggactatcaagtttacagacgctggtggctgtggagacaaacatagcatct ctagaggacttccccattggacatctcaaaacgttgaaggagcttaatgtggctcacaat cttatccattccttcaaattacctgaatatttttctaacatgtccaaccttgagtatttg gatctttccaataacaagattcaaaatatttatcataaagacttacaggttctacatcaa aagcctctactcaacctttctttagacttgtccctcaaccctttagactttatccaacca ggtgcctttaaagaagttaagctccgtgaactgactttgagaagtaattttaatagtaca gatgtaatgaaagcttctattcaaggtctggcaggtttacagatccatcagttggttctg ggagaatttaaaaatgaaaggaacttgggaagatttgacaaatctatcctggagggactg tgcaatttgatcatagaaaaattccggatagcatactttgacaagttctcagaggatgct attgactcatttaattgtttggcaaacgtttctaccatttctctggtgcatctgtatttc aaggggctaaaacagctccctaaaaatctcggatggcaacggttagaattggttaactgt gaatttgaacaatttcccacatggaagctggaccctctcaaggagcttgttttctccgcc aacgaagttaggaacgcttttactcaggttaagttggaaagccttgagtttctagacctc agtagaaatgactttagtttgaagagttgctgttctgagagagatttggggacaaccaga ctgaagcatttagatctaagcttcaacaatattattaccataagttcaaacttcttgggc ttagaacagttagaatatctagacttccagcattccagtttgaaacaggtcagtgatttt tcagtattcctacccctcaaaaacctccgttaccttgatatttcttacactcatacccaa gttgccttccatggcatcttcaatggcttgatcagcctccaaatcttaaaaatggctggc aattctttccaggacaacttccttccaaatattttcatggagctgactaacttgaccatt ctagacctctctgattgtcagctggaacaggtgtcccaagtggcatttaactcactccct aaacttcagttgctaaatatgagtcacaaccacctcttatcattggatacacttccttat gaacctcttcactccctccagactctggactgcagttttaatcgtatagtggcctctaag gagcaagaactacggcattttccaagtaatctatcttccttaaatcttactcggaatgat tttgcttgtgtttgtgaacaccagagtttcctgcagtgggtcaaggaccagaggcagctc ttggtggaagttgaacagatggtgtgtgcaaaacctttggacatgcagggcatgcccatg ctgaattttaggaatgctacctgtcaggtgagaaagaccatcattactgggtcggttttc actgtactcttggtttttctggtggtggttctggtgtataagttctatttccacctgatg cttcttgctggctgtaaaaagtatagcagaggtgaaagcacctatgatgccttcgttatc tactcaagccaggatgaagattgggtgaggaatgaattggtaaagaacttggaggagggg gtgcccccttttcagctctgccttcactacagagactttattcctggtgtggccatcgcc gccaacatcatccaggaaggtttccataaaagccggaaagttatcgtcgtggtgtcccag cactttatccagagtcgatggtgcatctttgagtatgggattgcccagacttggcagttt ctcagcagccgtgccggcatcatcttcatcgtcctgcagaagttggagaagtccctgctg cggcagcaggtggagctgtatcgccttctcaacaggaacacctacctggagtgggaggac agtgtcctggggaggcacatcttctggagacgactcagaaaagccttgctggacggtaaa ccacgctgtccagaaggaatggcagatgcagaaggcagctag

Felis catus (domestic cat): 493797 Help Entry 493797            CDS       T02385                                  Symbol TLR2 Name (RefSeq) toll-like receptor 2   KO K10159   toll-like receptor 2 Organism fca  Felis catus (domestic cat) Pathway fca04145   Phagosome fca04151   PI3K-Akt signaling pathway fca04613   Neutrophil extracellular trap formation fca04620   Toll-like receptor signaling pathway fca05132   Salmonella infection fca05134   Legionellosis fca05140   Leishmaniasis fca05142   Chagas disease fca05144   Malaria fca05145   Toxoplasmosis fca05146   Amoebiasis fca05152   Tuberculosis fca05161   Hepatitis B fca05162   Measles fca05168   Herpes simplex virus 1 infection fca05169   Epstein-Barr virus infection fca05170   Human immunodeficiency virus 1 infection fca05171   Coronavirus disease - COVID-19 fca05205   Proteoglycans in cancer fca05235   PD-L1 expression and PD-1 checkpoint pathway in cancer fca05321   Inflammatory bowel disease fca05323   Rheumatoid arthritis fca05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     493797 (TLR2)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     493797 (TLR2)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     493797 (TLR2)    04620 Toll-like receptor signaling pathway     493797 (TLR2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     493797 (TLR2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     493797 (TLR2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     493797 (TLR2)    05161 Hepatitis B     493797 (TLR2)    05171 Coronavirus disease - COVID-19     493797 (TLR2)    05162 Measles     493797 (TLR2)    05168 Herpes simplex virus 1 infection     493797 (TLR2)    05169 Epstein-Barr virus infection     493797 (TLR2)   09171 Infectious disease: bacterial    05132 Salmonella infection     493797 (TLR2)    05134 Legionellosis     493797 (TLR2)    05152 Tuberculosis     493797 (TLR2)   09174 Infectious disease: parasitic    05146 Amoebiasis     493797 (TLR2)    05144 Malaria     493797 (TLR2)    05145 Toxoplasmosis     493797 (TLR2)    05140 Leishmaniasis     493797 (TLR2)    05142 Chagas disease     493797 (TLR2)   09163 Immune disease    05323 Rheumatoid arthritis     493797 (TLR2)    05321 Inflammatory bowel disease     493797 (TLR2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     493797 (TLR2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:fca04131]     493797 (TLR2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:fca04147]     493797 (TLR2)    04054 Pattern recognition receptors [BR:fca04054]     493797 (TLR2)    04090 CD molecules [BR:fca04090]     493797 (TLR2)    00536 Glycosaminoglycan binding proteins [BR:fca00536]     493797 (TLR2) Membrane trafficking [BR:fca04131]  Endocytosis   Phagocytosis    Toll-like receptors     493797 (TLR2) Exosome [BR:fca04147]  Exosomal proteins   Exosomal proteins of breast milk    493797 (TLR2) Pattern recognition receptors [BR:fca04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    493797 (TLR2) CD molecules [BR:fca04090]  Proteins   493797 (TLR2) Glycosaminoglycan binding proteins [BR:fca00536]  Hyaluronan   Cell surface receptors    493797 (TLR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR TIR_2 LRR_1 LRR_5 LRR_9 LRRCT LRR_6 Motif Other DBs NCBI-GeneID:  493797 NCBI-ProteinID:  XP_003984979 UniProt:  M3X0I5 LinkDB All DBs Position B1:complement(73801560..73813298) Genome browser AA seq 784 aa AA seqDB search MSRVLWTVWVLGAVTSLSKEVAPHQTSLSCDSTGVCEGHSRSLNSIPSGLTAAVRSLDLS NNEITYIGNSDLQGCVNLRALRLESNEINTIEEDSFFSLGSLEHLDLSYNHISNLSSSWF RPLSSLKFLNLLGNPYKSLGQTPLFSQLTTLRILKVGNIYSFTAIQEKDFAGLTFLEELE IDASNLQKYEPESLKSIQNISHLALRMKQPDLLLEIFVDLLSSVEHLELRDTHLNTLHFS KASINETNTSIKKWTFRNMKITDGSFSELVKLLNYVSGVLEVEFEDCTLHGLGDFDVSDM GKIGSVGGIETLTVRRLVIPYFYSFRDLSSVYSLTERVKRVTVESSKVFLVPCLLSQHLK SLEYLDLSDNLMVEEYLRNAACEHAWPLLQTLILRQNRLKSLEKTGETLLTLKNLINLDI SKNSYLSMPETCQWPEKLKYLNLSNTRIYSLTRCIPWTLEILDISNNNLDSFSLTLPQLK ELYISRNKLKTLPDASFLPTLQVMRISRNAINTFSKEQLDSFQRLTTLEAGGNNFICSCE FLSFTREQQALAQILTDWPDNYLCDSPFYVRGQRVQDTHLPASECHRAALVSVVCCVLFL LILLTGVLCHRFHGLWYLKMMWAWLQAKRKPRKAPQRDLCYDAFVSYSERDSHWVENLMV QELEHFEPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCKYELDFS HFRLFDENNDAVILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPTDEAQQEGFWLNLRT AIKS NT seq 2355 nt NT seq  +upstreamnt  +downstreamnt atgtcacgtgttttgtggacagtatgggtcttgggggctgtaaccagcctctccaaggaa gtggcccctcatcagacttctctgtcctgtgactccacgggcgtctgcgagggccactcc agatctttaaactccatcccttcaggactcacggcggctgtgagaagccttgacctctcc aacaatgagatcacctacattggcaacagtgacctgcagggctgtgtgaacctcagggct ctgaggctggagtctaatgaaattaacacgatagaggaagattcttttttttccctgggg agtctcgaacatttggacttatcctataatcacatatctaatttatcatcctcgtggttc aggcccctttcttccttaaagttcttaaacttgctgggaaatccttacaaatcacttggg caaacacctcttttttctcagctcacaactttgcgaattctgaaagtgggaaatatttac agtttcactgcgattcaggaaaaggattttgctgggctgacttttcttgaggaacttgag attgatgcttcaaatctccagaagtatgagccagagagtttgaagtccattcagaacatc agccatctggcccttcgtatgaaacagcctgatttgctgctggagatttttgtagatctt ttaagttctgtggaacatttggaactgagagatactcatttgaacactttacatttttca aaagcatccatcaatgaaacaaatacgtcgattaaaaagtggacgtttagaaacatgaaa atcactgatggaagttttagcgaacttgtaaaactgttgaattacgtttctggagtgtta gaagtagagtttgaggactgtactctccatgggcttggcgactttgacgtatctgacatg ggcaaaattggaagtgtaggtgggatagagacattaacagtacggaggttggtcattcca tacttctactcgtttcgtgatctgagtagtgtgtattcacttacagaaagagttaaaaga gtcacagtagaaagcagtaaggtgtttctggttccttgtttactttcacaacatttaaaa tcattagaatatttggatctcagtgacaatttaatggttgaagaatacttgagaaatgcc gcctgtgagcatgcctggcccctcctacaaaccttaattttaaggcaaaatcgtttgaaa tcattagaaaaaaccggagaaactttgcttactctgaaaaacttgattaaccttgatatt agtaagaacagttatctttctatgcctgaaacttgtcagtggccagaaaagttgaaatat ttgaacttatccaacaccagaatatacagcttaacccgatgcatcccctggacactggaa attttagatattagcaataacaatctcgattcattttctctgactttgccacaactcaaa gaactttatatttccagaaataagttgaagactctaccagatgcctccttcttacccacg ttacaggtcatgagaatcagcagaaatgcaataaacactttctctaaggagcaacttgat tcttttcaaagactgacgactttggaagctggcggcaacaatttcatttgctcctgtgaa ttcctgtctttcacgcgggagcagcaagcactggcccagatcctgaccgactggccagac aattacctgtgtgactctccattctacgtgcggggccagcgggttcaggacacccatctc ccagcttctgaatgccacagggcagctctggtgtctgtcgtgtgctgtgtccttttcctg ttgatcctgctcacgggggttctgtgccaccgtttccacgggctgtggtacctgaaaatg atgtgggcttggctccaggccaaaaggaagcccaggaaagctccccagcgggacctctgt tatgacgcctttgtgtcttacagcgagcgggattcccactgggtggagaaccttatggtc caggagctggagcacttcgagcctcccttcaagttgtgtcttcacaagcgggacttcatt cccggcaaatggattatcgacaacatcatcgactccatcgagaagagccacaaaaccatc tttgtgctttctgaaaactttgtgaagagcgagtggtgcaagtacgagctggacttctcc cacttccgtctgtttgatgagaacaacgatgctgtcattctcattcttctggagcccatt gagaaaaaggccatcccccagcgtttctgtaagctgcggaagataatgaacaccaagacc tacctggagtggcccacagacgaagctcagcaggaagggttttggttaaacttgagaact gcaataaagtcctag

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