Felis catus (domestic cat): 493939 Help Entry 493939            CDS       T02385                                  Symbol MDM2 Name (RefSeq) E3 ubiquitin-protein ligase Mdm2   KO K06643   E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] Organism fca  Felis catus (domestic cat) Pathway fca01522   Endocrine resistance fca01524   Platinum drug resistance fca04068   FoxO signaling pathway fca04110   Cell cycle fca04115   p53 signaling pathway fca04120   Ubiquitin mediated proteolysis fca04144   Endocytosis fca04151   PI3K-Akt signaling pathway fca04218   Cellular senescence fca04625   C-type lectin receptor signaling pathway fca04919   Thyroid hormone signaling pathway fca05163   Human cytomegalovirus infection fca05165   Human papillomavirus infection fca05169   Epstein-Barr virus infection fca05200   Pathways in cancer fca05202   Transcriptional misregulation in cancer fca05203   Viral carcinogenesis fca05205   Proteoglycans in cancer fca05206   MicroRNAs in cancer fca05214   Glioma fca05215   Prostate cancer fca05218   Melanoma fca05219   Bladder cancer fca05220   Chronic myeloid leukemia Brite KEGG Orthology (KO) [BR:fca00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     493939 (MDM2)  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     493939 (MDM2)    04151 PI3K-Akt signaling pathway     493939 (MDM2)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     493939 (MDM2)   09143 Cell growth and death    04110 Cell cycle     493939 (MDM2)    04115 p53 signaling pathway     493939 (MDM2)    04218 Cellular senescence     493939 (MDM2)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     493939 (MDM2)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     493939 (MDM2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     493939 (MDM2)    05202 Transcriptional misregulation in cancer     493939 (MDM2)    05206 MicroRNAs in cancer     493939 (MDM2)    05205 Proteoglycans in cancer     493939 (MDM2)    05203 Viral carcinogenesis     493939 (MDM2)   09162 Cancer: specific types    05214 Glioma     493939 (MDM2)    05220 Chronic myeloid leukemia     493939 (MDM2)    05218 Melanoma     493939 (MDM2)    05219 Bladder cancer     493939 (MDM2)    05215 Prostate cancer     493939 (MDM2)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     493939 (MDM2)    05169 Epstein-Barr virus infection     493939 (MDM2)    05165 Human papillomavirus infection     493939 (MDM2)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     493939 (MDM2)    01522 Endocrine resistance     493939 (MDM2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:fca04131]     493939 (MDM2)    04121 Ubiquitin system [BR:fca04121]     493939 (MDM2) Enzymes [BR:fca01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      493939 (MDM2) Membrane trafficking [BR:fca04131]  Endocytosis   Clathrin-mediated endocytosis    Ubiquitin E3 ligases     493939 (MDM2) Ubiquitin system [BR:fca04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    MDM2/MDM4 proteins     493939 (MDM2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  zf-C3HC4_3 Zn_ribbon_RanBP SWIB zf-RING_2 zf-FPG_IleRS Motif Other DBs NCBI-GeneID:  493939 NCBI-ProteinID:  NP_001009346 UniProt:  Q7YRZ8 Structure PDBPDBj LinkDB All DBs Position B4:93683294..93710270 Genome browser AA seq 491 aa AA seqDB search MCNTNMSVSTDGAVSTSQMPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVIFYLGQY IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQHEPSDSGT SVSENRCHLEGGSDQKDPVQELQEEKPSSSDLVSRPSTSSRRRTISETEEHSDELPGERQ RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYRVTVYQAGESDTDSFEEDPEISLA DYWKCTSCNEMNPPLPPHCNRCWALRENWLPEDKGKDKGKMPEKAKVENSTQVEEGFDVP DCKRTTVNDSRESCAEENDDKITQASQSQESEDYSQPSTSNSIIHSSQEDVKEFEREETQ DKEEIVEPSFPHNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ PIQMIVLTYFP NT seq 1476 nt NT seq  +upstreamnt  +downstreamnt atgtgcaataccaacatgtctgtgtctaccgatggtgctgtaagcacctcacagatgcca gcttcggagcaagagaccctggttagaccaaagccattgctcttgaagttgttaaagtct gttggtgcacaaaaagacacttatactatgaaagaggttatattttaccttggccagtat ataatgactaaacgattatatgatgagaagcaacagcatattgtgtattgttccaatgat ctcctaggggatttgtttggagtgccaagcttctctgtgaaagaacacaggaaaatatat acaatgatctacagaaacttggtagtagtcaatcagcatgaaccatcagattcaggcaca tctgtgagtgaaaataggtgtcaccttgaaggtgggagtgatcaaaaggaccctgtgcaa gagttgcaggaagagaaaccttcatcttcagatttggtttctagaccatctacctcatct agaaggagaacaattagtgagacagaggaacattcagatgaattacctggtgaacggcag agaaagcgccacaagtctgatagtatttctctttcctttgatgaaagtcttgctctgtgt gtaataagggagatatgttgtgaaagaagcagtagcagcgaatcaacgggcactccgtca aatccggatctcgatgctggtgtaagtgaacattcaggtgattggttggatcaggattca gtttcagatcaattcagtgtagaatttgaagttgagtctctcgattcagaagattatagc cttagtgaagaaggacaagaactctcagatgaagatgatgaggtatatcgagtaactgtg tatcaggcaggggagagtgatacagattcatttgaagaagatcctgaaatttccttagct gactattggaagtgtacttcgtgcaatgaaatgaatcctcctcttccacctcattgcaac agatgttgggctcttcgtgagaactggcttcctgaagataaagggaaagataaagggaaa atgcctgagaaagccaaagtggaaaactcaacacaagtagaagagggctttgatgtccct gattgtaaaagaactacagtgaatgattccagggaatcatgtgctgaggaaaatgatgat aaaatcacacaggcctcccaatcccaagaaagtgaggactattctcagccatcaacttct aacagcatcattcatagcagccaagaagatgtcaaagagtttgagagggaagaaacacaa gacaaagaagaaatcgtggaacctagttttccccataatgccattgaaccttgtgtgatt tgccagggtcgacctaaaaatggttgcattgttcatggcaaaacaggacatcttatggca tgctttacttgtgcaaaaaagctaaagaagaggaataagccctgtccagtatgtagacaa ccaattcaaatgattgtgctaacttatttcccctag

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