Entry |
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Symbol |
MDM2
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Name |
E3 ubiquitin-protein ligase Mdm2 [EC: 2.3.2.27]
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Pathway |
map04625 | C-type lectin receptor signaling pathway |
map04919 | Thyroid hormone signaling pathway |
map05163 | Human cytomegalovirus infection |
map05202 | Transcriptional misregulation in cancer |
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Disease |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
04151 PI3K-Akt signaling pathway
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09143 Cell growth and death
04110 Cell cycle
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
04115 p53 signaling pathway
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
04218 Cellular senescence
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09152 Endocrine system
04919 Thyroid hormone signaling pathway
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05202 Transcriptional misregulation in cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05206 MicroRNAs in cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05205 Proteoglycans in cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05203 Viral carcinogenesis
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09162 Cancer: specific types
05214 Glioma
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05220 Chronic myeloid leukemia
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05218 Melanoma
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05219 Bladder cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05215 Prostate cancer
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05169 Epstein-Barr virus infection
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
05165 Human papillomavirus infection
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09171 Infectious disease: bacterial
05131 Shigellosis
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
01522 Endocrine resistance
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
04121 Ubiquitin system
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
Enzymes [BR:ko01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
Membrane trafficking [BR:ko04131]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
Single Ring-finger type E3
MDM2/MDM4 proteins
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2
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Genes |
» show all
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Reference |
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Authors |
Tamborini E, Della Torre G, Lavarino C, Azzarelli A, Carpinelli P, Pierotti MA, Pilotti S |
Title |
Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas. |
Journal |
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Sequence |
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Reference |
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Authors |
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K |
Title |
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. |
Journal |
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Reference |
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Authors |
Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B |
Title |
Amplification of a gene encoding a p53-associated protein in human sarcomas. |
Journal |
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Sequence |
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LinkDB |
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