KEGG   Francisella tularensis subsp. holarctica F92: F92_04430
Entry
F92_04430         CDS       T02349                                 
Name
(GenBank) bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase
  KO
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
Organism
fts  Francisella tularensis subsp. holarctica F92
Pathway
fts00250  Alanine, aspartate and glutamate metabolism
fts00330  Arginine and proline metabolism
fts01100  Metabolic pathways
fts01110  Biosynthesis of secondary metabolites
Module
fts_M00970  Proline degradation, proline => glutamate
Brite
KEGG Orthology (KO) [BR:fts00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    F92_04430
   00330 Arginine and proline metabolism
    F92_04430
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:fts03000]
    F92_04430
Enzymes [BR:fts01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88  L-glutamate gamma-semialdehyde dehydrogenase
     F92_04430
  1.5  Acting on the CH-NH group of donors
   1.5.5  With a quinone or similar compound as acceptor
    1.5.5.2  proline dehydrogenase
     F92_04430
Transcription factors [BR:fts03000]
 Prokaryotic type
  Ribbon-helix-helix
   Other families
    F92_04430
SSDB
Motif
Pfam: Aldedh Pro_dh Pro_dh-DNA_bdg PRODH
Other DBs
NCBI-ProteinID: AFX70492
LinkDB
Position
787070..791134
AA seq 1354 aa
MNDLLNHSGEYPISKEIMNIYKYWLIDEKEAMTKLVEKAHMSSVQKAQVRERAYGLVEKV
RKNRLKKSGIDAFMIEYDLSSEEGVVLMCLAEALLRVPDKYTIDLLIKDKLTSAAWKNHV
GMEKHLFVNAATWSLMLTGKILKDPHRSYRKVFQNFLKKTSEPVIRQAMKQAMKIVGKQY
VLGETIEEALKVSEAKVARGYSYSYDMLGEAAMTMDDAEYYYSQYLHAIHELAKYATNTE
IKKNPGISIKLSALHPRYEVAKHQRVHTELYPKLLKLTQLAKDYNVGMNIDAEETERLQI
SLELVERLAHEPSLEGFNGIGIVVQAYQKRAPYVLDYLANLAKKTNRRFMIRLVKGAYWD
AEIKHAQEQGLAGYPVFTRKYHTDVSYQACVKQLFENHQYIYPQFATHNAQTVAVVFELA
NGNRDFEFQCLHGMGDALYDNVVGKEGYEDIPCRIYAPVGGHKHLLAYLVRRLLENGANS
SFVNRIVDENLPIEELIEDPVKKAIDHGCGQHPNIPYPKDIVSPRLNSQGHNTNDFAVLA
DMYKQIEKYTHKNTYKAKPIVSGIDLDKTITESVINPNTNEVIGSVINADAKIAKRALKN
AQSAFEEWSNTPATKRADILEKFADLLEQDTNKFIAIAMIEAGKTLANAIDEVREAVDFC
RYYAAQARKEFNGPIELPALSDHLKQIEFTGRGAMVCISPWNFPLAIFLGQITAVLAAGN
TVVAKPAEQTPIIAYKAVKLLFKAGLPKNVLQFTPGDGATVGSALVKSPVCKGVIFTGST
EVAAIINQTLANKSSEIVPFIAETGGQNAMIVDSSSLPEQVTADVIRSAFDSAGQRCSAL
RILCLQEDIADNYIKMIVGAMKELKIGDSKYIDTDVGPVIDKEAADNLNAYIEEKKSQFK
LIYQAQPNQDTQKGTFVMPTAFEIDKISDLGREQFGPILHILRFKANQLDKLINDINATG
YGLTAGVHSRINEVMNYVKNNLKAGNIYVNRNIVGAVVGVQPFGGQGKSGTGPKAGGPYY
MHRLANEKLSGVGAVEEIYNPEKIAEYEKQTNKLIKDKYTITNIVAGEKAKKDKYTNLKA
ANGKTIGKKYVASVNTVDNAIEIASKEVEIWNHVNAEQRAATIEKFLELLEKERYLIASS
LVVESNISVEDAHIQIDKTIQQVAYYCLQAKKEFAHPQLLPGPTGEIDELSLKGRGVVVS
MCSSSDLLIRFVGQTAAALLAGNTVVAKPAYTGNLTAYNIVKLMLKAGIDSKVLHLVLSD
DEEITSALLFNSKVALVSFSGSVSAVKQVHQALVLRRGAIIPFVAESIAKNGKCTSLAIE
TASPLYLRRFVVEKTVSVDTTASGGNASLMSLEE
NT seq 4065 nt   +upstreamnt  +downstreamnt
atgaatgacttactaaatcactcaggagaatatcctatttctaaagaaataatgaatata
tataaatattggcttatcgatgaaaaagaagccatgacaaagcttgttgaaaaagctcat
atgtcaagcgttcaaaaggcacaagttagagaaagggcttatggcttagtagaaaaagtc
agaaagaatagactcaaaaagtctggcattgatgcgtttatgatcgagtatgacttatca
tcagaagaaggggtagtgctgatgtgtttagctgaagcgctgctaagagtacctgataaa
tatactattgatctgcttatcaaagataagcttacaagtgctgcgtggaaaaaccatgtt
ggtatggaaaagcatctatttgttaatgctgcgacatggagtttgatgttaactggtaaa
attcttaaagatccgcatcgttcttatagaaaagtttttcaaaattttcttaaaaaaact
agtgagccagtaattcgtcaagcaatgaaacaagcaatgaaaattgttggtaagcaatat
gtacttggtgaaactatcgaagaagctctaaaggtatcagaagctaaagtagccagaggc
tatagctattcttatgatatgcttggtgaagctgcaatgacaatggatgatgctgagtac
tattatagtcagtatcttcatgcaatacatgagttagctaagtatgctacaaatacggaa
atcaaaaaaaatccaggaatttctatcaaattatctgctttacatccacgctatgaggtt
gcaaagcaccaaagagttcatacagaattatatccaaaactgcttaagcttacgcaatta
gcaaaagattataatgttgggatgaatatcgatgctgaagaaacagaaagattacaaata
tcattagaactagtagaaagactagctcatgagccatctttagaaggttttaatggtatt
ggtattgttgttcaggcataccaaaaaagagctccttatgtattagattatttagcaaat
cttgctaagaaaactaatagaagatttatgatccgcttagttaagggggcgtattgggat
gccgaaattaagcatgcgcaagagcaaggtttagcaggttatccagtatttacgcgtaaa
tatcacacagacgtctcatatcaggcttgtgttaaacagctttttgagaatcatcaatat
atctatcctcagtttgcaacgcataatgctcagactgtcgctgtagtatttgagttagct
aatggtaatagagattttgaatttcagtgtttacatggtatgggcgatgcgctatatgac
aatgtcgttggtaaagaaggctatgaagatattccatgtagaatatatgcaccagttggt
ggtcataagcatcttttagcatatctagtaagaagactgctagaaaatggtgctaatagc
tcattcgtaaatagaatagtagacgagaatttacctattgaagaattaatagaggatcct
gttaaaaaagctatcgatcatggttgtggtcagcatcctaatattccttatccaaaagat
atagtctcaccaagattaaattcacaaggtcataatactaatgattttgctgttttggct
gatatgtataagcaaatagaaaaatatacgcacaaaaatacatataaagcaaaaccgata
gtttctggtattgatcttgataaaacaattactgaaagtgttataaatccaaatactaat
gaagtcatcggtagcgtaatcaatgctgatgctaaaattgctaaaagagcactaaaaaat
gctcaaagtgcatttgaagagtggagtaatacaccagcaacaaaaagagcagatattcta
gagaaatttgctgatcttttagaacaagatactaataaatttattgctatagcaatgatt
gaagctggtaaaaccttggctaatgctatagatgaggttagagaggctgtagatttttgt
cgttattatgctgcacaagctagaaaagaatttaatggtcctattgaattgccagcttta
tcagatcatcttaagcagatagagtttaccggtcgcggagctatggtatgtattagccct
tggaatttcccattggcaatattcttaggacagataacagctgttttagcagctggtaat
acagtagttgctaaaccagcagagcagacgccaataatagcttataaggctgttaagctt
ttatttaaagctggtttacctaaaaatgttttacaatttacgcctggtgatggtgcaaca
gttggtagtgctctggttaagagcccagtatgtaaaggtgtgattttcacaggctctaca
gaggttgcagctattataaatcagactttggcaaacaaatctagtgaaatagtaccattt
attgctgagacaggtggacaaaacgctatgattgttgactcatcatcgcttcctgagcag
gttaccgcagatgtgatacgttcagcttttgatagcgcgggacaacgctgttcagcatta
cgtatcttatgtcttcaagaagatatcgctgataactatattaagatgatagttggtgca
atgaaagaacttaaaataggcgattctaaatatattgatactgatgttggtcctgtgatc
gataaagaggctgctgataatctaaatgcgtatattgaagagaaaaaaagccagtttaag
cttatatatcaagctcaacctaaccaagatacacaaaagggcacatttgtgatgcctact
gcttttgagatagataaaatatctgatttgggtagagagcagtttggtccaattttacat
atcttgcgctttaaggctaatcaactagataagcttatcaacgacatcaatgctacagga
tatggtctaacagccggtgtgcatagtcgaattaatgaagtgatgaactatgttaaaaat
aaccttaaagctggtaatatctatgtaaataggaatattgttggtgctgttgttggtgtc
caaccatttggtggtcaaggcaaatctggaacaggtcctaaagctggcggcccttattat
atgcatcgtttagctaatgaaaaattatcaggagtaggtgccgttgaagagatctacaat
cctgaaaaaatagctgaatatgaaaagcagactaacaagcttatcaaagataaatatact
atcacaaatattgttgctggtgagaaagctaaaaaagataaatatactaatcttaaagca
gcaaatggtaaaacgattggtaagaaatatgtagcttctgtgaatactgtagataatgct
atagaaattgctagtaaagaggtagagatatggaatcatgttaatgctgaacaaagagct
gccactattgagaaattcttagaactattagagaaagagcgttatttgatagcttcatct
cttgtagtggagtcaaatatttcagttgaggatgctcatatccaaatagataaaactatt
cagcaggtggcatactattgcctacaagctaaaaaagagtttgctcatccacaactttta
cctggacctacaggagagattgatgagttaagcttaaaaggtcgaggtgttgtagtaagt
atgtgttcaagttctgatttactgatcagatttgttggtcaaactgctgcggctttacta
gcgggtaatactgtagtagctaagccagcatataccggtaatttaactgcttataatatt
gttaaattaatgttaaaagcgggaatagactctaaagtacttcatctagtgttgtcagat
gatgaagagataacatcagctttattatttaatagtaaggttgcactagtttccttctct
ggtagtgtttctgcggttaaacaggttcatcaggctttagtattacgtagaggtgcgatt
ataccttttgttgctgagagtattgctaaaaatggcaaatgtacaagcttagcaatagaa
acagcttcaccattgtatttacgcaggtttgtagttgaaaaaaccgtaagtgttgataca
actgcctctggtggtaatgcttctttaatgagcctagaagaataa

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