KEGG T02442: 101129438

Gorilla gorilla gorilla (western lowland gorilla): 101129438

Entry

101129438         CDS       T02442

Symbol

ITCH

Name

(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X2

K05632

E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]

Organism

ggo Gorilla gorilla gorilla (western lowland gorilla)

Pathway

ggo04120

Ubiquitin mediated proteolysis

ggo04144

Endocytosis

ggo04330

Notch signaling pathway

ggo04668

TNF signaling pathway

ggo04932

Non-alcoholic fatty liver disease

Brite

KEGG Orthology (KO) [BR:ggo00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    101129438 (ITCH)
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    101129438 (ITCH)
   04668 TNF signaling pathway
    101129438 (ITCH)
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    101129438 (ITCH)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    101129438 (ITCH)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ggo04131]
    101129438 (ITCH)
   04121 Ubiquitin system [BR:ggo04121]
    101129438 (ITCH)
Enzymes [BR:ggo01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     101129438 (ITCH)
Membrane trafficking [BR:ggo04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    101129438 (ITCH)
Ubiquitin system [BR:ggo04121]
Ubiquitin ligases (E3)
  HECT type E3
   101129438 (ITCH)

SSDB

Motif

Pfam:

HECT WW C2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

LinkDB

Position

21:join(46611770..46611839,46626618..46626759,46630475..46630599,46631695..46631832,46642453..46642498,46656447..46656604,46658131..46658320,46660200..46660295,46663301..46663475,46667429..46667498,46675111..46675195,46679857..46679985,46687782..46687854,46689174..46689245,46693929..46694017,46695785..46695944,46696748..46696881,46697215..46697355,46705446..46705566,46706003..46706107,46708673..46708769,46718288..46718360,46721656..46721755)

AA seq 862 aa
MSDGGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
DDPEDAGAGENRRVSGNNSPSLSNGDFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE

NT seq 2589 nt +upstreamnt +downstreamnt
atgtctgacggtggatcacaacttggttcaatgggtagcctcaccatgaaatcacagctt
cagatcactgtcatctcagcaaaacttaaggaaaataagaagaattggtttggaccaagt
ccttacgtagaggtcacagtagatggacagtcaaagaagacagaaaaatgcaacaacaca
aacagtcccaagtggaagcaaccccttacagttatcgttacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaataatatgaaacttgaagaagtagttgtgactttg
cagcttggaggtgacaaagagccaacagagacaataggagacttgtcaatttgtcttgat
gggctacagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaagtgct
tctcagaatgatgatggctccagatccaaggatgaaacaagagtgagcacaaatggatca
gatgaccctgaagatgcaggagctggtgaaaataggagagtcagtgggaataattctcca
tcactctcaaatggtgattttaaaccttctagacctccaagaccttcacgaccaccacca
cccaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagtgat
gggtctagtacaggctctctgccgccgacaaatacaaatacaaatacatctgaaggagca
acatctggattaataattcctcttactatatctggaggctcaggccctaggccattaaat
cctgtaactcaagctcccttgccacctggttgggagcagagagtggaccagcacgggcga
gtttactatgtagatcatgttgagaaaagaacaacatgggatagaccagaacctctacct
cctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcaca
agaacaacgacgtggcagaggccaacactggaatccgtccggaactatgaacaatggcag
ctacagcgtagtcagcttcaaggagcaatgcagcagtttaaccagagattcatttatggg
aatcaagatttatttgctacatcacaaagtaaagaatttgatcctcttggtccattgcca
cctggatgggagaagagaacagacagcaatggcagagtatatttcgtcaaccacaacaca
cgaattacacaatgggaagaccccagaagtcaaggtcaattaaatgaaaagcccttacct
gaaggttgggaaatgagattcacagtggatggaattccatattttgtggaccacaataga
agaactaccacctatatagatccccgcacaggaaaatctgccctagacaatggacctcag
atagcctatgttcgggacttcaaagcaaaggttcagtatttccggttctggtgtcagcaa
ctggccatgccacagcacataaagattacagtgacaagaaaaacattgtttgaggattcc
tttcaacagataatgagcttcagtccccaagatctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtca
catgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgttttatt
ggcagatttattgccatggctctgttccatgggaaattcatagacacgggtttttcttta
ccattctataagcgtatcttgaacaaaccagttggactcaaggatttagaatctattgat
ccagaattttacaattctctcatctgggttaaggaaaacaatattgaggaatgtgatttg
gaaatgtacttctccgttgacaaagaaattctaggtgaaattaagagtcatgatctgaaa
cctaatggtggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatggta
gctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttctttgaaggcttt
aatgaaattcttccccagcaatatttgcaatactttgatgcaaaggaattagaggtcctt
ttatgtggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcat
tatgcgaggaccagcaaacaaatcatgtggttttggcagtttgttaaagaaattgataat
gagaagagaatgagacttctacagtttgttactggaacctgccgattgccagtaggagga
tttgctgatctcatggggagcaatggaccacagaaattctgcattgaaaaagttgggaaa
gaaaattggctacccagaagtcatacctgttttaatcgcctggacctgccaccatacaag
agctatgagcaactgaaagaaaagctgttgtttgccatagaagaaacagaaggatttgga
caagagtaa

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