KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101130978
Entry
101130978         CDS       T02442                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo01524  Platinum drug resistance
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04015  Rap1 signaling pathway
ggo04024  cAMP signaling pathway
ggo04062  Chemokine signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04068  FoxO signaling pathway
ggo04070  Phosphatidylinositol signaling system
ggo04071  Sphingolipid signaling pathway
ggo04072  Phospholipase D signaling pathway
ggo04081  Hormone signaling
ggo04140  Autophagy - animal
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04152  AMPK signaling pathway
ggo04210  Apoptosis
ggo04211  Longevity regulating pathway
ggo04213  Longevity regulating pathway - multiple species
ggo04218  Cellular senescence
ggo04360  Axon guidance
ggo04370  VEGF signaling pathway
ggo04380  Osteoclast differentiation
ggo04510  Focal adhesion
ggo04550  Signaling pathways regulating pluripotency of stem cells
ggo04611  Platelet activation
ggo04613  Neutrophil extracellular trap formation
ggo04620  Toll-like receptor signaling pathway
ggo04625  C-type lectin receptor signaling pathway
ggo04630  JAK-STAT signaling pathway
ggo04650  Natural killer cell mediated cytotoxicity
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04666  Fc gamma R-mediated phagocytosis
ggo04668  TNF signaling pathway
ggo04670  Leukocyte transendothelial migration
ggo04722  Neurotrophin signaling pathway
ggo04725  Cholinergic synapse
ggo04750  Inflammatory mediator regulation of TRP channels
ggo04810  Regulation of actin cytoskeleton
ggo04910  Insulin signaling pathway
ggo04914  Progesterone-mediated oocyte maturation
ggo04915  Estrogen signaling pathway
ggo04917  Prolactin signaling pathway
ggo04919  Thyroid hormone signaling pathway
ggo04923  Regulation of lipolysis in adipocytes
ggo04926  Relaxin signaling pathway
ggo04929  GnRH secretion
ggo04930  Type II diabetes mellitus
ggo04931  Insulin resistance
ggo04932  Non-alcoholic fatty liver disease
ggo04933  AGE-RAGE signaling pathway in diabetic complications
ggo04935  Growth hormone synthesis, secretion and action
ggo04960  Aldosterone-regulated sodium reabsorption
ggo04973  Carbohydrate digestion and absorption
ggo05010  Alzheimer disease
ggo05017  Spinocerebellar ataxia
ggo05020  Prion disease
ggo05100  Bacterial invasion of epithelial cells
ggo05135  Yersinia infection
ggo05142  Chagas disease
ggo05146  Amoebiasis
ggo05160  Hepatitis C
ggo05161  Hepatitis B
ggo05162  Measles
ggo05163  Human cytomegalovirus infection
ggo05164  Influenza A
ggo05165  Human papillomavirus infection
ggo05166  Human T-cell leukemia virus 1 infection
ggo05167  Kaposi sarcoma-associated herpesvirus infection
ggo05168  Herpes simplex virus 1 infection
ggo05169  Epstein-Barr virus infection
ggo05170  Human immunodeficiency virus 1 infection
ggo05171  Coronavirus disease - COVID-19
ggo05200  Pathways in cancer
ggo05203  Viral carcinogenesis
ggo05205  Proteoglycans in cancer
ggo05206  MicroRNAs in cancer
ggo05207  Chemical carcinogenesis - receptor activation
ggo05208  Chemical carcinogenesis - reactive oxygen species
ggo05210  Colorectal cancer
ggo05211  Renal cell carcinoma
ggo05212  Pancreatic cancer
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05218  Melanoma
ggo05220  Chronic myeloid leukemia
ggo05221  Acute myeloid leukemia
ggo05222  Small cell lung cancer
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05226  Gastric cancer
ggo05230  Central carbon metabolism in cancer
ggo05231  Choline metabolism in cancer
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05415  Diabetic cardiomyopathy
ggo05417  Lipid and atherosclerosis
ggo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101130978 (PIK3R1)
   04014 Ras signaling pathway
    101130978 (PIK3R1)
   04015 Rap1 signaling pathway
    101130978 (PIK3R1)
   04370 VEGF signaling pathway
    101130978 (PIK3R1)
   04630 JAK-STAT signaling pathway
    101130978 (PIK3R1)
   04668 TNF signaling pathway
    101130978 (PIK3R1)
   04066 HIF-1 signaling pathway
    101130978 (PIK3R1)
   04068 FoxO signaling pathway
    101130978 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    101130978 (PIK3R1)
   04072 Phospholipase D signaling pathway
    101130978 (PIK3R1)
   04071 Sphingolipid signaling pathway
    101130978 (PIK3R1)
   04024 cAMP signaling pathway
    101130978 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    101130978 (PIK3R1)
   04152 AMPK signaling pathway
    101130978 (PIK3R1)
   04150 mTOR signaling pathway
    101130978 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101130978 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101130978 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    101130978 (PIK3R1)
   04218 Cellular senescence
    101130978 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101130978 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101130978 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101130978 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101130978 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    101130978 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    101130978 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    101130978 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    101130978 (PIK3R1)
   04660 T cell receptor signaling pathway
    101130978 (PIK3R1)
   04662 B cell receptor signaling pathway
    101130978 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    101130978 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    101130978 (PIK3R1)
   04670 Leukocyte transendothelial migration
    101130978 (PIK3R1)
   04062 Chemokine signaling pathway
    101130978 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101130978 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    101130978 (PIK3R1)
   04929 GnRH secretion
    101130978 (PIK3R1)
   04915 Estrogen signaling pathway
    101130978 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    101130978 (PIK3R1)
   04917 Prolactin signaling pathway
    101130978 (PIK3R1)
   04926 Relaxin signaling pathway
    101130978 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    101130978 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    101130978 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101130978 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101130978 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    101130978 (PIK3R1)
   04722 Neurotrophin signaling pathway
    101130978 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101130978 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    101130978 (PIK3R1)
   04380 Osteoclast differentiation
    101130978 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    101130978 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    101130978 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101130978 (PIK3R1)
   05206 MicroRNAs in cancer
    101130978 (PIK3R1)
   05205 Proteoglycans in cancer
    101130978 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    101130978 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101130978 (PIK3R1)
   05203 Viral carcinogenesis
    101130978 (PIK3R1)
   05230 Central carbon metabolism in cancer
    101130978 (PIK3R1)
   05231 Choline metabolism in cancer
    101130978 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101130978 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101130978 (PIK3R1)
   05212 Pancreatic cancer
    101130978 (PIK3R1)
   05225 Hepatocellular carcinoma
    101130978 (PIK3R1)
   05226 Gastric cancer
    101130978 (PIK3R1)
   05214 Glioma
    101130978 (PIK3R1)
   05221 Acute myeloid leukemia
    101130978 (PIK3R1)
   05220 Chronic myeloid leukemia
    101130978 (PIK3R1)
   05218 Melanoma
    101130978 (PIK3R1)
   05211 Renal cell carcinoma
    101130978 (PIK3R1)
   05215 Prostate cancer
    101130978 (PIK3R1)
   05213 Endometrial cancer
    101130978 (PIK3R1)
   05224 Breast cancer
    101130978 (PIK3R1)
   05222 Small cell lung cancer
    101130978 (PIK3R1)
   05223 Non-small cell lung cancer
    101130978 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101130978 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    101130978 (PIK3R1)
   05161 Hepatitis B
    101130978 (PIK3R1)
   05160 Hepatitis C
    101130978 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    101130978 (PIK3R1)
   05164 Influenza A
    101130978 (PIK3R1)
   05162 Measles
    101130978 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    101130978 (PIK3R1)
   05163 Human cytomegalovirus infection
    101130978 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101130978 (PIK3R1)
   05169 Epstein-Barr virus infection
    101130978 (PIK3R1)
   05165 Human papillomavirus infection
    101130978 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101130978 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    101130978 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101130978 (PIK3R1)
   05142 Chagas disease
    101130978 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101130978 (PIK3R1)
   05017 Spinocerebellar ataxia
    101130978 (PIK3R1)
   05020 Prion disease
    101130978 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101130978 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    101130978 (PIK3R1)
   05415 Diabetic cardiomyopathy
    101130978 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101130978 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    101130978 (PIK3R1)
   04931 Insulin resistance
    101130978 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101130978 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101130978 (PIK3R1)
   01524 Platinum drug resistance
    101130978 (PIK3R1)
   01522 Endocrine resistance
    101130978 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ggo04131]
    101130978 (PIK3R1)
Membrane trafficking [BR:ggo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101130978 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Laminin_I PI_PP_I Bap31_Bap29_C Exonuc_VII_L Transcrip_act
Other DBs
NCBI-GeneID: 101130978
NCBI-ProteinID: XP_004058804
Ensembl: ENSGGOG00000004248
UniProt: A0A2I2ZF31
LinkDB
Position
19:complement(join(41951086..41951275,41952343..41952513,41953196..41953264,41953360..41953536,41953762..41953904,41954606..41954731,41954957..41955137,41955241..41955339,41956085..41956187,41957624..41957729))
AA seq 454 aa
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTVANNGMNNNMSLQD
AEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY
GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE
KFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL
IQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSN
RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSS
LKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgtacaatactgtttggaatatggaagacctggatttagaatatgccaagacagatata
aattgtggcacagacttgatgttttatatagaaatggacccaccagcactgcctcctaaa
ccaccaaaacccactactgtagccaacaacggtatgaataacaatatgtccttacaagat
gctgaatggtactggggagatatctcgagggaagaagtgaatgaaaaacttcgagacaca
gcagacgggacctttttggtacgagatgcgtctactaaaatgcatggtgattatactctt
acactaaggaaagggggaaataacaaattaatcaaaatatttcatcgagatgggaaatat
ggcttctctgacccattaaccttcaattctgtggttgaattaataaaccactaccggaat
gaatctctagctcagtataatcccaaattggatgtgaaattactttatccagtatccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtagggaaaaaattacat
gaatataacactcagtttcaagaaaaaagtcgagaatatgatagattatatgaagaatat
acccgcacatcccaggaaatccaaatgaaaaggacagctattgaagcatttaatgaaacc
ataaagatatttgaagaacagtgccagacccaagagcggtacagcaaagaatacatagaa
aagtttaaacgtgaaggcaatgagaaagaaatacaaaggattatgcataattatgataag
ttgaagtctcgaatcagtgaaattattgacagtagaagaagattggaagaagacttgaag
aagcaggcagctgagtatcgagaaattgacaaacgtatgaacagcattaaaccagacctt
atccagctgagaaagacgagagaccaatacttgatgtggttgactcaaaaaggtgttcgg
caaaagaagttgaacgagtggttgggcaatgaaaacactgaagaccaatattcactggtg
gaagatgatgaagatttgccccatcatgatgagaagacatggaatgttggaagcagcaac
cgaaacaaagctgaaaacctgttgcgagggaagcgagatggcacttttcttgtccgggag
agcagtaaacagggctgctacgcctgctctgtagtggtggacggcgaagtaaagcattgt
gtcataaacaaaacagcaactggctatggctttgccgagccctataacttgtacagctct
ctgaaagaactggtgctacattaccaacacacctccctcgtgcagcacaacgactccctc
aatgtcacactagcctacccagtatatgcacagcagaggcgatga

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