KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101135199
Entry
101135199         CDS       T02442                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00562  Inositol phosphate metabolism
ggo01100  Metabolic pathways
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04015  Rap1 signaling pathway
ggo04020  Calcium signaling pathway
ggo04062  Chemokine signaling pathway
ggo04064  NF-kappa B signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04070  Phosphatidylinositol signaling system
ggo04072  Phospholipase D signaling pathway
ggo04360  Axon guidance
ggo04370  VEGF signaling pathway
ggo04613  Neutrophil extracellular trap formation
ggo04650  Natural killer cell mediated cytotoxicity
ggo04658  Th1 and Th2 cell differentiation
ggo04659  Th17 cell differentiation
ggo04660  T cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04666  Fc gamma R-mediated phagocytosis
ggo04670  Leukocyte transendothelial migration
ggo04722  Neurotrophin signaling pathway
ggo04750  Inflammatory mediator regulation of TRP channels
ggo04919  Thyroid hormone signaling pathway
ggo04933  AGE-RAGE signaling pathway in diabetic complications
ggo04935  Growth hormone synthesis, secretion and action
ggo05012  Parkinson disease
ggo05022  Pathways of neurodegeneration - multiple diseases
ggo05135  Yersinia infection
ggo05167  Kaposi sarcoma-associated herpesvirus infection
ggo05170  Human immunodeficiency virus 1 infection
ggo05171  Coronavirus disease - COVID-19
ggo05200  Pathways in cancer
ggo05205  Proteoglycans in cancer
ggo05206  MicroRNAs in cancer
ggo05214  Glioma
ggo05223  Non-small cell lung cancer
ggo05225  Hepatocellular carcinoma
ggo05231  Choline metabolism in cancer
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05417  Lipid and atherosclerosis
Module
ggo_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101135199 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101135199 (PLCG1)
   04014 Ras signaling pathway
    101135199 (PLCG1)
   04015 Rap1 signaling pathway
    101135199 (PLCG1)
   04370 VEGF signaling pathway
    101135199 (PLCG1)
   04064 NF-kappa B signaling pathway
    101135199 (PLCG1)
   04066 HIF-1 signaling pathway
    101135199 (PLCG1)
   04020 Calcium signaling pathway
    101135199 (PLCG1)
   04070 Phosphatidylinositol signaling system
    101135199 (PLCG1)
   04072 Phospholipase D signaling pathway
    101135199 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101135199 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    101135199 (PLCG1)
   04660 T cell receptor signaling pathway
    101135199 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    101135199 (PLCG1)
   04659 Th17 cell differentiation
    101135199 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    101135199 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    101135199 (PLCG1)
   04670 Leukocyte transendothelial migration
    101135199 (PLCG1)
   04062 Chemokine signaling pathway
    101135199 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101135199 (PLCG1)
   04919 Thyroid hormone signaling pathway
    101135199 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101135199 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101135199 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    101135199 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101135199 (PLCG1)
   05206 MicroRNAs in cancer
    101135199 (PLCG1)
   05205 Proteoglycans in cancer
    101135199 (PLCG1)
   05231 Choline metabolism in cancer
    101135199 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101135199 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101135199 (PLCG1)
   05214 Glioma
    101135199 (PLCG1)
   05223 Non-small cell lung cancer
    101135199 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101135199 (PLCG1)
   05171 Coronavirus disease - COVID-19
    101135199 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101135199 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101135199 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101135199 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    101135199 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101135199 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101135199 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101135199 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ggo04131]
    101135199 (PLCG1)
Enzymes [BR:ggo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101135199 (PLCG1)
Membrane trafficking [BR:ggo04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101135199 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101135199 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 101135199
NCBI-ProteinID: XP_018872524
Ensembl: ENSGGOG00000007808
LinkDB
Position
21:join(53362921..53363137,53384789..53384941,53385053..53385146,53385289..53385336,53387637..53387721,53387827..53387910,53388140..53388174,53388385..53388457,53388560..53388661,53388897..53389015,53389098..53389183,53389258..53389378,53390110..53390278,53390422..53390544,53390627..53390728,53390816..53391003,53391370..53391570,53391652..53391771,53391855..53392035,53393027..53393104,53393943..53394046,53394255..53394351,53394633..53394702,53395288..53395445,53397378..53397474,53397604..53397828,53397912..53398060,53398603..53398996,53399106..53399194,53399307..53399494,53399650..53399692)
AA seq 1330 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLHVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVGQSVFPVIL
LILLGHCKPLPTSHPILSQGDLKPFVVAFTVDNGLNPVWPAKPFHFQISNPEFAFLRFVV
YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKQENGDL
SPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPR
RTRVNGDNRL
NT seq 3993 nt   +upstreamnt  +downstreamnt
atggcgggcgcagcgtccccttgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatcgagggggccattgacattcgtgaaattaaggag
atccgcccagggaagacctcacgggactttgatcgctatcaagaggacccagctttccgg
ccggaccagtcacattgctttgtcattctctatggaatggaatttcgcctgaaaacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtgaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccacgtgcaggagttcatgctcagcttc
ctccgagaccccttacgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggatgcagtatgcccggac
accatgaacaaccctctttcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagtgagtcatccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccggatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcacaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccaatacttcaagaaggtgctgggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactctatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactactttgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcgtcacatcgctgagcgcctgcttactgagtactgcatcgagaccggagcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcccggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacgcactaccag
caggtgcccctgcgctgtaatgagtttgagatgcgactttcagagcctgtcccacagacc
aacgcccacgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctaatgcgcgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgagggcaagatcaagcattgccgtgtccagcaagag
ggccagacagtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaaacacccgctataccgcaagatgaagctgcgctatcccatcaacgaggaggca
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctctgg
ttcccatcaaactacgtggaagagatggtcaaccctgtggccctggagccggagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagattgccctggagctctctgaacttgtcgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagcttgtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggccctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctattgaggtgctgggggctcgacatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtgggtcagtctgtcttcccagtcatcctc
ctcatcctgctggggcactgcaagcccctccccaccagtcatcccatcctctcccagggt
gacctgaagccttttgtcgttgccttcacagtggacaatggactcaaccctgtatggcca
gccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgcttcgtggtg
tatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccagtaaaa
ggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctggag
ttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgacctc
agtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctgttt
cacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggacttc
cgcatctcccaggagcatctcgcagaccattttgacagtcgagaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag

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