Gorilla gorilla gorilla (western lowland gorilla): 101141070
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Entry
101141070 CDS
T02442
Name
(RefSeq) LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
ggo
Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00140
Steroid hormone biosynthesis
ggo01100
Metabolic pathways
ggo04913
Ovarian steroidogenesis
ggo04925
Aldosterone synthesis and secretion
ggo04927
Cortisol synthesis and secretion
ggo04934
Cushing syndrome
Module
ggo_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ggo_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ggo_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ggo_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
ggo00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
101141070
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
101141070
04925 Aldosterone synthesis and secretion
101141070
04927 Cortisol synthesis and secretion
101141070
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101141070
Enzymes [BR:
ggo01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
101141070
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
101141070
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GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
Polysacc_synt_2
GDP_Man_Dehyd
NAD_binding_10
RmlD_sub_bind
NmrA
KR
Ldh_1_N
Motif
Other DBs
NCBI-GeneID:
101141070
NCBI-ProteinID:
XP_063552047
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All DBs
Position
1:join(123824206..123824350,123828161..123828325,123830556..123831622)
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AA seq
458 aa
AA seq
DB search
MTGWSCLVTGAGGFLGQRIICLLVEETELKEIRALDRAFRPGLREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVVIHTACITDVFGVTHRQSIMNVNVKGTQLLLEACVQATVPVF
IYTSTLQLAGPNSYKEIIENAHEDDLLENTWSAPYPYSKKLAEKAVLAANGWTLKNGDTL
YTCALRPTYIYGEGGPFLSANINEALNNNGILSSVSKFSTANPVYVGNVAWAHILALRAL
WDPKKAPSVLGQFYYISDDTPHQSYDNLNYILSKEFGLCLDSRXSLLLSLMYWIGFLLEI
VSLLLRPICTYQPPFDCHTVTLSNSMFTFSYKKAQRDLAYKPLYSWEEAKQKTMEWVGSL
VDRHKENLKSKTQCFKDDRDVHVGIVRRCHQAPSSWLHIECDKGISPGPAASLSHNAQLI
VFLVSSKPAHSLTQPEAFCPNHTPEDRQCDLLFPNLSG
NT seq
1377 nt
NT seq
+upstream
nt +downstream
nt
atgacaggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcctgttagtggaggagacagagctgaaggagatcagggccttggacagggccttcaga
ccaggattgagggaggaattttctaaactccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtcgtcatc
cacaccgcctgtatcactgatgtcttcggagtcactcacagacagtctatcatgaatgtc
aatgtgaaaggtacgcagctcctgttggaggcctgtgtccaagctactgtgccagtcttc
atctacaccagtaccctacagttagccgggcccaactcctacaaggaaatcattgagaat
gcccatgaagatgaccttctggaaaacacatggtctgctccatatccatacagcaaaaag
cttgctgagaaggctgtgctggcagctaatgggtggactctgaaaaatggtgataccttg
tacacttgtgccttaagacccacgtatatctatggggaaggaggcccattcctttctgcc
aatataaatgaggccctgaacaacaatgggatcctgtcgagtgtcagcaagttctccaca
gccaacccagtctatgttggcaacgtggcctgggcccacattctggccttgagggccctg
tgggaccccaagaaggccccaagtgtcctaggacagttctactacatctcagatgacacg
cctcaccaaagctatgataaccttaattacatcctgagcaaagagttcggcctctgcctt
gattccagatgaagccttcttttatccctgatgtactggattggcttcctgctggaaata
gtgagcctcctgctcaggccaatttgcacctatcaaccgcccttcgactgccacacagtg
acattgtcaaatagcatgttcaccttctcttacaagaaggctcagcgagatctggcatat
aagccactttacagctgggaggaagccaagcagaaaaccatggagtgggttggttccctt
gtggaccggcacaaggagaacctgaagtccaagactcagtgctttaaggatgacagagat
gtgcatgtgggtattgttaggagatgtcatcaagctccatcctcctggcttcatatagaa
tgtgacaagggcataagcccaggtcctgctgcctccctttcacacaatgcccaacttatt
gtcttcctcgtgtcatcaaaacctgcccattccctgacccaaccggaagctttctgtcct
aatcatacaccagaggacagacaatgtgatttgctttttccaaatctcagtggctga
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