KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101147526
Entry
101147526         CDS       T02442                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00562  Inositol phosphate metabolism
ggo01100  Metabolic pathways
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo04068  FoxO signaling pathway
ggo04070  Phosphatidylinositol signaling system
ggo04071  Sphingolipid signaling pathway
ggo04115  p53 signaling pathway
ggo04140  Autophagy - animal
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04218  Cellular senescence
ggo04510  Focal adhesion
ggo04931  Insulin resistance
ggo05165  Human papillomavirus infection
ggo05166  Human T-cell leukemia virus 1 infection
ggo05200  Pathways in cancer
ggo05206  MicroRNAs in cancer
ggo05208  Chemical carcinogenesis - reactive oxygen species
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05218  Melanoma
ggo05222  Small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05230  Central carbon metabolism in cancer
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101147526 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    101147526 (PTEN)
   04070 Phosphatidylinositol signaling system
    101147526 (PTEN)
   04071 Sphingolipid signaling pathway
    101147526 (PTEN)
   04151 PI3K-Akt signaling pathway
    101147526 (PTEN)
   04150 mTOR signaling pathway
    101147526 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101147526 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    101147526 (PTEN)
   04218 Cellular senescence
    101147526 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101147526 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101147526 (PTEN)
   05206 MicroRNAs in cancer
    101147526 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    101147526 (PTEN)
   05230 Central carbon metabolism in cancer
    101147526 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101147526 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101147526 (PTEN)
   05214 Glioma
    101147526 (PTEN)
   05218 Melanoma
    101147526 (PTEN)
   05215 Prostate cancer
    101147526 (PTEN)
   05213 Endometrial cancer
    101147526 (PTEN)
   05224 Breast cancer
    101147526 (PTEN)
   05222 Small cell lung cancer
    101147526 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101147526 (PTEN)
   05165 Human papillomavirus infection
    101147526 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    101147526 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    101147526 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101147526 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ggo01009]
    101147526 (PTEN)
Enzymes [BR:ggo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     101147526 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     101147526 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     101147526 (PTEN)
Protein phosphatases and associated proteins [BR:ggo01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    101147526 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 101147526
NCBI-ProteinID: XP_018890663
Ensembl: ENSGGOG00000000893
LinkDB
Position
8:join(100192870..100192948,100222412..100222496,100259353..100259396,100261325..100261563,100280102..100280243,100285813..100285979,100288846..100289070,100293318..100293503)
AA seq 388 aa
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVSCAERH
YDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMI
CAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLF
HKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKV
EFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEY
LVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPD
HYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1167 nt   +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaagttgtgctgaaagacat
tatgacaccgccaaatttaattgcagagttgcacaatatccttttgaagaccataaccca
ccacagctagaacttatcaaacccttttgtgaagatcttgaccaatggctaagtgaagat
gacaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggtgtaatgatt
tgtgcatatttattacatcggggcaaatttttaaaggcacaagaggccctagatttctat
ggggaagtaaggaccagagacaaaaagggagtaactattcccagtcagaggcgctatgtg
tattattatagctacctgttaaagaatcatctggattatagaccagtggcactgttgttt
cacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaatcctcagttt
gtggtctgccagctaaaggtgaagatatattcctccaattcaggacccacacgacgggaa
gacaagttcatgtactttgagttccctcagccgttacctgtgtgtggtgatatcaaagta
gagttcttccacaaacagaacaagatgctaaaaaaggacaaaatgtttcacttttgggta
aatacattcttcataccaggaccagaggaaacctcagaaaaagtagaaaatggaagtcta
tgtgatcaagaaatcgatagcatttgcagtatagagcgtgcagataatgacaaggaatat
ctagtactcactttaacaaaaaatgatcttgacaaagcaaataaagacaaagccaaccga
tacttttctccaaattttaaggtgaagctgtacttcacaaaaacagtagaggagccgtca
aatccagaggctagcagttcaacttctgtaacaccagatgttagtgacaatgaacctgat
cattatagatattctgacaccactgactctgatccagagaatgaaccttttgatgaagat
cagcatacacaaattacaaaagtctga

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