KEGG   ORTHOLOGY: K01110
Entry
K01110                      KO                                     

Symbol
PTEN
Name
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04068  FoxO signaling pathway
map04070  Phosphatidylinositol signaling system
map04071  Sphingolipid signaling pathway
map04115  p53 signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04212  Longevity regulating pathway - worm
map04218  Cellular senescence
map04361  Axon regeneration
map04510  Focal adhesion
map04931  Insulin resistance
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05222  Small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05230  Central carbon metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05415  Diabetic cardiomyopathy
Disease
H00013  Small cell lung cancer
H00024  Prostate cancer
H00026  Endometrial cancer
H00029  Vulvar cancer
H00031  Breast cancer
H00038  Melanoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H00539  PTEN hamartoma tumor syndrome
H01195  VACTERL/VATER association
H01222  Cowden syndrome
H01463  Mycosis fungoides
H01556  Meningioma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04070 Phosphatidylinositol signaling system
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04071 Sphingolipid signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04151 PI3K-Akt signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04150 mTOR signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09143 Cell growth and death
   04115 p53 signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04218 Cellular senescence
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09149 Aging
   04212 Longevity regulating pathway - worm
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05206 MicroRNAs in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05208 Chemical carcinogenesis - reactive oxygen species
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05230 Central carbon metabolism in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05214 Glioma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05218 Melanoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05215 Prostate cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05213 Endometrial cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05224 Breast cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05222 Small cell lung cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05165 Human papillomavirus infection
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.48  protein-tyrosine-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Other DBs
RN: R03363 R04513
GO: 0004722 0004725 0008138 0016314 0051800
Genes
HSA: 5728(PTEN)
PTR: 466142(PTEN)
PPS: 100983152(PTEN)
GGO: 101147526(PTEN)
PON: 100171828(PTEN)
NLE: 100605147(PTEN)
MCC: 705121(PTEN)
MCF: 101867036(PTEN)
CSAB: 103216211(PTEN)
CATY: 105587171(PTEN)
PANU: 101016586(PTEN)
RRO: 104675158(PTEN)
RBB: 108527540(PTEN)
TFN: 117086074(PTEN)
PTEH: 111551321(PTEN)
CJC: 100393460(PTEN)
SBQ: 101039215(PTEN)
MMUR: 105857697 105870314(PTEN)
MMU: 19211(Pten)
MCAL: 110285202(Pten)
MPAH: 110312812(Pten)
RNO: 50557(Pten)
MCOC: 116103746(Pten)
MUN: 110561175(Pten)
CGE: 100764294(Pten)
NGI: 103738044(Pten)
HGL: 101714930(Pten)
CCAN: 109689440(Pten) 109689441
OCU: 100358716(PTEN)
OPI: 101529935(PTEN)
TUP: 102489114(PTEN)
CFA: 403832(PTEN)
VVP: 112931976(PTEN)
VLG: 121475822(PTEN)
AML: 100469483(PTEN)
UMR: 103661921(PTEN)
UAH: 113258976(PTEN)
ORO: 101367385(PTEN)
ELK: 111144778
MPUF: 101670064(PTEN)
EJU: 114210280(PTEN) 114210281
MLX: 118012969(PTEN)
FCA: 101091813(PTEN)
PYU: 121016570(PTEN)
PBG: 122493436(PTEN)
PTG: 102972446(PTEN)
PPAD: 109255395(PTEN)
AJU: 106980972(PTEN)
HHV: 120235953(PTEN)
BTA: 540786(PTEN)
BOM: 102268478(PTEN)
BIU: 109552991(PTEN)
BBUB: 102405361(PTEN)
CHX: 102185891(PTEN)
OAS: 101119351(PTEN)
ODA: 120873785(PTEN)
CCAD: 122446193(PTEN)
SSC: 100156264(PTEN)
CFR: 102515104(PTEN)
CBAI: 105081861(PTEN)
CDK: 105088956(PTEN)
BACU: 102998704(PTEN)
LVE: 103074298(PTEN)
OOR: 101289838(PTEN)
DLE: 111172530(PTEN)
PCAD: 102984551(PTEN)
ECB: 100062388(PTEN)
EPZ: 103561454(PTEN)
EAI: 106845897(PTEN)
MYB: 102257838(PTEN)
MYD: 102755323(PTEN)
MMYO: 118670001(PTEN) 118677363
MNA: 107543303(PTEN)
PKL: 118719258(PTEN)
HAI: 109387530(PTEN)
DRO: 112307354(PTEN)
SHON: 118988011(PTEN)
AJM: 119057730(PTEN)
MMF: 118632142(PTEN)
PALE: 102881949(PTEN)
PGIG: 120609356(PTEN)
RAY: 107501760(PTEN)
MJV: 108397450(PTEN)
TOD: 119234402(PTEN)
LAV: 100660561(PTEN)
TMU: 101355243
MDO: 100013036(PTEN)
GAS: 123233053(PTEN)
SHR: 100927199(PTEN)
PCW: 110199935(PTEN)
OAA: 100074365(PTEN)
GGA: 423675(PTEN)
PCOC: 116234768(PTEN)
MGP: 100541251(PTEN)
CJO: 107315619(PTEN)
NMEL: 110390505(PTEN)
APLA: 101798136(PTEN)
ACYG: 106030781(PTEN)
TGU: 100224148(PTEN)
LSR: 110474026(PTEN)
SCAN: 103814071(PTEN)
PMOA: 120499692(PTEN)
OTC: 121336046(PTEN)
PRUF: 121356527(PTEN)
GFR: 102039901(PTEN)
FAB: 101815785(PTEN)
PHI: 102106703(PTEN)
PMAJ: 107206954(PTEN)
CCAE: 111931632(PTEN)
CCW: 104695072(PTEN)
ETL: 114069647(PTEN)
FPG: 101912177(PTEN)
FCH: 102050194(PTEN)
CLV: 102094724(PTEN)
EGZ: 104125131(PTEN)
NNI: 104013521(PTEN)
ACUN: 113481870(PTEN)
PADL: 103924277(PTEN)
AAM: 106495308(PTEN)
AROW: 112973293(PTEN)
NPD: 112948417(PTEN)
DNE: 112981607(PTEN)
ASN: 106721809(PTEN)
AMJ: 102558284(PTEN)
CPOO: 109312531(PTEN)
GGN: 109290926(PTEN)
PSS: 102443573(PTEN)
CMY: 102941367(PTEN)
CPIC: 101934509(PTEN)
TST: 117880573(PTEN)
CABI: 116819003(PTEN)
ACS: 100552870(pten)
PVT: 110083120(PTEN)
PBI: 103059990
PMUR: 107285111(PTEN)
TSR: 106555545(PTEN)
PGUT: 117670637(PTEN)
VKO: 123018466(PTEN)
PMUA: 114597278(PTEN)
ZVI: 118096089(PTEN)
GJA: 107120016(PTEN) 107121111
XLA: 100505440(pten.S) 399142(pten.L)
XTR: 100144716(pten)
NPR: 108788861(PTEN)
DRE: 368415(ptenb) 794088(ptena)
IPU: 108269686 108273661(pten)
PHYP: 113527326(pten) 113547721
AMEX: 103025186(pten) 103046962
EEE: 113579468(pten) 113590406
TRU: 101079654(pten)
LCO: 104929647 104936542(pten)
NCC: 104956663(pten)
CGOB: 115020008(pten) 115024979
ELY: 117246921(ptenb) 117248395
PLEP: 121954358(ptena) 121958959
SLUC: 116055194 116059244(ptenb)
ECRA: 117960373(ptena)
GAT: 120819653(ptenb) 120820607
PPUG: 119212840(ptenb) 119214113(ptena)
MSAM: 119884419 119917190(ptena)
CUD: 121510932(ptena) 121527879(ptenb)
OAU: 116324422(ptenb) 116333805
OLA: 101171856(pten) 101173689
OML: 112141857(ptenb) 112162087(ptena)
XMA: 102226067(pten) 102236680
XHE: 116713427(pten) 116727299
PRET: 103476793 103482129(pten)
CVG: 107094800 107102082(pten)
CTUL: 119790844 119792869(ptenb)
NFU: 107376033 107387492(pten)
KMR: 108229273(ptenb) 108245338
ALIM: 106513467 106528198(pten)
CSEM: 103382250(pten) 103387686
POV: 109634811(pten) 109644901
XGL: 120794730(ptenb) 120796639(ptena)
MALB: 109960336(pten) 109969673
ELS: 105006284(pten) 105010650
SFM: 108932873 108939683(pten)
PKI: 111853698(pten) 111858884
AANG: 118218023 118220705(ptenb)
LOC: 102685186(pten)
LCM: 102348548(PTEN)
CMK: 103180851(ptenb)
RTP: 109913977(pten)
BFO: 118411114
BBEL: 109485401
CIN: 100182434
SCLV: 120346935
SKO: 100313711(Pten)
DME: Dmel_CG5671(Pten)
DER: 6541174
DSE: 6611942
DSI: Dsimw501_GD22287(Dsim_GD22287)
DAN: 6496952
DSR: 110183295
DPE: 6589679
DMN: 108161604
DWI: 6642648
DGR: 6567003
DAZ: 108620387
DNV: 115565115
DHE: 111594667
DVI: 6629131
MDE: 101892103
LCQ: 111680908
ACOZ: 120959930
AAG: 23687644
CPII: 120413114
AME: 411859(Pten)
ACER: 107998634
BIM: 100743534
BBIF: 117210693
BVK: 117237533
BVAN: 117164124
BTER: 100643227
CCAL: 108628117
OBB: 114877623
MGEN: 117217897
NMEA: 116434891
SOC: 105195960
MPHA: 105835031
AEC: 105148783
ACEP: 105619919
PBAR: 105426787
VEM: 105558562
HST: 105192370
DQU: 106748504
CFO: 105253074
FEX: 115235195
LHU: 105670175
PGC: 109856638
OBO: 105284147
PCF: 106786252
PFUC: 122525351
NVI: 100117148(Pten)
CSOL: 105368591
TPRE: 106650074
MDL: 103571159
FAS: 105267389
DAM: 107039002
CCIN: 107271988
TCA: 663870
DPA: 109542185
ATD: 109597493
AGB: 108904012
LDC: 111517429
NVL: 108566279
APLN: 108733636
PPYR: 116173284
OTU: 111413564
BMOR: 101745952
BMAN: 114242428
MSEX: 115441808
BANY: 112050643
PMAC: 106718558
PPOT: 106110694
PXU: 106126794
PRAP: 110993954
ZCE: 119840251
HAW: 110373249
TNL: 113497664
API: 100163194
DNX: 107172228
AGS: 114128348
RMD: 113555800
BTAB: 109039093
DCI: 103524450
CLEC: 106665060
HHAL: 106685077
NLU: 111047065
FOC: 113218274
ZNE: 110831106
CSEC: 111871175
FCD: 110842984
DMK: 116929116
PVM: 113829491
PJA: 122248687
HAME: 121877846
EAF: 111704033
DSV: 119436865
RSAN: 119396881
VDE: 111245665
VJA: 111261763
TUT: 107359492
DPTE: 113794406
CSCU: 111622749
PTEP: 107437787
CEL: CELE_T07A9.6(daf-18)
CBR: CBG13540(Cbr-daf-18)
BMY: BM_BM5630(Bma-daf-18)
TSP: Tsp_07635
PCAN: 112577354
BGT: 106074175
GAE: 121380074
CRG: 105331286
MYI: 110464227
PMAX: 117336462
OBI: 106873013
OSN: 115224373
LAK: 106162681
EGL: EGR_01192
NVE: 5504087
EPA: 110254143
ATEN: 116302926
ADF: 107346271
AMIL: 114954557
PDAM: 113666418
DGT: 114531075
AQU: 100640061
ATH: AT3G19420(PEN2) AT3G50110(PEN3) AT5G39400(PTEN1)
LJA: Lj1g3v2995580.1(Lj1g3v2995580.1) Lj2g3v1904480.1(Lj2g3v1904480.1) Lj5g3v2133750.1(Lj5g3v2133750.1)
OSA: 4352052
DOSA: Os12t0407500-01(Os12g0407500)
OBR: 102704853
BDI: 100846535
ATS: 109747383
SBI: 8054522
ZMA: 103648286
SITA: 101758319
PHAI: 112879773
SCE: YNL128W(TEP1)
ERC: Ecym_8193
KMX: KLMA_60260(TEP1)
NCS: NCAS_0G02390(NCAS0G02390)
NDI: NDAI_0F02880(NDAI0F02880)
TPF: TPHA_0F01890(TPHA0F01890)
TBL: TBLA_0B01210(TBLA0B01210)
TDL: TDEL_0B05030(TDEL0B05030)
KAF: KAFR_0J02170(KAFR0J02170)
PIC: PICST_65227(TEP1)
CAL: CAALFM_C702650WA(TEP1)
SLB: AWJ20_1647(TEP1)
SPO: SPBC609.02(ptn1)
CNE: CNJ02580
CNB: CNBJ0880
ABP: AGABI1DRAFT123067(AGABI1DRAFT_123067)
ABV: AGABI2DRAFT187375(AGABI2DRAFT_187375)
DFA: DFA_00730 DFA_06571(pten)
EHI: EHI_197010(92.t00018)
SMIN: v1.2.038026.t1(symbB.v1.2.038026.t1)
 » show all
Reference
PMID:9072974
  Authors
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R
  Title
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
  Journal
Science 275:1943-7 (1997)
DOI:10.1126/science.275.5308.1943
  Sequence
[hsa:5728]
Reference
PMID:9593664
  Authors
Maehama T, Dixon JE
  Title
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
  Journal
J Biol Chem 273:13375-8 (1998)
DOI:10.1074/jbc.273.22.13375
  Sequence
[hsa:5728]
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