Globicephala melas (long-finned pilot whale): 115861794
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Entry
115861794 CDS
T11080
Symbol
HSD11B1
Name
(RefSeq) 11-beta-hydroxysteroid dehydrogenase 1 isoform X1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
gmf Globicephala melas (long-finned pilot whale)
Pathway
gmf00140
Steroid hormone biosynthesis
gmf00980
Metabolism of xenobiotics by cytochrome P450
gmf01100
Metabolic pathways
gmf05204
Chemical carcinogenesis - DNA adducts
Module
gmf_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:
gmf00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
115861794 (HSD11B1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
115861794 (HSD11B1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
115861794 (HSD11B1)
Enzymes [BR:
gmf01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
115861794 (HSD11B1)
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Motif
Pfam:
adh_short
adh_short_C2
KR
THF_DHG_CYH_C
DUF1776
2-Hacid_dh_C
Pyr_redox_2
NAD_binding_2
Pyr_redox_3
Shikimate_DH
Methyltransf_25
Pyr_redox
Motif
Other DBs
NCBI-GeneID:
115861794
NCBI-ProteinID:
XP_030728779
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All DBs
Position
1:38029998..38074800
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AA seq
294 aa
AA seq
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MAFMKKYLLPILGIFLAYYYYSAKEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAH
VVVTARSEEALKKVVSHCLELGASSAHYVAGTMENMTFAEQFVAKAGKLMGGLDMLILNH
ITNTNNPMTVFIDDIDHVRKSMEVNFLSYVVLSGAAMPMLKQSNGSIVVVSSIAGKTANP
LIAAYSASKFALDGFFSSIRVEYAVTNVNVSITLCILGLIDTETAMTGTAGIYNAEASPK
EECALEIIKGGALRQKEVYYDSSVLTPFLLGNPGRKIMEFLSLRNYNMEIFINN
NT seq
885 nt
NT seq
+upstream
nt +downstream
nt
atggcttttatgaagaaatatctcctccccattctggggatcttcttggcctactactac
tattctgcgaaggaggagttcagaccagagatgcttcgaggaaaaagagtgattgtcaca
ggggccagcaaggggattggaagagagatggcctatcatctggcgagaatgggagcccat
gtggtagtgacagcgaggtcagaagaagctctaaagaaggtggtatcccactgcctggag
ctcggcgcatcctccgcgcactacgttgctggcaccatggagaacatgaccttcgcagag
caatttgtggccaaagctggaaaactcatggggggactagacatgctcattctcaaccac
atcaccaacaccaacaatcctatgactgtatttatcgatgacattgaccacgtgcgcaaa
agcatggaggtcaacttcctgagttatgtggtcctgagcggggccgccatgcccatgctg
aagcagagcaacgggagcattgtggttgtctcctcgatagccgggaaaacagctaatcca
cttattgctgcctattctgcaagcaagtttgctctggatgggttcttctcctctatcagg
gtggaatatgcagtgaccaatgtcaatgtgtcgatcaccctctgtatccttggcctcata
gacacagaaacagccatgacaggaactgctgggatatacaatgcagaagcatctccaaag
gaagaatgtgccctggagatcatcaaagggggagctctgcgccaaaaggaagtatattat
gacagttcggtcttgactccgttcctgctgggaaatccagggaggaagatcatggaattt
ctctccttacgaaattataatatggaaatatttataaacaactag
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