KEGG ORTHOLOGY: K15680

ORTHOLOGY: K15680

Entry

K15680 KO

Name

HSD11B1

Definition

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

Pathway

ko00140

Steroid hormone biosynthesis

ko00980

Metabolism of xenobiotics by cytochrome P450

ko01100

Metabolic pathways

ko05204

Chemical carcinogenesis - DNA adducts

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H01111

Cortisone reductase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1

Other DBs

RN:	R02836 R03848 R04758 R04840 R09420

GO:

0070524

Genes

HSA:	3290(HSD11B1) 374875(HSD11B1L)

PTR:	455621(HSD11B1L) 457698(HSD11B1)

PPS:	100978384(HSD11B1L) 100981291(HSD11B1)

GGO:	101147766(HSD11B1)

PON:	100453076(HSD11B1) 100460111(HSD11B1L)

NLE:	100585349(HSD11B1L) 100593811(HSD11B1)

MCC:	574322(HSD11B1) 696612(HSD11B1L)

MCF:	101867467(HSD11B1) 102133758(HSD11B1L)

CSAB:

103230154(HSD11B1) 103233739(HSD11B1L)

RRO:	104664165(HSD11B1) 104665396(HSD11B1L)

RBB:	108512097(HSD11B1L) 108539553(HSD11B1)

CJC:	100396148(HSD11B1L) 100401212(HSD11B1)

SBQ:	101040472(HSD11B1)

MMU:	15483(Hsd11b1)

MCAL:

110305040(Hsd11b1)

MPAH:

110322100(Hsd11b1)

RNO:	25116(Hsd11b1)

MUN:	110553509(Hsd11b1)

CGE:	100762502(Hsd11b1)

NGI:	103727028(Hsd11b1) 103737207(Hsd11b1l)

HGL:	101716800(Hsd11b1)

CCAN:

109681612(Hsd11b1) 109688202(Hsd11b1l)

OCU:	100342395(HSD11B1) 103346788(HSD11B1L)

TUP:	102468477(HSD11B1L) 102502602(HSD11B1)

CFA:	449023(HSD11B1) 485027(HSD11B1L)

VVP:	112907163(HSD11B1) 112935555(HSD11B1L)

AML:	100466840(HSD11B1) 100468195(HSD11B1L)

UMR:	103672488(HSD11B1) 103681853(HSD11B1L)

UAH:	113262645(HSD11B1)

ORO:	101367811(HSD11B1L) 101369340(HSD11B1)

ELK:

111162366

FCA:	100529248(HSD11B1) 101092746(HSD11B1L)

PTG:	102967279(HSD11B1)

PPAD:

109255094(HSD11B1) 109255928(HSD11B1L)

AJU:	106975451(HSD11B1L) 106981789(HSD11B1)

BTA:	282589(HSD11B1) 404546(HSD11B1L)

BOM:	102270204(HSD11B1L) 102275244(HSD11B1)

BIU:	109561722(HSD11B1L) 109570467(HSD11B1)

BBUB:

102409054(HSD11B1) 102409560(HSD11B1L)

CHX:	102168375(HSD11B1) 102182297(HSD11B1L)

OAS:	101109443(HSD11B1L) 443409(HSD11B1)

SSC:	100512268(HSD11B1L) 397480(HSD11B1)

CFR:	102503994(HSD11B1)

CDK:	105091757(HSD11B1L) 105099329(HSD11B1)

BACU:

103004239(HSD11B1)

LVE:	103076014(HSD11B1L) 103086619(HSD11B1)

OOR:	101274286(HSD11B1L) 101284098(HSD11B1)

DLE:	111165962(HSD11B1L) 111184723(HSD11B1)

PCAD:

102979045(HSD11B1L) 102992666(HSD11B1)

ECB:	100056429(HSD11B1)

EPZ:	103548673(HSD11B1)

EAI:	106827175(HSD11B1) 106832397(HSD11B1L)

MYB:	102260050(HSD11B1)

MYD:	102755655(HSD11B1L) 102771648(HSD11B1)

MNA:	107532934(HSD11B1)

HAI:	109388583(HSD11B1L)

DRO:	112297497(HSD11B1) 112312415(HSD11B1L)

PALE:

102882377(HSD11B1) 102898543(HSD11B1L)

RAY:	107510916(HSD11B1L) 107517624(HSD11B1)

MJV:	108396749(HSD11B1) 108404622(HSD11B1L)

LAV:	100667019(HSD11B1)

TMU:	101355526 101361858

SHR:	100923255(HSD11B1)

PCW:	110222669(HSD11B1)

OAA:	100079059(HSD11B1) 103165340(HSD11B1L)

GGA:	408034(HSD11B1L) 419861(HSD11B1b) 771930(HSD11B1a)

MGP:	100540872(HSD11B1L) 100550364(HSD11B1) 100550517

CJO:	107324848 107324849(HSD11B1) 107325408(HSD11B1L)

NMEL:

110388207 110388337(HSD11B1) 110388940(HSD11B1L)

APLA:

101803228(HSD11B1) 101803565(HSD11B1L) 101804020

ACYG:

106041293 106041294 106049558(HSD11B1L)

TGU:	100222111 100225021

LSR:	110475377 110475385 110475766(HSD11B1L)

SCAN:

103821934(HSD11B1L) 103823273 103823329

GFR:	102037915 102038088 102042869(HSD11B1L)

FAB:	101815030 101815431 101816480(HSD11B1L)

PHI:	102101549 102103573(HSD11B1L) 102113769

PMAJ:

107214842 107214843(HSD11B1) 107215575(HSD11B1L)

CCAE:

111922428 111939805(HSD11B1) 111940332(HSD11B1L)

CCW:	104692327 104692500 104696996(HSD11B1L)

ETL:	114063124(HSD11B1) 114063139 114066353(HSD11B1L)

FPG:	101918372 101922906(HSD11B1L) 101924921

FCH:	102051959 102052853(HSD11B1L) 102053319(HSD11B1)

CLV:	102086357(HSD11B1) 102090135 102093278(HSD11B1L)

EGZ:	104124375(HSD11B1L) 104126798 104126829

NNI:	104010310 104010345 104016278(HSD11B1L)

ACUN:

113488855 113488908

PADL:

103923460(HSD11B1L) 103923566 103923602

AAM:	106486285 106490983 106490984

ASN:	102370220 102370459 102376675 102378118 102382863 102383966(HSD11B1) 102388164(HSD11B1L)

AMJ:	102560317(HSD11B1L) 102568341(HSD11B1)

PSS:	102457224(HSD11B1L) 102459148 102459410 102459465

CMY:	102936015(HSD11B1L) 102943559 102946690(HSD11B1) 102946915

CPIC:

101932631 101940528 101941697 101949610(HSD11B1L)

ACS:	100555338(hsd11b1) 100555943 100565341(hsd11b1l)

PVT:	110072366(HSD11B1) 110079276(HSD11B1L) 110081926

PBI:	103052790 103059600(HSD11B1)

PMUR:

107292272(HSD11B1) 107301624

TSR:	106539582(HSD11B1)

PMUA:

114586681 114587149 114599353(HSD11B1)

GJA:	107126071(HSD11B1) 107126084

XLA:	108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.2.S) 733357(hsd11b1l.L)

XTR:	100037875(hsd11b1l) 100038278(hsd11b1l.2) 100489345(hsd11b1)

NPR:	108789677(HSD11B1) 108791239 108800094

DRE:	100006793 100333777(hsd11b1lb) 393293(hsd11b1la)

SRX:	107719662 107729988 107750927

SANH:

107655187 107667865 107675913

SGH:	107586454 107596225

CCAR:

109094152

IPU:	108271267(hsd11b1l)

PHYP:

113534521(hsd11b1l)

AMEX:

103039071(hsd11b1l)

EEE:	113576173(hsd11b1l)

TRU:	101065468(hsd11b1l)

TNG:	GSTEN00020116G001

LCO:	104920644(hsd11b1l)

NCC:

104940951

MZE:	101486317 101486610

ONL:	100703009 100710599

OLA:	100049405(hsd11b1l)

XMA:	102223004 102233382

XCO:	114150802(hsd11b1l) 114150803

PRET:

103463669 103463670(hsd11b1l)

CVG:	107099373 107099374

NFU:	107393308 107393309(hsd11b1l)

KMR:	108230580 108230582

ALIM:

106515006 106515007

AOCE:

111578536(hsd11b1l)

CSEM:

103399936(hsd11b1l)

POV:	109625538(hsd11b1l)

LCF:	108877326(hsd11b1l)

SDU:	111232186(hsd11b1l)

SLAL:

111657468(hsd11b1l)

HCQ:	109532027(hsd11b1l)

BPEC:

110174076 110174094

MALB:

109965675

SASA:

106584264 106613760

OTW:	112250860 112266798

SALP:

111956503 111971874 111975861

ELS:	105011540(hsd11b1l) 105020762

SFM:	108919775 108921503

PKI:	111836680(hsd11b1l)

LCM:	102345616(HSD11B1) 102353052(HSD11B1L)

CMK:	103181944(hsd11b1l) 103182506(hsd11b1)

SPU:

764876

APLC:

110975185 110975957 110984537

SKO:	100373877 100374032 100374331 100374638 100374683 100374787

HRO:	HELRODRAFT_108742 HELRODRAFT_185224

LGI:	LOTGIDRAFT_138116

PCAN:

112558142

CRG:

105339932

MYI:	110457323 110463419

OBI:

106874424

LAK:	106155319 106155813 106174173 106174180 106174574 106174848 106176797 106176803 106176813 106176814 106178333 106179027

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114518992 114531929

AQU:

100631443

MBR:	MONBRDRAFT_2360

SRE:	PTSG_01197

» show all

Reference

PMID:2808402

Authors

Agarwal AK, Monder C, Eckstein B, White PC

Title

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.

Journal

J Biol Chem 264:18939-43 (1989)

Sequence

[rno:25116]

Reference

PMID:15466942

Authors

Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM

Title

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Journal

Endocr Rev 25:831-66 (2004)
DOI:10.1210/er.2003-0031

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