KEGG ORTHOLOGY: K15680

ORTHOLOGY: K15680

Entry

K15680                      KO

Symbol

HSD11B1

Name

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

Pathway

map00140

Steroid hormone biosynthesis

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

map05204

Chemical carcinogenesis - DNA adducts

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H01111

Cortisone reductase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1

Other DBs

RN:	R02836 R03848 R04758 R04840 R09420

GO:

0070524

Genes

HSA:	3290(HSD11B1) 374875(HSD11B1L)

PTR:	455621(HSD11B1L) 457698(HSD11B1)

PPS:	100978384(HSD11B1L) 100981291(HSD11B1)

GGO:	101147766(HSD11B1)

PON:	100453076(HSD11B1) 100460111(HSD11B1L)

NLE:	100585349(HSD11B1L) 100593811(HSD11B1)

MCC:	574322(HSD11B1) 696612(HSD11B1L)

MCF:	101867467(HSD11B1) 102133758(HSD11B1L)

CSAB:

103230154(HSD11B1) 103233739(HSD11B1L)

CATY:

105577073(HSD11B1) 105591834(HSD11B1L)

PANU:

101003905(HSD11B1) 101021359(HSD11B1L)

TGE:	112607892(HSD11B1) 112611828(HSD11B1L)

RRO:	104664165(HSD11B1) 104665396(HSD11B1L)

RBB:	108512097(HSD11B1L) 108539553(HSD11B1)

TFN:	117075371(HSD11B1) 117076245(HSD11B1L)

PTEH:

111521948(HSD11B1L) 111531104(HSD11B1)

CJC:	100396148(HSD11B1L) 100401212(HSD11B1)

SBQ:	101040472(HSD11B1)

CSYR:

103262372(HSD11B1)

MMUR:

105869645(HSD11B1L) 105880569(HSD11B1)

OGA:	100965741(HSD11B1L) 100966089(HSD11B1)

MMU:	15483(Hsd11b1)

MCAL:

110305040(Hsd11b1)

MPAH:

110322100(Hsd11b1)

RNO:	25116(Hsd11b1)

MCOC:

116069134(Hsd11b1)

MUN:	110553509(Hsd11b1)

CGE:	100762502(Hsd11b1)

PLEU:

114702396(Hsd11b1)

NGI:	103727028(Hsd11b1) 103737207(Hsd11b1l)

HGL:	101716800(Hsd11b1)

CPOC:

100135542(Hsd11b1)

CCAN:

109681612(Hsd11b1) 109688202(Hsd11b1l)

DORD:

105984879(Hsd11b1) 105990294(Hsd11b1l)

DSP:	122109584(Hsd11b1) 122122824(Hsd11b1l)

NCAR:

124962037 124968401

OCU:	100342395(HSD11B1) 103346788(HSD11B1L)

OPI:	101517702 101527108(HSD11B1) 101528507(HSD11B1L)

TUP:	102468477(HSD11B1L) 102502602(HSD11B1)

CFA:	449023(HSD11B1) 485027(HSD11B1L)

VVP:	112907163(HSD11B1) 112935555(HSD11B1L)

VLG:	121492647(HSD11B1) 121495784(HSD11B1L)

AML:	100466840(HSD11B1) 100468195(HSD11B1L)

UMR:	103672488(HSD11B1) 103681853(HSD11B1L)

UAH:	113262645(HSD11B1)

UAR:	123779007(HSD11B1L) 123785812(HSD11B1)

ELK:

111162366

LLV:	125085935 125088367

MPUF:

101675282(HSD11B1L) 101691949(HSD11B1)

ORO:	101367811(HSD11B1L) 101369340(HSD11B1)

EJU:	114225960(HSD11B1) 114226334(HSD11B1L)

ZCA:	113918784(HSD11B1L) 113933565(HSD11B1)

MLX:	118005226(HSD11B1L) 118014284(HSD11B1)

FCA:	100529248(HSD11B1) 101092746(HSD11B1L)

PYU:	121011723(HSD11B1) 121021338(HSD11B1L)

PBG:	122476530(HSD11B1) 122486763(HSD11B1L)

PTG:	102967279(HSD11B1)

PPAD:

109255094(HSD11B1) 109255928(HSD11B1L)

AJU:	106975451(HSD11B1L) 106981789(HSD11B1)

HHV:	120230497(HSD11B1) 120242094(HSD11B1L)

BTA:	282589(HSD11B1) 404546(HSD11B1L)

BOM:	102270204(HSD11B1L) 102275244(HSD11B1)

BIU:	109561722(HSD11B1L) 109570467(HSD11B1)

BBUB:

102409054(HSD11B1) 102409560(HSD11B1L)

CHX:	102168375(HSD11B1) 102182297(HSD11B1L)

OAS:	101109443(HSD11B1L) 443409(HSD11B1)

ODA:	120864858(HSD11B1L) 120880020(HSD11B1)

CCAD:

122440271(HSD11B1L) 122452316 122452545

SSC:	100512268(HSD11B1L) 397480(HSD11B1)

CFR:	102503994(HSD11B1)

CBAI:

105064506(HSD11B1) 105078239(HSD11B1L)

CDK:	105091757(HSD11B1L) 105099329(HSD11B1)

VPC:	102532692(HSD11B1L) 102546120(HSD11B1)

BACU:

103004239(HSD11B1) 103006723(HSD11B1L)

LVE:	103076014(HSD11B1L) 103086619(HSD11B1)

OOR:	101274286(HSD11B1L) 101284098(HSD11B1)

DLE:	111165962(HSD11B1L) 111184723(HSD11B1)

PCAD:

102979045(HSD11B1L) 102992666(HSD11B1)

PSIU:

116744231(HSD11B1) 116750482(HSD11B1L)

ECB:	100056429(HSD11B1)

EPZ:	103548673(HSD11B1)

EAI:	106827175(HSD11B1) 106832397(HSD11B1L)

MYB:	102260050(HSD11B1)

MYD:	102755655(HSD11B1L) 102771648(HSD11B1)

MMYO:

118658804(HSD11B1L) 118673043(HSD11B1)

MLF:	102419340(HSD11B1L) 102439972(HSD11B1)

MNA:	107532934(HSD11B1)

PKL:	118721335(HSD11B1) 118731439(HSD11B1L)

HAI:	109388583(HSD11B1L)

DRO:	112297497(HSD11B1) 112312415(HSD11B1L)

SHON:

118974202(HSD11B1) 118984541(HSD11B1L)

AJM:	119043084(HSD11B1) 119063755(HSD11B1L)

PDIC:

114503624(HSD11B1L) 114511869(HSD11B1)

PHAS:

123813655(HSD11B1L) 123818427(HSD11B1)

MMF:	118637041(HSD11B1) 118644010(HSD11B1L)

RFQ:	117015114(HSD11B1) 117037629(HSD11B1L)

PALE:

102882377(HSD11B1) 102898543(HSD11B1L)

PGIG:

120608487(HSD11B1) 120615419(HSD11B1L)

PVP:	105300302(HSD11B1) 105301066(HSD11B1L)

RAY:	107510916(HSD11B1L) 107517624(HSD11B1)

MJV:	108396749(HSD11B1) 108404622(HSD11B1L)

TOD:	119233923(HSD11B1) 119240609(HSD11B1L)

SARA:

101550878(HSD11B1)

LAV:	100667019(HSD11B1)

TMU:	101355526 101361858

DNM:	101438259 101441646(HSD11B1L)

SHR:	100923255(HSD11B1)

PCW:	110222669(HSD11B1)

OAA:	100079059(HSD11B1) 103165340(HSD11B1L)

GGA:	408034(HSD11B1L) 419861(HSD11B1b) 771930(HSD11B1a)

PCOC:

116236143(HSD11B1L) 116237020 116237050(HSD11B1)

MGP:	100540872(HSD11B1L) 100550364(HSD11B1) 100550517

CJO:	107324848 107324849(HSD11B1) 107325408(HSD11B1L)

NMEL:

110388207 110388337(HSD11B1) 110388940(HSD11B1L)

APLA:

101803228(HSD11B1) 101803565(HSD11B1L) 101804020

ACYG:

106041293 106041294 106049558(HSD11B1L)

AFUL:

116498658 116498834(HSD11B1) 116499039(HSD11B1L)

TGU:	100222111 100225021

LSR:	110475377 110475385 110475766(HSD11B1L)

SCAN:

103821934(HSD11B1L) 103823273 103823329

PMOA:

120495938 120495939 120498067(HSD11B1L)

OTC:	121342426(HSD11B1L) 121347985 121347986

PRUF:

121353601 121353609 121361273(HSD11B1L)

GFR:	102037915 102038088 102042869(HSD11B1L)

FAB:	101815030 101815431 101816480(HSD11B1L)

PHI:	102101549 102103573(HSD11B1L) 102113769

PMAJ:

107214842 107214843(HSD11B1) 107215575(HSD11B1L)

CCAE:

111922428 111939805(HSD11B1) 111940332(HSD11B1L)

CCW:	104692327 104692500 104696996(HSD11B1L)

ETL:	114063124(HSD11B1) 114063139 114066353(HSD11B1L)

ZAB:	102061343 102061510 102071375

FPG:	101918372 101922906(HSD11B1L) 101924921

FCH:	102051959 102052853(HSD11B1L) 102053319(HSD11B1)

CLV:	102086357(HSD11B1) 102090135 102093278(HSD11B1L)

EGZ:	104124375(HSD11B1L) 104126798 104126829

NNI:	104010310 104010345 104016278(HSD11B1L)

ACUN:

113488855 113488908

TALA:

104365605 104367640

PADL:

103923460(HSD11B1L) 103923566 103923602

ACHC:

115335436 115335441 115348809(HSD11B1L)

AAM:	106486285 106490983 106490984

AROW:

112970600 112971588 112971589

NPD:	112944666(HSD11B1) 112946019 112946809(HSD11B1L)

DNE:	112988079(HSD11B1L) 112990180 112990181 112994593

ASN:	102370220 102370459 102376675 102378118 102382863 102383966(HSD11B1) 102388164(HSD11B1L)

AMJ:	102560317(HSD11B1L) 102568341(HSD11B1)

CPOO:

109317894 109317896 109320531

GGN:	109290341 109290342 109295284 109295285(HSD11B1)

PSS:	102457224(HSD11B1L) 102459148 102459410 102459465

CMY:	102936015(HSD11B1L) 102943559 102946690 102946915

CPIC:

101932631 101940528 101941697 101949610(HSD11B1L)

TST:	117868879(HSD11B1L) 117877446(HSD11B1) 117877448 117888056

CABI:

116823700(HSD11B1L) 116829054 116832983 116832984(HSD11B1)

MRV:	120385954 120391579(HSD11B1L) 120403612(HSD11B1) 120403613

ACS:	100555338(hsd11b1) 100555943 100565341(hsd11b1l)

PVT:	110072366(HSD11B1) 110079276(HSD11B1L) 110081926

SUND:

121916428 121929832(HSD11B1) 121936828(HSD11B1L)

PBI:	103052790 103059600(HSD11B1)

PMUR:

107292272(HSD11B1) 107301624

TSR:	106539582(HSD11B1)

PGUT:

117663835(HSD11B1) 117677900

VKO:	123016880(HSD11B1L) 123030429 123031762(HSD11B1) 123035532

PMUA:

114586681 114587149 114599353(HSD11B1)

ZVI:	118076515 118088704(HSD11B1)

GJA:	107126071(HSD11B1) 107126084

XLA:	108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.2.S) 733357(hsd11b1l.L)

XTR:	100037875(hsd11b1l) 100038278(hsd11b1l.2) 100489345(hsd11b1)

NPR:	108789677(HSD11B1) 108791239 108800094

RTEM:

120909884(HSD11B1L) 120927082(HSD11B1) 120937278

BBUF:

120989408(HSD11B1L) 120991433 120993325(HSD11B1)

BGAR:

122927338 122927370 122932560(HSD11B1) 122934148

DRE:	100006793 100333777(hsd11b1lb) 393293(hsd11b1la)

SRX:	107719662 107729988 107750927

SANH:

107655187 107667865 107675913

SGH:	107586454 107596225

CCAR:

109094152

CAUA:

113040078 113064605 113072750 113112629

PPRM:

120491917(hsd11b1lb) 120495285(hsd11b1la)

IPU:	108271267(hsd11b1la)

PHYP:

113534521(hsd11b1l)

SMEO:

124390749(hsd11b1la)

TFD:	113657672(hsd11b1la)

AMEX:

103039071(hsd11b1l)

EEE:	113576173(hsd11b1l)

TRU:	101065468(hsd11b1l)

TNG:	GSTEN00020116G001

LCO:	104920644(hsd11b1l)

NCC:

104940951

CGOB:

115007217(hsd11b1l)

ELY:	117254274(hsd11b1la)

PLEP:

121941308(hsd11b1la)

SLUC:

116063294(hsd11b1la)

ECRA:

117950233(hsd11b1la)

PFLV:

114562060(hsd11b1l)

GAT:	120823458(hsd11b1la)

PPUG:

119217151(hsd11b1la)

MSAM:

119900899(hsd11b1la)

CUD:	121512434(hsd11b1la)

MZE:	101486317 101486610

ONL:	100703009 100710599

OAU:	116310027 116310062

OLA:	100049405(hsd11b1l)

OML:	112140958 112140963

XMA:	102223004 102233382

XCO:	114150802(hsd11b1l) 114150803

XHE:	116725470 116725471

PRET:

103463669 103463670(hsd11b1l)

PFOR:

103149837 103149838 103149839

PLAI:

106934967 106940983 106944392

PMEI:

106924193 106924194(hsd11b1l)

GAF:	122839011(hsd11b1la)

CVG:	107099373 107099374

CTUL:

119780686 119792540 119792545

GMU:	124873984 124873985

NFU:	107393308 107393309(hsd11b1l)

KMR:	108230580 108230582

ALIM:

106515006 106515007

NWH:	119407454(hsd11b1la) 119430717

AOCE:

111578536(hsd11b1l)

CSEM:

103399936(hsd11b1l)

POV:	109625538(hsd11b1l)

SSEN:

122780383 122780384

HHIP:

117760653(hsd11b1la)

LCF:	108877326(hsd11b1l)

SDU:	111232186(hsd11b1l)

SLAL:

111657468(hsd11b1l)

XGL:	120790442(hsd11b1la)

HCQ:	109532027(hsd11b1l)

BPEC:

110174076 110174094

MALB:

109965675

SASA:

106584264 106613760

OTW:	112250860 112266798

OMY:	110521423 110524276

OGO:	123997586 124009433 124037039

ONE:	115101538 115107391 115145448

SALP:

111956503 111971874 111975861

SNH:	120051791 120055190 120055610(hsd11b1lb)

ELS:	105011540(hsd11b1l) 105020762

SFM:	108919775 108921503

PKI:	111836680(hsd11b1l)

AANG:

118229426

LOC:	102687863(hsd11b1l)

PSPA:

121300663 121309572

ARUT:

117401354 117428859

LCM:	102345616(HSD11B1) 102353052(HSD11B1L)

CMK:	103181944(hsd11b1la) 103182506

BBEL:

109464062 109465082 109466479 109466504 109466505 109468621 109468653 109468666 109470987 109472762 109472763 109472764 109487853

SCLV:

120346036

SPU:

764876

APLC:

110975185 110975957 110984537

SKO:	100373877 100374032 100374331 100374638 100374683 100374787

HRO:	HELRODRAFT_108742 HELRODRAFT_185224

LGI:	LOTGIDRAFT_138116

PCAN:

112558142

BGT:

106076379

GAE:

121372891

HRF:	124116686 124116687

HRJ:

124279069

CRG:

105339932

MYI:	110457323 110463419

PMAX:

117315760 117339350 117339762

MMER:

123540221 123543158 123555597

OBI:

106874424

OSN:

115216330

LAK:	106155319 106155813 106174173 106174180 106174574 106174848 106176797 106176803 106176813 106176814 106178333 106179027

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114518992 114531929

XEN:

124439657

AQU:

100631443

TDC:

119359480

MBR:	MONBRDRAFT_2360

SRE:	PTSG_01197

» show all

Reference

PMID:2808402

Authors

Agarwal AK, Monder C, Eckstein B, White PC

Title

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.

Journal

J Biol Chem 264:18939-43 (1989)

Sequence

[rno:25116]

Reference

PMID:15466942

Authors

Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM

Title

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Journal

Endocr Rev 25:831-66 (2004)
DOI:10.1210/er.2003-0031

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