KEGG   Globicephala melas (long-finned pilot whale): 115865036
Entry
115865036         CDS       T11080                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
gmf  Globicephala melas (long-finned pilot whale)
Pathway
gmf01521  EGFR tyrosine kinase inhibitor resistance
gmf01522  Endocrine resistance
gmf04010  MAPK signaling pathway
gmf04012  ErbB signaling pathway
gmf04014  Ras signaling pathway
gmf04015  Rap1 signaling pathway
gmf04022  cGMP-PKG signaling pathway
gmf04024  cAMP signaling pathway
gmf04066  HIF-1 signaling pathway
gmf04068  FoxO signaling pathway
gmf04071  Sphingolipid signaling pathway
gmf04072  Phospholipase D signaling pathway
gmf04140  Autophagy - animal
gmf04148  Efferocytosis
gmf04150  mTOR signaling pathway
gmf04151  PI3K-Akt signaling pathway
gmf04210  Apoptosis
gmf04218  Cellular senescence
gmf04270  Vascular smooth muscle contraction
gmf04370  VEGF signaling pathway
gmf04371  Apelin signaling pathway
gmf04517  IgSF CAM signaling
gmf04540  Gap junction
gmf04550  Signaling pathways regulating pluripotency of stem cells
gmf04613  Neutrophil extracellular trap formation
gmf04620  Toll-like receptor signaling pathway
gmf04650  Natural killer cell mediated cytotoxicity
gmf04660  T cell receptor signaling pathway
gmf04662  B cell receptor signaling pathway
gmf04664  Fc epsilon RI signaling pathway
gmf04720  Long-term potentiation
gmf04722  Neurotrophin signaling pathway
gmf04730  Long-term depression
gmf04810  Regulation of actin cytoskeleton
gmf04910  Insulin signaling pathway
gmf04912  GnRH signaling pathway
gmf04915  Estrogen signaling pathway
gmf04916  Melanogenesis
gmf04917  Prolactin signaling pathway
gmf04919  Thyroid hormone signaling pathway
gmf04921  Oxytocin signaling pathway
gmf04926  Relaxin signaling pathway
gmf04929  GnRH secretion
gmf04934  Cushing syndrome
gmf04935  Growth hormone synthesis, secretion and action
gmf05010  Alzheimer disease
gmf05022  Pathways of neurodegeneration - multiple diseases
gmf05132  Salmonella infection
gmf05135  Yersinia infection
gmf05160  Hepatitis C
gmf05161  Hepatitis B
gmf05163  Human cytomegalovirus infection
gmf05164  Influenza A
gmf05165  Human papillomavirus infection
gmf05166  Human T-cell leukemia virus 1 infection
gmf05167  Kaposi sarcoma-associated herpesvirus infection
gmf05170  Human immunodeficiency virus 1 infection
gmf05200  Pathways in cancer
gmf05205  Proteoglycans in cancer
gmf05206  MicroRNAs in cancer
gmf05207  Chemical carcinogenesis - receptor activation
gmf05208  Chemical carcinogenesis - reactive oxygen species
gmf05210  Colorectal cancer
gmf05211  Renal cell carcinoma
gmf05213  Endometrial cancer
gmf05214  Glioma
gmf05215  Prostate cancer
gmf05216  Thyroid cancer
gmf05218  Melanoma
gmf05219  Bladder cancer
gmf05220  Chronic myeloid leukemia
gmf05221  Acute myeloid leukemia
gmf05223  Non-small cell lung cancer
gmf05224  Breast cancer
gmf05225  Hepatocellular carcinoma
gmf05226  Gastric cancer
gmf05230  Central carbon metabolism in cancer
gmf05231  Choline metabolism in cancer
gmf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:gmf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    115865036 (MAP2K2)
   04012 ErbB signaling pathway
    115865036 (MAP2K2)
   04014 Ras signaling pathway
    115865036 (MAP2K2)
   04015 Rap1 signaling pathway
    115865036 (MAP2K2)
   04370 VEGF signaling pathway
    115865036 (MAP2K2)
   04371 Apelin signaling pathway
    115865036 (MAP2K2)
   04066 HIF-1 signaling pathway
    115865036 (MAP2K2)
   04068 FoxO signaling pathway
    115865036 (MAP2K2)
   04072 Phospholipase D signaling pathway
    115865036 (MAP2K2)
   04071 Sphingolipid signaling pathway
    115865036 (MAP2K2)
   04024 cAMP signaling pathway
    115865036 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    115865036 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    115865036 (MAP2K2)
   04150 mTOR signaling pathway
    115865036 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    115865036 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    115865036 (MAP2K2)
   04148 Efferocytosis
    115865036 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    115865036 (MAP2K2)
   04218 Cellular senescence
    115865036 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    115865036 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    115865036 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    115865036 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    115865036 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    115865036 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    115865036 (MAP2K2)
   04660 T cell receptor signaling pathway
    115865036 (MAP2K2)
   04662 B cell receptor signaling pathway
    115865036 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    115865036 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    115865036 (MAP2K2)
   04929 GnRH secretion
    115865036 (MAP2K2)
   04912 GnRH signaling pathway
    115865036 (MAP2K2)
   04915 Estrogen signaling pathway
    115865036 (MAP2K2)
   04917 Prolactin signaling pathway
    115865036 (MAP2K2)
   04921 Oxytocin signaling pathway
    115865036 (MAP2K2)
   04926 Relaxin signaling pathway
    115865036 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    115865036 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    115865036 (MAP2K2)
   04916 Melanogenesis
    115865036 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    115865036 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    115865036 (MAP2K2)
   04730 Long-term depression
    115865036 (MAP2K2)
   04722 Neurotrophin signaling pathway
    115865036 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    115865036 (MAP2K2)
   05206 MicroRNAs in cancer
    115865036 (MAP2K2)
   05205 Proteoglycans in cancer
    115865036 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    115865036 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    115865036 (MAP2K2)
   05230 Central carbon metabolism in cancer
    115865036 (MAP2K2)
   05231 Choline metabolism in cancer
    115865036 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    115865036 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    115865036 (MAP2K2)
   05225 Hepatocellular carcinoma
    115865036 (MAP2K2)
   05226 Gastric cancer
    115865036 (MAP2K2)
   05214 Glioma
    115865036 (MAP2K2)
   05216 Thyroid cancer
    115865036 (MAP2K2)
   05221 Acute myeloid leukemia
    115865036 (MAP2K2)
   05220 Chronic myeloid leukemia
    115865036 (MAP2K2)
   05218 Melanoma
    115865036 (MAP2K2)
   05211 Renal cell carcinoma
    115865036 (MAP2K2)
   05219 Bladder cancer
    115865036 (MAP2K2)
   05215 Prostate cancer
    115865036 (MAP2K2)
   05213 Endometrial cancer
    115865036 (MAP2K2)
   05224 Breast cancer
    115865036 (MAP2K2)
   05223 Non-small cell lung cancer
    115865036 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    115865036 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    115865036 (MAP2K2)
   05161 Hepatitis B
    115865036 (MAP2K2)
   05160 Hepatitis C
    115865036 (MAP2K2)
   05164 Influenza A
    115865036 (MAP2K2)
   05163 Human cytomegalovirus infection
    115865036 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    115865036 (MAP2K2)
   05165 Human papillomavirus infection
    115865036 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    115865036 (MAP2K2)
   05135 Yersinia infection
    115865036 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    115865036 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    115865036 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    115865036 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    115865036 (MAP2K2)
   01522 Endocrine resistance
    115865036 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gmf01001]
    115865036 (MAP2K2)
Enzymes [BR:gmf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     115865036 (MAP2K2)
Protein kinases [BR:gmf01001]
 Serine/threonine kinases: STE group
  STE7 family
   115865036 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 115865036
NCBI-ProteinID: XP_030735155
LinkDB
Position
3:168156393..168180761
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGIFTQDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctgcagaagaag
ctagaggagctagaacttgacgagcagcagaagaagcggctggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaaaggatctcggagctgggagcc
gggaacggtggggtggtcaccaaggtccagcacagaccctcgggcctcatcatggcaaga
aagctgatccacctggagatcaagccagccatccggaaccagatcatccgtgagctgcag
gtgctgcatgagtgtaactctccgtacatcgtgggcttctatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggtggctccctggaccaggtgttgaaa
gaagccaagaggatccccgaagagatcctggggaaggtcagcatcgcggttctgcggggc
ctggcgtatctccgggagaagcaccagatcatgcaccgagatgtgaagccatccaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgactttggggtgagcgggcagctcatc
gactccatggccaactccttcgtgggcacgcggtcctacatgtctccggagcggctgcaa
ggcactcactactcggtgcagtcagacatctggagcatgggcctgtccctggtggagctg
tccattggaaggtaccccatccccccgccggacgccaaggagctggaggccatatttggc
cggcccatggtcgacggcgcggaaggagagcctcacagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcatgggatggacagccggccggccatggcaatctttgag
ctgctggactacatcgtgaacgagcctcctcccaagctgcccaacggcatcttcacccag
gacttccaggagttcgtaaataaatgcctaattaagaacccagcagagcgagcagatctg
aagatgctcatgaaccacgccttcatcaagcggtctgaggtggaagaagtggattttgcc
ggctggttgtgtaaaacgctgcggctgaaccagcccagcacgcccacgcgcactgccgtc
tga

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