KEGG   Galeopterus variegatus (Sunda flying lemur): 103606318
Entry
103606318         CDS       T08727                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
gvr  Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr00562  Inositol phosphate metabolism
gvr01100  Metabolic pathways
gvr01521  EGFR tyrosine kinase inhibitor resistance
gvr04012  ErbB signaling pathway
gvr04014  Ras signaling pathway
gvr04015  Rap1 signaling pathway
gvr04020  Calcium signaling pathway
gvr04062  Chemokine signaling pathway
gvr04064  NF-kappa B signaling pathway
gvr04066  HIF-1 signaling pathway
gvr04070  Phosphatidylinositol signaling system
gvr04072  Phospholipase D signaling pathway
gvr04360  Axon guidance
gvr04370  VEGF signaling pathway
gvr04613  Neutrophil extracellular trap formation
gvr04650  Natural killer cell mediated cytotoxicity
gvr04658  Th1 and Th2 cell differentiation
gvr04659  Th17 cell differentiation
gvr04660  T cell receptor signaling pathway
gvr04664  Fc epsilon RI signaling pathway
gvr04666  Fc gamma R-mediated phagocytosis
gvr04670  Leukocyte transendothelial migration
gvr04722  Neurotrophin signaling pathway
gvr04750  Inflammatory mediator regulation of TRP channels
gvr04919  Thyroid hormone signaling pathway
gvr04933  AGE-RAGE signaling pathway in diabetic complications
gvr04935  Growth hormone synthesis, secretion and action
gvr05012  Parkinson disease
gvr05022  Pathways of neurodegeneration - multiple diseases
gvr05135  Yersinia infection
gvr05167  Kaposi sarcoma-associated herpesvirus infection
gvr05170  Human immunodeficiency virus 1 infection
gvr05171  Coronavirus disease - COVID-19
gvr05200  Pathways in cancer
gvr05205  Proteoglycans in cancer
gvr05206  MicroRNAs in cancer
gvr05214  Glioma
gvr05223  Non-small cell lung cancer
gvr05225  Hepatocellular carcinoma
gvr05231  Choline metabolism in cancer
gvr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
gvr05417  Lipid and atherosclerosis
Module
gvr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:gvr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103606318 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103606318 (PLCG1)
   04014 Ras signaling pathway
    103606318 (PLCG1)
   04015 Rap1 signaling pathway
    103606318 (PLCG1)
   04370 VEGF signaling pathway
    103606318 (PLCG1)
   04064 NF-kappa B signaling pathway
    103606318 (PLCG1)
   04066 HIF-1 signaling pathway
    103606318 (PLCG1)
   04020 Calcium signaling pathway
    103606318 (PLCG1)
   04070 Phosphatidylinositol signaling system
    103606318 (PLCG1)
   04072 Phospholipase D signaling pathway
    103606318 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103606318 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    103606318 (PLCG1)
   04660 T cell receptor signaling pathway
    103606318 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    103606318 (PLCG1)
   04659 Th17 cell differentiation
    103606318 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    103606318 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    103606318 (PLCG1)
   04670 Leukocyte transendothelial migration
    103606318 (PLCG1)
   04062 Chemokine signaling pathway
    103606318 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103606318 (PLCG1)
   04919 Thyroid hormone signaling pathway
    103606318 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103606318 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103606318 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    103606318 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103606318 (PLCG1)
   05206 MicroRNAs in cancer
    103606318 (PLCG1)
   05205 Proteoglycans in cancer
    103606318 (PLCG1)
   05231 Choline metabolism in cancer
    103606318 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103606318 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103606318 (PLCG1)
   05214 Glioma
    103606318 (PLCG1)
   05223 Non-small cell lung cancer
    103606318 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103606318 (PLCG1)
   05171 Coronavirus disease - COVID-19
    103606318 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103606318 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103606318 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    103606318 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    103606318 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103606318 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103606318 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103606318 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:gvr04131]
    103606318 (PLCG1)
Enzymes [BR:gvr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103606318 (PLCG1)
Membrane trafficking [BR:gvr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103606318 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103606318 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 103606318
NCBI-ProteinID: XP_008589158
LinkDB
Position
Unknown
AA seq 1257 aa
MTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQ
EDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIE
RWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA
QLYRSLMYSAQKTMDLPFLEASALRAGERPELCRVSLPEFQQFLLEYQGELWAVDQLQVQ
DFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSIWNSHLDGVCPDSMNNPLSHYWISSS
HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVL
HTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDITADGLPSPNQ
LKRKILIKHKKLAEGSAYEEVPMSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTS
SKIYYSEETSSDQGNEDEEEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCI
ETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYD
LITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVR
KRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRY
PINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTK
SAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVSPVALEPEREHLDENSPLGDLLRG
VVDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTAD
ARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNK
AKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALF
MTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEI
EVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNAEFAFLRFVVYEEDMFSDQNFLA
QATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKQENGDLSPFSGTSLRERGS
DASGQLFHGRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3774 nt   +upstreamnt  +downstreamnt
atgactttgttctactccaagaagtcgcagcggcccgagcggaagaccttccaggtcaag
ctggagacgcgccagatcacatggagccgcggcgccgacaagatcgagggggccattgat
attcgtgaaatcaaggaaatccgtccagggaagacctcgagggactttgatcgctatcaa
gaggaccctgctttccggcccgaccaatcacactgctttgtcatcctctatggaatggaa
ttccgcttgaagaccctgagcctgcaagccacgtctgaggatgaagtgaacatgtggatc
aagggcttaacctggctgatggaggatacattgcaggcagccacacctctgcagattgag
aggtggcttcggaagcaattctactcagtggatcggaatcgtgaggatcgtatatcagcc
aaggacctgaagaacatgctgtcccaggtcaactaccgggtccccaatatgcgtttcctc
cgagagcggctgacagacctggagcagcgcagcggggacatcacctatgggcagtttgct
cagctgtaccgcagcctcatgtacagcgctcagaagacgatggaccttcccttcttggaa
gccagtgctctgagggctggggagcggccggagctctgccgagtgtcccttcctgagttc
cagcagttccttcttgagtaccagggggagctgtgggctgtggaccagctccaggtgcag
gacttcatgctcagcttcctccgagaccccttgcgagagatcgaggagccatacttcttc
ctggatgagtttgtcaccttcctgttctccaaagagaacagcatatggaactcccatctg
gatggggtgtgcccggactccatgaacaaccctctctcccattactggatctcctcctcg
cacaacacgtatctgacaggggaccagttctccagtgagtcctccctggaagcctacgct
cgctgcctgcggatgggctgtcgctgcattgagttggattgctgggacggcccagatggg
atgccagttatttaccacggacacaccctcaccaccaagatcaagttctcagacgtcctg
cacaccatcaaggagcatgcctttgtggcctcagagtacccagtcatcctgtccatcgag
gaccactgcagcattgcccagcagaggaacatggcccagtacttcaagaaggtacttggg
gacacgctcctcaccaagcctgtggacatcactgctgatgggctcccctcacccaaccag
ctcaagaggaagatcctcatcaagcacaagaagctggcagagggcagtgcctatgaggag
gtgcccatgtctgtgatgtactcagagaacgacatcagcaactccatcaagaacggcatc
ctctacctggaggaccctgtgaaccacgaatggtatccccactactttgtcctgaccagc
agtaagatttattactctgaggagaccagcagtgaccagggcaacgaagatgaggaggag
cccaaggaggccagtggcagcacagagctgcactccaatgagaagtggttccacgggaag
ctgggcgcggggcgcgatgggcggcacattgccgagcgcctgctcactgagtactgcatt
gagaccggggcccctgacggctccttccttgtgcgagagagcgagaccttcgtgggtgac
tacacgctgtctttctggcggaatgggaaggtccagcactgccgtatccactcccggcag
gatgctgggacccccaagttcttcttgacagacaacctcgtctttgattccctgtacgac
ctcatcacacactaccagcaggtgcccctccgctgcaacgagtttgagatgcgcctctca
gagcctgtcccacagaccaatgcccacgagagcaaagagtggtaccatgcgagtctgacc
agagcacaggctgagcacatgctaatgcgtgtccccagagatggggccttcctggtgcgg
aaacggaatgagcccaactcatacgccatctccttccgagctgagggcaagatcaagcat
tgccgtgtgcagcaggagggccagaccgtgatgctggggaactcggagtttgacagtctt
gtcgaccttatcagctactatgagaagcacccgctgtaccgcaagatgaagctgcgctat
cccatcaatgaggaggcgctggagaagattggcacagctgagccagactacggggcccta
tatgagggacgcaaccccggcttctatgtggaggcaaaccctatgccgactttcaagtgt
gcagtcaaagccctctttgactacaaggcccagagagaggacgagctgacctttactaag
agcgccatcatccagaacgtggagaagcaagagggaggctggtggcgaggggactatggt
gggaagaagcagctgtggttcccgtcaaactacgtggaagagatggtcagcccggtggcc
ctggagcctgagagggagcacttggacgagaacagcccgctgggggacttgctgcggggg
gttgtggatgtgccggcttgtcagattgccatccgacctgagggcaagaacaaccggctc
ttcgtcttctccatcagcatggcctcagtggcccactggtcccttgatgttgccgctgac
tcacaggaggagctgcaggactgggtgaaaaagatccgagaagtggcccagactgcagat
gccaggctcactgaggggaagatgatggaacggaggaagaagattgctctggagctctct
gagcttgtcgtctactgccggcctgttcccttcgatgaagagaagattggcacagaacgt
gcctgctaccgggacatgtcatccttcccggaaaccaaggctgagaaatatgtgaacaag
gccaaaggcaagaagttcctccagtacaatcggctgcagctctcccgcatctaccccaag
ggccagcggctggactcctccaactatgatcctttgcccatgtggatctgtggcagccag
cttgtggccctcaacttccagaccccagacaagccgatgcagatgaaccaagcccttttc
atgactggcaggcactgtggctatgtgctgcagccaagcaccatgcgggatgaggccttc
gacccctttgacaagagcagcctccgcgggctggagccctgtgctatctgcatcgaggtg
ctgggggcccggcatctgccaaagaatggccgaggcattgtgtgtccttttgtggagatt
gaggtggctggagctgagtatgacagcaccaagcagaagacagagtttgtagtggacaat
ggactgaaccccgtgtggccagccaagccgttccacttccagatcagtaacgctgaattt
gccttcctgcgctttgtggtatatgaggaagacatgtttagtgaccagaacttcttggct
caggctactttcccagtaaaaggcctgaagacaggatacagagcagtgcctttgaagaac
aactatagcgaggacctggagctggcctccctgcttatcaagatcgacattttcccagca
aagcaggagaatggtgacctcagtcccttcagtggtacgtccctgcgggagcggggctca
gatgcctcaggccagctatttcatggccgggcccgggaaggctcctttgaggcccgctac
cagcagccatttgaggacttccgcatttcccaggagcatctggcagaccattttgacagt
cgggaacgaagggccccaagaaggactcgggtcaatggagacaaccgcctctag

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