Heterocephalus glaber (naked mole-rat): 101698293 Help Entry 101698293         CDS       T02812                                  Symbol Adcy8 Name (RefSeq) adenylate cyclase 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00230   Purine metabolism hgl01100   Metabolic pathways hgl01522   Endocrine resistance hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04024   cAMP signaling pathway hgl04062   Chemokine signaling pathway hgl04072   Phospholipase D signaling pathway hgl04081   Hormone signaling hgl04082   Neuroactive ligand signaling hgl04114   Oocyte meiosis hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04611   Platelet activation hgl04713   Circadian entrainment hgl04714   Thermogenesis hgl04720   Long-term potentiation hgl04723   Retrograde endocannabinoid signaling hgl04724   Glutamatergic synapse hgl04725   Cholinergic synapse hgl04727   GABAergic synapse hgl04742   Taste transduction hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04913   Ovarian steroidogenesis hgl04914   Progesterone-mediated oocyte maturation hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04921   Oxytocin signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04976   Bile secretion hgl05032   Morphine addiction hgl05163   Human cytomegalovirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101698293 (Adcy8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101698293 (Adcy8)    04371 Apelin signaling pathway     101698293 (Adcy8)    04020 Calcium signaling pathway     101698293 (Adcy8)    04072 Phospholipase D signaling pathway     101698293 (Adcy8)    04024 cAMP signaling pathway     101698293 (Adcy8)    04022 cGMP-PKG signaling pathway     101698293 (Adcy8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101698293 (Adcy8)    04081 Hormone signaling     101698293 (Adcy8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101698293 (Adcy8)   09144 Cellular community - eukaryotes    04540 Gap junction     101698293 (Adcy8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101698293 (Adcy8)    04062 Chemokine signaling pathway     101698293 (Adcy8)   09152 Endocrine system    04911 Insulin secretion     101698293 (Adcy8)    04923 Regulation of lipolysis in adipocytes     101698293 (Adcy8)    04912 GnRH signaling pathway     101698293 (Adcy8)    04913 Ovarian steroidogenesis     101698293 (Adcy8)    04915 Estrogen signaling pathway     101698293 (Adcy8)    04914 Progesterone-mediated oocyte maturation     101698293 (Adcy8)    04921 Oxytocin signaling pathway     101698293 (Adcy8)    04926 Relaxin signaling pathway     101698293 (Adcy8)    04935 Growth hormone synthesis, secretion and action     101698293 (Adcy8)    04918 Thyroid hormone synthesis     101698293 (Adcy8)    04928 Parathyroid hormone synthesis, secretion and action     101698293 (Adcy8)    04916 Melanogenesis     101698293 (Adcy8)    04925 Aldosterone synthesis and secretion     101698293 (Adcy8)    04927 Cortisol synthesis and secretion     101698293 (Adcy8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101698293 (Adcy8)    04270 Vascular smooth muscle contraction     101698293 (Adcy8)   09154 Digestive system    04970 Salivary secretion     101698293 (Adcy8)    04971 Gastric acid secretion     101698293 (Adcy8)    04972 Pancreatic secretion     101698293 (Adcy8)    04976 Bile secretion     101698293 (Adcy8)   09156 Nervous system    04724 Glutamatergic synapse     101698293 (Adcy8)    04727 GABAergic synapse     101698293 (Adcy8)    04725 Cholinergic synapse     101698293 (Adcy8)    04720 Long-term potentiation     101698293 (Adcy8)    04723 Retrograde endocannabinoid signaling     101698293 (Adcy8)   09157 Sensory system    04742 Taste transduction     101698293 (Adcy8)    04750 Inflammatory mediator regulation of TRP channels     101698293 (Adcy8)   09149 Aging    04211 Longevity regulating pathway     101698293 (Adcy8)    04213 Longevity regulating pathway - multiple species     101698293 (Adcy8)   09159 Environmental adaptation    04713 Circadian entrainment     101698293 (Adcy8)    04714 Thermogenesis     101698293 (Adcy8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101698293 (Adcy8)    05207 Chemical carcinogenesis - receptor activation     101698293 (Adcy8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101698293 (Adcy8)    05163 Human cytomegalovirus infection     101698293 (Adcy8)   09165 Substance dependence    05032 Morphine addiction     101698293 (Adcy8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101698293 (Adcy8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101698293 (Adcy8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101698293 (Adcy8) Enzymes [BR:hgl01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101698293 (Adcy8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  101698293 NCBI-ProteinID:  XP_004837996 UniProt:  A0AAX6NVT3 LinkDB All DBs Position Un AA seq 1250 aa AA seqDB search MELSEVRCLGGSDELYTIQPTPSAGGGGSGSRPQRLLWQTAVRHITEQRFLHGHRGGGGG SGGSRKASHPAGGDPNHHAPQLACDSELPLHALGPGERAHSTGGSKVFPERSGSGSASGS GGGSDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKS EVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILVGFFTGIEVVICALVGVRKDTTSHTY LQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSL LQVALQVVIPRLAVTSINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARL RLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVK GFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHC CVEMGLSMIKTIRYVRSRTQHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLE SGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDI VKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQ SGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFI VLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINET YLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFIFTGV LAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDDLNHSGEDFLGTKEAS LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVAR HFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL LGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWEHLCALVDFSLALAETIQEINKHS FNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRVQVPEETYLILK DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPARRLPGQYSLAAVVLGLVQ SLNRQRQKQLLNENNNSGIIKGHYNRRTLLTPSGSEPGSQAEGTDKSDLP NT seq 3753 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgaggtgcgctgcctcggcggcagcgacgaactctacaccatccagccc acgccctcggccggcggcggcgggagcggctcccggccccagcggctgctgtggcagact gcggtgcggcacatcacggagcagcgcttcctccacggccaccggggcggcggcggcggg agcgggggctcccgcaaagcctcgcaccccgcgggcggcgaccccaaccaccacgcgccg cagctggcctgcgactccgagctgccgctccacgcgctgggccccggggagcgagcgcac agcaccggcggctccaaagtcttcccggaacgcagcggcagcggcagcgcgagcgggagc ggaggagggagcgacctgggcttcctgcacctggattgtgccccgagcaactcggatttc ttcctcagtgggggctacagctacaggggggtcattttccccaccctgcgcaactccttt aagtccagggatctggaacgcctctaccagcgctatttcctgggccagaggcgcaaatcc gaggtggtgatgaacgtgctggatgtgctgaccaaactcactctcttggtcctccacctg agcttggcctcggcgcccatggacccgctcaagggcatccttgtgggcttcttcactggc attgaggtggtgatctgcgccctggtgggggtcaggaaagacaccacctcgcacacgtac ctgcagtacagcggcgtggtcacctgggtggccatgaccacccagatcctggcagcaggc ctcggctacgggcttctgggcgacggcataggctacgtgctcttcacgctcttcgccacc tacagcatgctcccgctgcctctcacttgggccatcctggccggcctgggcacttcgctg ctgcaggtggccctccaagtggtcatcccccgcctggcggtcacttccatcaatcaggtt gtggcccaggcagtgctcttcatgtgcatgaacacggctggaatcttcatcagttacctg tctgaccgggcccagcgccaagccttcctggagacgcggaggtgtgtagaagctaggttg cgcctggagaccgagaaccaaagacaggagaggctcgtgttgtctgtgctcccccggttt gttgtcctggaaatgatcaacgacatgaccaacgtggaggacgagcacttgcagcaccag ttccaccgcatctacatccatcgctacgagaatgtcagtattctttttgcagacgtcaaa ggatttaccaacctctcgacgaccttgtccgctcaggagctggtcaggatgctgaacgag ctctttgccagatttgatcgactggcccatgagcatcattgccttcgcattaaaatccta ggggactgttactactgtgtttctggacttcctgagccccggcaggaccatgctcactgc tgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgcgatcaagaacacag catgacgtggacatgcgaattggaatccattcagggtcagtgctatgtggcgtgctgggg ctgagaaagtggcagtttgacgtctggtcttgggatgtggacatcgcgaacaaacttgaa tctggaggaatccctgggaggattcacatttccaaagccactctggactgcctcaacggt gactataatgtggaagagggtcatggtaaagaaaggaatgaattcttgaggaagcataat atagaaacctatttaattaagcaacctgaggaaagtctgctgtccttgcccgaagacatc gtcaaggaatcagtgagctcttcagacaggagaaacagtggggccacattcacagaagga tcctggagcccagaattgccctttgataacatcgtggggaaacagaacactctggctgct ctaacaagaaattcaataaatctgcttccaaaccatcttgcacaagctttgcatgtccag tctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggcgat aaattgagaagagaacatatcaaaccattctcactgatgtttaaagactccagcctggag cacaagtattctcaaatgagagatgaagtgttcaagtcaaatttggtctgcgcgtttatc gttcttctatttatcacagcaatacaaagtttgcttccttcttcaagagtgatgcccatg accatccagttctccattctgatcatgctgcactcagctctggttctcatcaccactgca gaggattataaatgcttgccgctcatcctccggaaaacttgctgttggattaacgagacc tacttggcccggaacgtcatcatctttgcatctatcttgattaatttcctcggtgccatc ctaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaat tcctcagctgtgtttacagatatctgctcctacccagagtacttcatcttcacgggggtg ctggccatggtgacctgtgcagttttcctccggctgaactccgttctgaagctggctgtg cttctgattatgattgccatctatgctctgctgaccgagaccatctacgcaggtctcttt ctgcgttatgatgacctgaaccacagtggcgaagatttcctggggacaaaggaagcatct ctactgctgatggccatgttcctcctggctgtattctaccatggacagcagctggagtac acagcccgcctagactttctctggcgagtgcaagccaaggaggagatcaatgagatgaag gagctgcgggaacacaatgagaacatgctccggaatatcttacccagccacgtggcccgc cacttcctggagaaagaccgtgacaatgaggagctgtattctcagtcctacgacgctgtt ggggtgatgttcgcctccattccagggtttgcagacttttactctcagaccgaaatgaac aaccaaggagtagaatgtttgcgcttgctgaatgagatcattgctgacttcgatgagctg ctgggtgaagaccggtttcaagacattgaaaagattaagaccattggcagcacctatatg gcagtgtcaggcctgtcaccagaaaaacagcagtgtgaagacaagtgggagcacctgtgt gccctggtggacttctctctggccctggccgaaaccatacaggagatcaacaagcactca ttcaataactttgagctccggatcggcatcagccacggctctgtggtggccggcgtgatt ggcgctaagaagccgcagtacgacatttggggcaaaactgtgaacctggcaagcaggatg gacagcacgggagtgagtggccgggtccaagttcccgaggagacctatctcatcctgaag gaccagggctttgcctttgactatcgtggggagatctacgtgaagggcatcagtgagcag gaaggaaaaatcaagacatactttcttctgggaagagtccagcccaacccgttcatcctg cccgcgagaagactgcccggccagtactccttggctgcggtcgtcctgggcctcgtccag tccctcaacaggcaaaggcagaaacagctcctcaatgaaaacaacaactccggcatcatc aaaggccattacaaccggcggacgttgctgacgcccagtgggtcggagccagggtcccaa gccgagggaaccgacaaatctgatttgccataa

DBGET integrated database retrieval system