Heterocephalus glaber (naked mole-rat): 101702773 Help Entry 101702773         CDS       T02812                                  Symbol Casp8 Name (RefSeq) caspase 8   KO K04398   caspase 8 [EC:3.4.22.61] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01524   Platinum drug resistance hgl04115   p53 signaling pathway hgl04210   Apoptosis hgl04215   Apoptosis - multiple species hgl04217   Necroptosis hgl04620   Toll-like receptor signaling pathway hgl04621   NOD-like receptor signaling pathway hgl04622   RIG-I-like receptor signaling pathway hgl04623   Cytosolic DNA-sensing pathway hgl04625   C-type lectin receptor signaling pathway hgl04657   IL-17 signaling pathway hgl04668   TNF signaling pathway hgl04932   Non-alcoholic fatty liver disease hgl04936   Alcoholic liver disease hgl05010   Alzheimer disease hgl05016   Huntington disease hgl05022   Pathways of neurodegeneration - multiple diseases hgl05132   Salmonella infection hgl05134   Legionellosis hgl05142   Chagas disease hgl05145   Toxoplasmosis hgl05152   Tuberculosis hgl05160   Hepatitis C hgl05161   Hepatitis B hgl05162   Measles hgl05163   Human cytomegalovirus infection hgl05164   Influenza A hgl05165   Human papillomavirus infection hgl05167   Kaposi sarcoma-associated herpesvirus infection hgl05168   Herpes simplex virus 1 infection hgl05169   Epstein-Barr virus infection hgl05170   Human immunodeficiency virus 1 infection hgl05200   Pathways in cancer hgl05203   Viral carcinogenesis hgl05416   Viral myocarditis hgl05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     101702773 (Casp8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     101702773 (Casp8)    04215 Apoptosis - multiple species     101702773 (Casp8)    04217 Necroptosis     101702773 (Casp8)    04115 p53 signaling pathway     101702773 (Casp8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101702773 (Casp8)    04621 NOD-like receptor signaling pathway     101702773 (Casp8)    04622 RIG-I-like receptor signaling pathway     101702773 (Casp8)    04623 Cytosolic DNA-sensing pathway     101702773 (Casp8)    04625 C-type lectin receptor signaling pathway     101702773 (Casp8)    04657 IL-17 signaling pathway     101702773 (Casp8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101702773 (Casp8)    05203 Viral carcinogenesis     101702773 (Casp8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101702773 (Casp8)    05161 Hepatitis B     101702773 (Casp8)    05160 Hepatitis C     101702773 (Casp8)    05164 Influenza A     101702773 (Casp8)    05162 Measles     101702773 (Casp8)    05168 Herpes simplex virus 1 infection     101702773 (Casp8)    05163 Human cytomegalovirus infection     101702773 (Casp8)    05167 Kaposi sarcoma-associated herpesvirus infection     101702773 (Casp8)    05169 Epstein-Barr virus infection     101702773 (Casp8)    05165 Human papillomavirus infection     101702773 (Casp8)   09171 Infectious disease: bacterial    05132 Salmonella infection     101702773 (Casp8)    05134 Legionellosis     101702773 (Casp8)    05152 Tuberculosis     101702773 (Casp8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101702773 (Casp8)    05142 Chagas disease     101702773 (Casp8)   09164 Neurodegenerative disease    05010 Alzheimer disease     101702773 (Casp8)    05016 Huntington disease     101702773 (Casp8)    05022 Pathways of neurodegeneration - multiple diseases     101702773 (Casp8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101702773 (Casp8)    05416 Viral myocarditis     101702773 (Casp8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     101702773 (Casp8)    04932 Non-alcoholic fatty liver disease     101702773 (Casp8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     101702773 (Casp8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hgl01002]     101702773 (Casp8) Enzymes [BR:hgl01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      101702773 (Casp8) Peptidases and inhibitors [BR:hgl01002]  Cysteine peptidases   Family C14: caspase family    101702773 (Casp8) SSDB OrthologParalogGFIT Motif Pfam:  Peptidase_C14 DED PYRIN Motif Other DBs NCBI-GeneID:  101702773 NCBI-ProteinID:  XP_004872352 UniProt:  A0AAX6QBR4 LinkDB All DBs Position Un AA seq 478 aa AA seqDB search MDFSTCLYNIGEQLDSDELASLKFLSLEHIPQRKQESITDAWMLFQRLQENRVLEEGNLS FLKELLFRISRLDLLAACLSTSREEMEQQLGTPGKAQISTYRVMLLQIAEDVTSQELKNF KFLLHREIPKCKLDDSMSLLDIFIEMEKRVILGKEKLDTLKSICEQVNRSLLLKISDYEA LHGEERMRLGQSPDASSNEEESFPTPGMLDFLGGQEKSQTLDQVYQMKNKPRGYCLIFNN YDFSEARKNIPQLGKMKDRKGTDFDAETLEGTFTELHFETVPCRNFTAQTICDMLQHYQG VDHGDRDCFICCVLSHGNSGIVYGTDGQEVPISELTSYFTGSKCPSLAGKPKVFFIQACQ GEKCQKAVCVESDSDENEAYLHEDLAFPCKAIPDEADFLLGMATVDSCVSYRDPTKGTWY IQTLCKSLRRRCPQGDDVLTILTEVNFEVGKKINPKNMGKQMPQPTFSLRKKLFFPID NT seq 1437 nt NT seq  +upstreamnt  +downstreamnt atggatttcagcacatgcctttacaatatcggggagcaactggacagtgacgagctggcc tccctcaagttcctgagcctggagcacatcccacagcggaagcaggagtccatcacagac gcctggatgttgttccagaggctccaggagaacagggtgctggaggaaggcaacctgtcc ttcctcaaggagctgcttttccggatcagcaggctggacctgctggctgcctgtctgagc actagcagggaggagatggagcagcagctcgggacccctggcaaggcccagatctccacc tacagggtcatgctgcttcagattgcagaagatgtaaccagccaagagctgaagaatttt aagtttctgctgcacagggagatccccaagtgtaagctggatgacagcatgagcctgctg gacatcttcatagagatggagaagagggtcatccttgggaaggagaagttggacaccctg aaaagcatctgtgagcaagtcaacaggagcctgctgctgaagatcagcgactacgaggca ctgcatggagaagaaagaatgaggctcggacaaagtccagatgcatcttcaaatgaggag gagtccttcccgacgccaggcatgctggacttcctgggaggacaggagaagtcacagacc ttggaccaagtttaccaaatgaaaaacaagcctcgggggtactgtttgatcttcaataat tatgattttagtgaggcacggaagaatatcccccagcttggcaaaatgaaggacaggaaa ggaacagatttcgacgcagagactttggaggggaccttcactgagcttcactttgagacg gttccttgccggaacttcacagcacagacgatctgtgacatgctgcagcactaccaaggc gtggaccacggggacagagactgcttcatctgctgtgtcctctcccacggaaacagcggc atcgtctatggcacggatggccaggaggtgcccatctctgagttaacctcttacttcact ggttccaaatgcccttcccttgcggggaaacccaaagtgttttttattcaggcttgtcaa ggggagaagtgccagaaagctgtatgtgtggagagtgactcagacgagaacgaagcctat ctacacgaggacttggcgtttccgtgtaaggccatcccggatgaggctgactttctgctg ggaatggccactgtggacagctgtgtttcctaccgagaccctacgaaggggacctggtac atccagacgctgtgcaaaagcctgcgaagaagatgtccgcaaggtgatgatgtcctcacc atcctgacagaagtgaactttgaagtgggcaaaaagattaacccgaagaacatggggaaa cagatgccccagccgaccttcagcctaaggaaaaagctgttcttccccattgactga

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