KEGG   Heterocephalus glaber (naked mole-rat): 101707562
Entry
101707562         CDS       T02812                                 
Symbol
Map2k2
Name
(RefSeq) mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl01522  Endocrine resistance
hgl04010  MAPK signaling pathway
hgl04012  ErbB signaling pathway
hgl04014  Ras signaling pathway
hgl04015  Rap1 signaling pathway
hgl04022  cGMP-PKG signaling pathway
hgl04024  cAMP signaling pathway
hgl04066  HIF-1 signaling pathway
hgl04068  FoxO signaling pathway
hgl04071  Sphingolipid signaling pathway
hgl04072  Phospholipase D signaling pathway
hgl04140  Autophagy - animal
hgl04148  Efferocytosis
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04210  Apoptosis
hgl04218  Cellular senescence
hgl04270  Vascular smooth muscle contraction
hgl04370  VEGF signaling pathway
hgl04371  Apelin signaling pathway
hgl04540  Gap junction
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04613  Neutrophil extracellular trap formation
hgl04620  Toll-like receptor signaling pathway
hgl04650  Natural killer cell mediated cytotoxicity
hgl04660  T cell receptor signaling pathway
hgl04662  B cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04720  Long-term potentiation
hgl04722  Neurotrophin signaling pathway
hgl04730  Long-term depression
hgl04810  Regulation of actin cytoskeleton
hgl04910  Insulin signaling pathway
hgl04912  GnRH signaling pathway
hgl04915  Estrogen signaling pathway
hgl04916  Melanogenesis
hgl04917  Prolactin signaling pathway
hgl04919  Thyroid hormone signaling pathway
hgl04921  Oxytocin signaling pathway
hgl04926  Relaxin signaling pathway
hgl04929  GnRH secretion
hgl04934  Cushing syndrome
hgl04935  Growth hormone synthesis, secretion and action
hgl05010  Alzheimer disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05132  Salmonella infection
hgl05135  Yersinia infection
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05164  Influenza A
hgl05165  Human papillomavirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05200  Pathways in cancer
hgl05205  Proteoglycans in cancer
hgl05206  MicroRNAs in cancer
hgl05207  Chemical carcinogenesis - receptor activation
hgl05208  Chemical carcinogenesis - reactive oxygen species
hgl05210  Colorectal cancer
hgl05211  Renal cell carcinoma
hgl05213  Endometrial cancer
hgl05214  Glioma
hgl05215  Prostate cancer
hgl05216  Thyroid cancer
hgl05218  Melanoma
hgl05219  Bladder cancer
hgl05220  Chronic myeloid leukemia
hgl05221  Acute myeloid leukemia
hgl05223  Non-small cell lung cancer
hgl05224  Breast cancer
hgl05225  Hepatocellular carcinoma
hgl05226  Gastric cancer
hgl05230  Central carbon metabolism in cancer
hgl05231  Choline metabolism in cancer
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101707562 (Map2k2)
   04012 ErbB signaling pathway
    101707562 (Map2k2)
   04014 Ras signaling pathway
    101707562 (Map2k2)
   04015 Rap1 signaling pathway
    101707562 (Map2k2)
   04370 VEGF signaling pathway
    101707562 (Map2k2)
   04371 Apelin signaling pathway
    101707562 (Map2k2)
   04066 HIF-1 signaling pathway
    101707562 (Map2k2)
   04068 FoxO signaling pathway
    101707562 (Map2k2)
   04072 Phospholipase D signaling pathway
    101707562 (Map2k2)
   04071 Sphingolipid signaling pathway
    101707562 (Map2k2)
   04024 cAMP signaling pathway
    101707562 (Map2k2)
   04022 cGMP-PKG signaling pathway
    101707562 (Map2k2)
   04151 PI3K-Akt signaling pathway
    101707562 (Map2k2)
   04150 mTOR signaling pathway
    101707562 (Map2k2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101707562 (Map2k2)
   04148 Efferocytosis
    101707562 (Map2k2)
  09143 Cell growth and death
   04210 Apoptosis
    101707562 (Map2k2)
   04218 Cellular senescence
    101707562 (Map2k2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101707562 (Map2k2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101707562 (Map2k2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101707562 (Map2k2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101707562 (Map2k2)
   04620 Toll-like receptor signaling pathway
    101707562 (Map2k2)
   04650 Natural killer cell mediated cytotoxicity
    101707562 (Map2k2)
   04660 T cell receptor signaling pathway
    101707562 (Map2k2)
   04662 B cell receptor signaling pathway
    101707562 (Map2k2)
   04664 Fc epsilon RI signaling pathway
    101707562 (Map2k2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101707562 (Map2k2)
   04929 GnRH secretion
    101707562 (Map2k2)
   04912 GnRH signaling pathway
    101707562 (Map2k2)
   04915 Estrogen signaling pathway
    101707562 (Map2k2)
   04917 Prolactin signaling pathway
    101707562 (Map2k2)
   04921 Oxytocin signaling pathway
    101707562 (Map2k2)
   04926 Relaxin signaling pathway
    101707562 (Map2k2)
   04935 Growth hormone synthesis, secretion and action
    101707562 (Map2k2)
   04919 Thyroid hormone signaling pathway
    101707562 (Map2k2)
   04916 Melanogenesis
    101707562 (Map2k2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101707562 (Map2k2)
  09156 Nervous system
   04720 Long-term potentiation
    101707562 (Map2k2)
   04730 Long-term depression
    101707562 (Map2k2)
   04722 Neurotrophin signaling pathway
    101707562 (Map2k2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101707562 (Map2k2)
   05206 MicroRNAs in cancer
    101707562 (Map2k2)
   05205 Proteoglycans in cancer
    101707562 (Map2k2)
   05207 Chemical carcinogenesis - receptor activation
    101707562 (Map2k2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101707562 (Map2k2)
   05230 Central carbon metabolism in cancer
    101707562 (Map2k2)
   05231 Choline metabolism in cancer
    101707562 (Map2k2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101707562 (Map2k2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101707562 (Map2k2)
   05225 Hepatocellular carcinoma
    101707562 (Map2k2)
   05226 Gastric cancer
    101707562 (Map2k2)
   05214 Glioma
    101707562 (Map2k2)
   05216 Thyroid cancer
    101707562 (Map2k2)
   05221 Acute myeloid leukemia
    101707562 (Map2k2)
   05220 Chronic myeloid leukemia
    101707562 (Map2k2)
   05218 Melanoma
    101707562 (Map2k2)
   05211 Renal cell carcinoma
    101707562 (Map2k2)
   05219 Bladder cancer
    101707562 (Map2k2)
   05215 Prostate cancer
    101707562 (Map2k2)
   05213 Endometrial cancer
    101707562 (Map2k2)
   05224 Breast cancer
    101707562 (Map2k2)
   05223 Non-small cell lung cancer
    101707562 (Map2k2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101707562 (Map2k2)
   05170 Human immunodeficiency virus 1 infection
    101707562 (Map2k2)
   05161 Hepatitis B
    101707562 (Map2k2)
   05160 Hepatitis C
    101707562 (Map2k2)
   05164 Influenza A
    101707562 (Map2k2)
   05163 Human cytomegalovirus infection
    101707562 (Map2k2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101707562 (Map2k2)
   05165 Human papillomavirus infection
    101707562 (Map2k2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101707562 (Map2k2)
   05135 Yersinia infection
    101707562 (Map2k2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101707562 (Map2k2)
   05022 Pathways of neurodegeneration - multiple diseases
    101707562 (Map2k2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101707562 (Map2k2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101707562 (Map2k2)
   01522 Endocrine resistance
    101707562 (Map2k2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101707562 (Map2k2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101707562 (Map2k2)
Protein kinases [BR:hgl01001]
 Serine/threonine kinases: STE group
  STE7 family
   101707562 (Map2k2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 101707562
NCBI-ProteinID: XP_004865826
UniProt: A0AAX6Q4M5
LinkDB
Position
Un
AA seq 407 aa
MLARRKPVLPALTINPAVAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDTKELEAIFGRPMLDSTEGQPQSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPHGVFSLDFQEFVNKCLIKNPAERADL
KMLMPSLPPSQNHTFIKRSEVEEVDFAGWLCRTLRLNQPSTPTRTAV
NT seq 1224 nt   +upstreamnt  +downstreamnt
atgctggcccggagaaagccggtgctgccggcgctcaccatcaaccccgccgtcgccgag
ggcccgtcccccaccagcgagggcgcctcagaggcgaacctagtggacctgcaaaagaag
ttggaggagctggaactagatgagcagcagaagaagcggcttgaggctttcctcacccag
aaggccaaggtcggtgagctcaaggacgatgacttcgaacggatctcagagctgggagct
ggcaatggcggtgtggtcaccaaggtccagcacagaccgtcaggcctcatcatggctcgg
aagctcatccacctggagatcaagccagccatccgcaaccagatcatccgagagctgcag
gtgctgcacgagtgcaactcaccctacattgtgggcttttacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggacggcggctccctggaccaggtgctgaaa
gaagccaagcggatccctgaagaaatcctggggaaagtcagcattgcggtactccggggc
ctggcatacctccgggagaagcaccagatcatgcaccgagacgtgaagccctccaacatc
ctggtcaactctcgaggggagatcaagctgtgtgactttggggtgagcgggcagctcatc
gactccatggccaactccttcgtggggactcggtcctacatgtctccggagcggctacag
ggcacacactactcggtgcagtcggacatctggagcatggggctgtccctggtggagctg
tccatcggcaggtaccccatccccccacccgacaccaaggagctggaggccatcttcggc
cggccaatgcttgacagcactgaaggacagccccagagcatctcaccacggccccggccc
cctggacgccccatcagcggtcatgggatggacagccggcccgccatggccatcttcgag
ctgctagactacatcgtgaatgagccaccgcccaagctgccccatggcgtgttcagcctg
gacttccaggagtttgtaaataaatgcctcattaagaacccagcggagcgcgcggacctg
aagatgctcatgccctcccttcctccctcgcagaaccacaccttcatcaagcgctccgag
gtggaagaggtggacttcgccggctggctgtgcagaaccctgcgcctcaaccagcccagc
acaccgacgcgcactgctgtgtga

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