Heterocephalus glaber (naked mole-rat): 101711587 Help Entry 101711587         CDS       T02812                                  Symbol Ptk2 Name (RefSeq) protein tyrosine kinase 2   KO K05725   focal adhesion kinase 1 [EC:2.7.10.2] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01522   Endocrine resistance hgl04012   ErbB signaling pathway hgl04062   Chemokine signaling pathway hgl04148   Efferocytosis hgl04151   PI3K-Akt signaling pathway hgl04360   Axon guidance hgl04370   VEGF signaling pathway hgl04510   Focal adhesion hgl04670   Leukocyte transendothelial migration hgl04810   Regulation of actin cytoskeleton hgl04935   Growth hormone synthesis, secretion and action hgl05100   Bacterial invasion of epithelial cells hgl05135   Yersinia infection hgl05146   Amoebiasis hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05170   Human immunodeficiency virus 1 infection hgl05200   Pathways in cancer hgl05202   Transcriptional misregulation in cancer hgl05205   Proteoglycans in cancer hgl05208   Chemical carcinogenesis - reactive oxygen species hgl05222   Small cell lung cancer hgl05417   Lipid and atherosclerosis hgl05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     101711587 (Ptk2)    04370 VEGF signaling pathway     101711587 (Ptk2)    04151 PI3K-Akt signaling pathway     101711587 (Ptk2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     101711587 (Ptk2)   09144 Cellular community - eukaryotes    04510 Focal adhesion     101711587 (Ptk2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     101711587 (Ptk2)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     101711587 (Ptk2)    04062 Chemokine signaling pathway     101711587 (Ptk2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     101711587 (Ptk2)   09158 Development and regeneration    04360 Axon guidance     101711587 (Ptk2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101711587 (Ptk2)    05202 Transcriptional misregulation in cancer     101711587 (Ptk2)    05205 Proteoglycans in cancer     101711587 (Ptk2)    05208 Chemical carcinogenesis - reactive oxygen species     101711587 (Ptk2)   09162 Cancer: specific types    05222 Small cell lung cancer     101711587 (Ptk2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101711587 (Ptk2)    05163 Human cytomegalovirus infection     101711587 (Ptk2)    05165 Human papillomavirus infection     101711587 (Ptk2)   09171 Infectious disease: bacterial    05135 Yersinia infection     101711587 (Ptk2)    05100 Bacterial invasion of epithelial cells     101711587 (Ptk2)   09174 Infectious disease: parasitic    05146 Amoebiasis     101711587 (Ptk2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101711587 (Ptk2)    05418 Fluid shear stress and atherosclerosis     101711587 (Ptk2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101711587 (Ptk2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101711587 (Ptk2)    01009 Protein phosphatases and associated proteins [BR:hgl01009]     101711587 (Ptk2) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101711587 (Ptk2) Protein kinases [BR:hgl01001]  Non-receptor tyrosine kinases   FAK family    101711587 (Ptk2) Protein phosphatases and associated proteins [BR:hgl01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      101711587 (Ptk2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Focal_AT Pkinase FERM_C_FAK1 FERM_N_2 FERM_M Kinase-like Haspin_kinase FERM_F2 ABC1 Motif Other DBs NCBI-GeneID:  101711587 NCBI-ProteinID:  XP_004837947 UniProt:  A0AAX6NVP8 LinkDB All DBs Position Un AA seq 1106 aa AA seqDB search MLLELAGQESLKPAGAVYMEKSGCSPFPMCWAKEYDRYLASSKIMAAAYLDPNLNHTPNS SAKTHLGTGMERSPCTMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHK VKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQ FTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEV LEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKE CFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSHSEDKDRKGML QLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKL ANNEKQGVRTHAVSMSETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIG EGQFGDVHQGVYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGV ITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAA RNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFG VCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRF TELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGF YPSPQHMVQANHYQVSGYPGSHGITAMPGSIYPGQASLLDQTESWNHRSQEIPMWQPNVE DSAALDLRGIGQVLPAHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDG SLQGLTGNQHIYQPVGKPDPAAPPKKPPRPGAPSHLGSLASLSSPGDSYNEGVKPWRLQP QEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLA TVDETIPVLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHA LAVDAKNLLDVIDQARLKMLGQTRPH NT seq 3321 nt NT seq  +upstreamnt  +downstreamnt atgttgttggaactggcaggccaagagtccctgaaaccagcaggtgctgtctatatggag aaaagcggctgtagtccatttccaatgtgttgggctaaagaatatgacagatacctagca tctagcaaaataatggcagctgcttaccttgacccaaacttgaatcatacaccaaattca agtgctaagactcacctgggtactggcatggaacgttccccttgtacaatggagcgagta ttaaaagtctttcattattttgaaagcaatagtgagccaaccacctgggccagtattatc aggcatggagatgcaactgatgtcaggggcatcattcagaagatagtggacagtcacaaa gtaaagcacgtggcctgctatggattccgcctcagtcacctgcggtcagaggaggttcac tggcttcatgtggacatgggtgtctccagtgtgagggagaagtatgagctcgcccaccca ccagaggagtggaaatatgaactgagaattcgttatttgccaaaaggatttctaaaccag tttactgaagacaagccaactctgaatttcttctatcaacaggtgaagagtgactacatg ttagagatagctgaccaagtggaccaggaaattgctctgaagttgggttgtcttgaaata cggcgatcatactgggagatgcggggcaatgcactagaaaagaagtctaactatgaagta ttagaaaaagatgttggtttgaagcgattttttcctaagagtttactggattctgtcaag gccaaaacactaagaaaactgatccaacaaacatttagacagtttgccaaccttaataga gaagaaagtattctgaaattctttgagatcctctctccagtgtacagatttgacaaagaa tgcttcaaatgtgcccttgggtcaagctggattatttcagtggaactggctatcggcccg gaagaagggatcagttacctaacagacaaaggctgcaatcccacacatctggccgacttc aaccaagtgcagaccattcagtattcacacagtgaagacaaggacagaaaaggaatgctg cagctcaaaatagcaggtgctcctgagcctctcacagtgacggcaccatccctaaccata gcagagaacatggctgacctgatagacggatactgtcgactagtgaatggagccacacag tcctttatcatcagaccccagaaagaaggcgaacgggctttgccatcaattcccaagttg gccaacaatgaaaagcagggtgtccgaacacatgctgtctccatgtcagagacagatgat tatgctgagattatagatgaagaagacacttacaccatgccttcaaaaagctatggaata gatgaagccagggattatgagattcagagagaaagaatagaacttggacgatgtattgga gaaggccaatttggtgatgtacatcagggcgtgtatatgagtccagagaatccagctttg gcagttgcaattaaaacatgtaaaaactgtacttcggacagcgtgagagagaaatttctt caagaagccttaactatgcggcagtttgaccatcctcatattgtgaagctgattggagtc atcacagagaatcctgtctggataataatggagctgtgcacacttggagagctgaggtca tttttgcaagtgaggaaatacagcttggatctggcatctttgattctgtatgcctatcag cttagtacagcacttgcatatttggagagcaaaagatttgtgcacagggacattgctgct cgaaatgttctggtgtcctcaaatgattgtgtaaagttaggagactttgggttatcccga tacatggaagacagtacttactacaaagcttccaaaggaaaattgcctattaaatggatg gctccagagtcaatcaattttcgacgttttacctcagctagtgacgtatggatgtttggt gtatgtatgtgggagatactgatgcatggtgtgaagccttttcaaggagtgaagaacaat gatgtgatcggtcgaattgaaaatggggaaagattaccaatgcctccaaattgtcctcct accctctacagccttatgacgaaatgctgggcctatgaccccagcaggcggcccaggttt actgaacttaaagctcagctcagcacaatcctggaggaagagaaggcccagcaagaagaa cgaatgaggatggagtcgagaagacaggccactgtgtcctgggactctggaggatctgat gaagcaccacccaagcccagcagacctggttatcctagtccaaggtccagtgaaggattt tatcccagtccgcagcacatggtgcaagccaatcattaccaggtctctggctaccctggt tcacacggaatcacagctatgcctggcagcatctacccaggtcaggcatctctcttggac cagacagagtcatggaatcatagatctcaagagatacccatgtggcagcccaacgtggag gactcagcggccttggaccttcgcgggattgggcaggtcttgccagcccacctgatggaa gagcggctgatccgacagcagcaggaaatggaagaagatcagcgctggttggaaaaagag gagagatttctgaaacctgatgtgaggctctcacgaggcagcatcgacagggaggatggg agtcttcagggtctgactggaaaccaacacatctatcagcctgtaggtaaaccagatcct gcagctccaccaaagaaaccaccacgccctggagcccccagtcatctaggcagcctcgcc agcctcagcagccctggggacagctacaatgagggtgttaagccatggaggcttcagccc caggaaatcagccctcctcctactgccaacctggaccggtccaatgacaaggtgtatgag aatgtgacgggcctggtgaaagctgtcatcgagatgtccagtaaaatccaaccagcccca ccagaggagtatgttcctatggtgaaggaagttggcttggccctgcggacgttattggcc acggtggatgagaccattcctgtcctcccagccagcacgcatcgagagatcgagatggcg cagaagctgctgaactctgacttgggagagctcatcaacaagatgaagcttgcccagcaa tacgtcatgaccagcctacagcaggagtacaagaagcagatgctgaccgcggctcatgcc ctggctgtggatgccaaaaacctgcttgatgtcattgaccaagcaagactgaaaatgctt gggcagacaagaccacactga

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