Heterocephalus glaber (naked mole-rat): 101714396
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Entry
101714396 CDS
T02812
Symbol
Lck
Name
(RefSeq) LCK proto-oncogene, Src family tyrosine kinase
KO
K05856
lymphocyte cell-specific protein tyrosine kinase [EC:
2.7.10.2
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl04064
NF-kappa B signaling pathway
hgl04380
Osteoclast differentiation
hgl04650
Natural killer cell mediated cytotoxicity
hgl04658
Th1 and Th2 cell differentiation
hgl04659
Th17 cell differentiation
hgl04660
T cell receptor signaling pathway
hgl05135
Yersinia infection
hgl05166
Human T-cell leukemia virus 1 infection
hgl05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
101714396 (Lck)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
101714396 (Lck)
04660 T cell receptor signaling pathway
101714396 (Lck)
04658 Th1 and Th2 cell differentiation
101714396 (Lck)
04659 Th17 cell differentiation
101714396 (Lck)
09158 Development and regeneration
04380 Osteoclast differentiation
101714396 (Lck)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101714396 (Lck)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
101714396 (Lck)
09171 Infectious disease: bacterial
05135 Yersinia infection
101714396 (Lck)
09163 Immune disease
05340 Primary immunodeficiency
101714396 (Lck)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hgl01001
]
101714396 (Lck)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hgl03036
]
101714396 (Lck)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
101714396 (Lck)
Protein kinases [BR:
hgl01001
]
Non-receptor tyrosine kinases
SRC family
101714396 (Lck)
Chromosome and associated proteins [BR:
hgl03036
]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
101714396 (Lck)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_2
SH3_9
ABC1
Haspin_kinase
SH2_1
SH3_16
Motif
Other DBs
NCBI-GeneID:
101714396
NCBI-ProteinID:
XP_004850906
LinkDB
All DBs
Position
Un
AA seq
517 aa
AA seq
DB search
MRPTFWGTMGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLLMRNGSEVRDPLVTYE
DSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSLTTGQEGFIP
FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQ
NQGEVVKHYKIRNLDKGGFYISPRITFPGLHELVRHYTNTPDGLCTRLSRPCQTQKPQKP
WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLM
KQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGM
AFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI
NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVQPDNCPEELYHL
MMLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
NT seq
1554 nt
NT seq
+upstream
nt +downstream
nt
atgagacccacattttgggggaccatgggctgtagctgcagctcaaaccctgaagatgac
tggatggaaaacattgatgtgtgtgagaactgccattatcccatagtcccactggatggc
aaggccacgcttctcatgcggaatggctctgaagtacgggacccactggtcacctatgag
gactccaatccacctgcctccccactccaagacaacctggttatcgccctgcacagctat
gagccctcgcacgatggagatctgggattcgagaagggagagcaactccgcatcctggag
cagaatggcgagtggtggaaggcacagtccctgaccacgggacaggaaggtttcatcccc
ttcaacttcgtggccaaagcaaatagcctggagcctgaaccttggttcttcaagaacctg
agccgcaaggacgcggagcgacagctcctggcgccagggaacacgcacggttcctttctg
atccgcgagagcgagagcactgcgggatcattttcactgtcggtccgggatttcgaccaa
aaccaaggagaggtggtgaaacattacaagatccgtaacttggacaaaggcggcttctac
atctcccctcgcatcacctttcctgggctgcatgaactggtccgtcattataccaatact
cctgatggtctctgcacgaggctgagccgcccctgccaaacccagaagccccagaagccg
tggtgggaggatgagtgggaggttcccagggagacgttgaagctggtggagcgcctgggg
gccgggcagttcggggaagtgtggatggggtactacaatgggcatacgaaggtggcagtg
aagagcctgaagcaaggcagcatgtcaccggacgccttcctggctgaggccaacctcatg
aagcagctgcagcaccagcggctggtccggctctacgccgtggtcacgcaggagcccatc
tacatcatcacggagtacatggagaacgggagcctagtggattttctcaagacccccccg
ggcatcaagttgaccatcaataaactcttggacatggcagcccaaattgcagaaggtatg
gcatttattgaagagcggaattatatccaccgtgacctgcgggctgccaacatcctggtg
tctgacaccctgagctgcaagatcgcagactttggcttagcacgcctcatcgaggacaat
gagtacacagcgagggagggggccaaatttcccattaaatggacagcaccagaagccatt
aactatggaacattcactatcaagtcggatgtgtggtcttttgggattctgctgacggag
attgttacccacggccgcatcccttacccagggatgaccaatcctgaggtaattcagaac
ttggagcgaggctaccgcatggtacaacctgacaattgtccagaggagttgtaccacctc
atgatgctgtgctggaaggagcgcccagaggaccggcccacctttgactaccttcgcagt
gtgctggaggacttcttcacggccacagagggccagtaccagccccaaccttga
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