Heterocephalus glaber (naked mole-rat): 101714930 Help Entry 101714930         CDS       T02812                                  Symbol Pten Name (RefSeq) phosphatase and tensin homolog   KO K01110   phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00562   Inositol phosphate metabolism hgl01100   Metabolic pathways hgl01521   EGFR tyrosine kinase inhibitor resistance hgl04068   FoxO signaling pathway hgl04070   Phosphatidylinositol signaling system hgl04071   Sphingolipid signaling pathway hgl04115   p53 signaling pathway hgl04140   Autophagy - animal hgl04150   mTOR signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04218   Cellular senescence hgl04510   Focal adhesion hgl04931   Insulin resistance hgl05165   Human papillomavirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05206   MicroRNAs in cancer hgl05208   Chemical carcinogenesis - reactive oxygen species hgl05213   Endometrial cancer hgl05214   Glioma hgl05215   Prostate cancer hgl05218   Melanoma hgl05222   Small cell lung cancer hgl05224   Breast cancer hgl05225   Hepatocellular carcinoma hgl05230   Central carbon metabolism in cancer hgl05235   PD-L1 expression and PD-1 checkpoint pathway in cancer hgl05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     101714930 (Pten)  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     101714930 (Pten)    04070 Phosphatidylinositol signaling system     101714930 (Pten)    04071 Sphingolipid signaling pathway     101714930 (Pten)    04151 PI3K-Akt signaling pathway     101714930 (Pten)    04150 mTOR signaling pathway     101714930 (Pten)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101714930 (Pten)   09143 Cell growth and death    04115 p53 signaling pathway     101714930 (Pten)    04218 Cellular senescence     101714930 (Pten)   09144 Cellular community - eukaryotes    04510 Focal adhesion     101714930 (Pten)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101714930 (Pten)    05206 MicroRNAs in cancer     101714930 (Pten)    05208 Chemical carcinogenesis - reactive oxygen species     101714930 (Pten)    05230 Central carbon metabolism in cancer     101714930 (Pten)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101714930 (Pten)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     101714930 (Pten)    05214 Glioma     101714930 (Pten)    05218 Melanoma     101714930 (Pten)    05215 Prostate cancer     101714930 (Pten)    05213 Endometrial cancer     101714930 (Pten)    05224 Breast cancer     101714930 (Pten)    05222 Small cell lung cancer     101714930 (Pten)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101714930 (Pten)    05165 Human papillomavirus infection     101714930 (Pten)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     101714930 (Pten)   09167 Endocrine and metabolic disease    04931 Insulin resistance     101714930 (Pten)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101714930 (Pten)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:hgl01009]     101714930 (Pten) Enzymes [BR:hgl01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.3  Phosphoric-monoester hydrolases     3.1.3.16  protein-serine/threonine phosphatase      101714930 (Pten)     3.1.3.48  protein-tyrosine-phosphatase      101714930 (Pten)     3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase      101714930 (Pten) Protein phosphatases and associated proteins [BR:hgl01009]  Protein tyrosine phosphatases (PTPs)   Class I PTPs (Dual specificity phosphatases)    Phosphatase and Tensin homologs (PTEN)     101714930 (Pten) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PTEN_C2 Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase Dermcidin PTPlike_phytase Y_phosphatase3 DUF3256 Motif Other DBs NCBI-GeneID:  101714930 NCBI-ProteinID:  XP_004858402 LinkDB All DBs Position Un AA seq 603 aa AA seqDB search PRRFVSASPERNGGSRGLGREPAKARRRRLPLLERGVEAAVAAAAGRGPESPVTISRAGD AGELVSPLLLPPTRRRRRRRHLQGPGPALSLPSAAAAHPPARAQEAAAGGSRSEDCSWYP HPAAAAARPLAAEEKQAQSLQPSSSRRSSHYPAAVQNQAAAERGASATKSRAISILQKKP RHQQLLPSLSSFFFSHRLPDMTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAE RLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLEL IKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQL KVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI PGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPN FKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQI TKV NT seq 1812 nt NT seq  +upstreamnt  +downstreamnt ccgcgccgcttcgtctctgcttctcctgagaggaacggtggaagccgcgggctcgggcgg gagccggcgaaggctcggcggcggcgcctcccgctcctggagcggggggtagaagcggcg gtagccgcggcggcggggagggggcccgagtcgcctgtcaccatttccagggctggggac gccggagagttggtctctccccttctcctgcctccaacacggcggcggcggcggcggcgg cacctccagggacccgggccggctctaagcctcccctccgccgccgccgcacaccccccg gcccgggctcaggaggctgctgcaggaggcagccgttccgaggattgttcgtggtatccc catcccgctgctgccgctgccaggccgctggctgctgaagagaagcaggcccagtcgctg caaccatctagcagccgccgcagcagccattacccggccgcggtccagaaccaagcggca gcagagcgaggggcatcggcgaccaagtccagagccatctccatcctgcagaagaagccc cgccaccagcagcttctgccatctctctcctcctttttcttcagccacaggctcccagac atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag cataaaaaccattacaagatatacaatctatgtgctgaaagacattatgacaccgccaaa tttaactgcagagttgcacagtatccttttgaagaccataacccaccacagctagaactt atcaaacctttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca gcaattcactgtaaagctggaaagggacggactggtgtaatgatttgtgcatatttatta catcggggcaaatttttaaaggcacaagaggccctcgatttctatggagaagtaaggacc agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta aaggtgaagatatattcctccaattcaggacccacaagacgggaagacaagttcatgtac tttgagttccctcagccgttgcctgtgtgtggtgacatcaaagtagagttcttccacaaa cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacgttcttcata ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctgtgtgatcaagaaatt gatagtatttgcagtatagagcgtgcagataatgataaagaatatctagtacttacttta acaaaaaatgatctcgacaaagcaaataaagataaggcaaaccgatatttttctccaaat tttaaggtgaagctgtacttcacaaaaacagtagaggagccatcaaatccagaggctagc agttcaacttctgtaacgccagatgttagtgacaatgaacctgatcattatagatattct gacaccactgactctgacccagagaacgagccttttgatgaagatcagcacacacaaatt acgaaagtctga

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