Heterocephalus glaber (naked mole-rat): 101716800
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Entry
101716800 CDS
T02812
Symbol
Hsd11b1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl00140
Steroid hormone biosynthesis
hgl00980
Metabolism of xenobiotics by cytochrome P450
hgl01100
Metabolic pathways
hgl05204
Chemical carcinogenesis - DNA adducts
Module
hgl_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
101716800 (Hsd11b1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
101716800 (Hsd11b1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
101716800 (Hsd11b1)
Enzymes [BR:
hgl01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
101716800 (Hsd11b1)
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Ortholog
Paralog
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
THF_DHG_CYH_C
2-Hacid_dh_C
Shikimate_DH
Methyltransf_25
NAD_binding_2
Pyr_redox_2
SIS
Epimerase
Pyr_redox_3
3HCDH_N
Pyr_redox
Motif
Other DBs
NCBI-GeneID:
101716800
NCBI-ProteinID:
XP_004862093
UniProt:
A0AAX6PYX4
LinkDB
All DBs
Position
Un
AA seq
307 aa
AA seq
DB search
MQGLLGPGPFLMAFLKKYLLPILMVLLAYYYYSAHEEFRPEMLRGKKVIVTGASKGIGRE
MAYHLAKMGAHVVVTSRSKEALQKVVSRCSELGAASAHYIAGTMEDMNFAEQFVAEAGKL
MGGLDMLILNHVFYSPMTFFNRDTDMVRRSMEVNFHSFVVLSAAALPMLKQSNGSIGVVS
SVAGKIPHPLIAPYSASKFALDGFFSSIRKEFAVTRVNVSISLCILGLIDTETAMKGTSG
VYEGYAAPKEECALEIIKGTALRQEEVHYSYMPWSSILLQNPGRKVMEFLSTRMFRWDKL
KSNQKSP
NT seq
924 nt
NT seq
+upstream
nt +downstream
nt
atgcaagggctcctcgggccaggtccctttctgatggcttttctgaaaaaatacctcctc
cccattctgatggtcctcttggcctactactactattctgcacatgaggagttcagacca
gagatgctccgaggaaagaaagtgattgtcacaggggccagcaaggggattggaagggaa
atggcgtatcacctggcgaagatgggagcccatgtggtggtgacatcgaggtcaaaagaa
gccctgcagaaggtggtgtcccgctgctcggaactcggcgcggcctccgcacactacatt
gctggcaccatggaagacatgaacttcgcggaacaatttgttgccgaagcaggaaagctc
atggggggactagacatgctcattctcaaccacgtcttctactctcctatgacttttttc
aatcgtgacactgacatggtgcgtcgaagcatggaggtcaacttccacagctttgtggtc
ctgagtgcagctgccttgcccatgctgaagcagagcaatgggagcattggtgtcgtctcc
tcggtggccgggaaaataccgcaccctctgattgctccctattctgccagcaagttcgct
ctggatggattcttctcgtccattaggaaagaatttgcagtgaccagagtcaacgtgtcg
atctctctgtgtatcctcggcctcatagacacagagacagccatgaaggggacttctggg
gtttacgaaggctatgcagctcctaaggaggagtgcgccctggagatcatcaaagggaca
gccctgcgccaggaggaagtgcactacagctacatgccctggagctcaatcctgctccaa
aacccagggaggaaggtcatggagttcctctccacaaggatgttccgatgggacaaactg
aagagcaaccagaaatccccttga
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