Heterocephalus glaber (naked mole-rat): 101719081 Help Entry 101719081         CDS       T02812                                  Symbol Irs2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04022   cGMP-PKG signaling pathway hgl04068   FoxO signaling pathway hgl04081   Hormone signaling hgl04140   Autophagy - animal hgl04152   AMPK signaling pathway hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04910   Insulin signaling pathway hgl04920   Adipocytokine signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04930   Type II diabetes mellitus hgl04931   Insulin resistance hgl04932   Non-alcoholic fatty liver disease hgl04935   Growth hormone synthesis, secretion and action hgl05010   Alzheimer disease hgl05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     101719081 (Irs2)    04022 cGMP-PKG signaling pathway     101719081 (Irs2)    04152 AMPK signaling pathway     101719081 (Irs2)   09133 Signaling molecules and interaction    04081 Hormone signaling     101719081 (Irs2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101719081 (Irs2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101719081 (Irs2)    04923 Regulation of lipolysis in adipocytes     101719081 (Irs2)    04920 Adipocytokine signaling pathway     101719081 (Irs2)    04935 Growth hormone synthesis, secretion and action     101719081 (Irs2)   09149 Aging    04211 Longevity regulating pathway     101719081 (Irs2)    04213 Longevity regulating pathway - multiple species     101719081 (Irs2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     101719081 (Irs2)   09164 Neurodegenerative disease    05010 Alzheimer disease     101719081 (Irs2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101719081 (Irs2)    04932 Non-alcoholic fatty liver disease     101719081 (Irs2)    04931 Insulin resistance     101719081 (Irs2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Mcp5_PH Motif Other DBs NCBI-GeneID:  101719081 NCBI-ProteinID:  XP_004858614 UniProt:  A0AAX6PS10 LinkDB All DBs Position Un AA seq 1308 aa AA seqDB search MASPPRQGAPGPAGGDGPNLNNNNNNNNNNHGVRKCGYLRKQKHGHKRFFVLRGPGAGGD DGGAGGGPAAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNVNKRADAKHKYLIALYT KDEYFAVAAENEQEQEGWYRALADLLSEGRAAAAGDAPPVATAPAATPCSAPLPGALGGS AEDADGPGASSASAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVT LQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFE FRPRSKSQSSGSSATHPISVPGARRHHHLVHLPPSQTGLVRRSRTDSLAATPPAAKGAPC RVRTASEGDGGAAAGAGAGAAVSAAGARPGSVAGSPLSPGPARAPLSRSHTLSAGCGARG GKAGLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSASYPLPPGPAPPLPHPL PHPLGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSSHRSNTPESIAETPPARD GAVGELYGYMSMDRPSGPLGRPYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSA SLDEYTLMRATFSGSSGRLCPPFPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGY MPMTPGAALLGSASDDYMPMSPTSVSAPKQILHPRAAPAAALPPSAPPVPAAPSPAGKTF PGPVGGYKAGSPAESSPEDSGYMRMWCGSKLSVESADPKLLASGDYLNMSPSEAGPAGTP PDFFSAALQGAGEGLRSVPGCCYSSLPRSYKGPYLCGGADSDQYVLMSSPVGRILEEEGL ESPATPGAPPWTGRDSHIQPHHLAAAVPAPMRPGSNAGGRPEGFFGQRCRAVRPTRLSLE GLQTLPSMHEYPLPPEPRSPGEYINIDFGEAGPRLSPPAPSLLASAASPSPLLSASSPAS SLSLGSGTPGTSSDSRQRSPLSDYMNLGFSSPKSPKPGVLSPEAASPYPPLPPRPAASLS SLQQQPPPPVPGELYRLPPAPSAAPASQGPSAGASVSSQTADSSDYAEMAFGLAAPPKPE GARVSSPTAGLKRLSLRGQGSGLEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSS TATVTPVSPSFAHNPKRHSSASVENVSLRKSSESGGGGAEEPLTAPGHSTLARPRASGQP GGLGGCPAGGGSPMRREAPVAFPKGLSYIAINVKEEAGLSPQMPPPQPGDKTSWGRTRSL GGLLSAVGGSGSSGACGGPGPAALSSPNSYASLDFLSHHLKEATAVKE NT seq 3927 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgcggcagggagcccctgggccagcgggcggtgacggccccaacctg aataacaacaacaacaacaacaacaacaaccacggcgtgcgcaagtgcggctacctgcgc aagcagaagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggggac gacgggggcgcgggcggggggccggcggcgccgcagcccccgcggctcgagtactacgag agcgagaagaagtggcggagcaaggcgggcgcgccgaagcgggtgatcgcgctcgactgc tgcctgaatgtcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacacc aaggacgagtacttcgctgtggcggccgagaacgagcaggagcaggagggctggtaccgc gcgctcgccgacctgctcagcgagggccgcgcggccgccgccggcgacgcgccccctgtg gccacggcccccgccgccacaccctgcagcgcccccctgccgggggcgctgggcggctcg gccgaggacgcggacgggccgggggcgtcctcggcctccgcctaccgcgaggtgtggcag gtgaacctgaagcccaagggcctgggccagagcaagaacctgacgggcgtgtaccgcctg tgcctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtccgtgacg ctgcagctcatgaacatccgccgctgcggccactcggacagcttcttcttcatagaggtg gggcgctcggccgtcacgggccccggcgagctgtggatgcaggccgacgactcggtggtg gcgcagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgag ttccgcccgcgcagcaagagccagtcctcgggctcgtcggccactcaccccatcagtgtg cccggcgcgcgccgccaccaccacctggtgcacctgcccccgagccagaccggcctggtg cgccgctcgcgcaccgacagcctggccgcaaccccgcccgccgccaagggcgccccgtgt cgcgtgcgtacggccagcgagggcgacggcggcgccgcggccggggccggggccggggcg gcggtgtctgcggcgggcgcgcgtccaggctcggtggccgggagccccctgagccccgga ccggcgcgcgcgcccctgagccgctcgcacacgctgagcgccggctgcggggcccggggc ggcaaggcgggcctggctccggcagggggcgcgctgcagcacagccgctccatgtccatg cctgtggcgcactctccccctgctgccaccagcccgggcagtctgtcgtccagcagcggc cacggctcggcctcctacccgctgccgcccggcccggccccgccgctgccgcaccccctg ccccacccgctgggacagcgaccctccagcggcagcgcctcggcctcgggctctccgagc gacccgggcttcatgtccctggacgagtacgggtctagcccgggcgacctgcgagccttc tgcagcagccaccgcagcaacacgcccgagtccatcgcggagacgcccccggcgcgggat ggcgcggtgggcgagctgtacgggtacatgagcatggacaggccctcgggccccttggga cgcccctaccgcagggtctcgggggacgcggcgcaggacctggaccggggcctgcgaaag cggacctactcgctgaccacgcccgcgcgccagcgccccgtgccccagccgtcgtccgcc tcgctggatgagtacacgctcatgcgggccaccttctcgggcagctccggccgcctgtgc ccgccctttcctgcgtcttcgcccaaagtggcctaccacccctatccggaggactatggg gacatcgagatcggctcacaccggagctccagcagcaacctgggggcggacgatggctac atgccgatgacccctggtgcagctctgctgggcagtgccagcgacgactacatgcccatg agccccaccagcgtgtctgccccgaagcagatcctgcatccgagggctgcaccggccgcg gccctgcccccctcggcgccaccggtgccagctgccccctccccagcgggcaagaccttc cccgggcctgtgggaggctacaaggccggctcacctgcggagagctctccagaggacagc gggtacatgcgcatgtggtgtgggtccaagctgtctgtggagagcgccgaccccaagctg ctggccagcggggactacctcaacatgtcccccagcgaggcgggcccggccggcaccccg cccgacttcttctccgcagctctgcagggcgctggggaggggctcagaagtgtccccggc tgctgctacagctccttgccccgctcctacaagggtccttacctgtgtggcggggcagac agtgaccagtacgtgctcatgagctccccggtgggccggatcctggaggaggagggactg gagtccccggccaccccaggggctcccccatggacgggcagggacagccacatccagccg catcacctagcagcagcagtgcctgcccccatgaggccaggcagcaacgctggtgggcgc cctgagggcttctttggccagcgctgccgggcagtgcgccccacacgcctgtccctagag ggcttgcagacgctgcccagcatgcatgagtaccccctgcccccagagcccaggagccct ggcgagtacatcaacattgacttcggggaggcgggcccccggctgtccccgccggcccct tcgctgctggcgtctgcggcctcaccctccccgctgctgtctgccagcagcccggcctcc tccctctccctgggctcaggcacgccgggcaccagcagtgacagcagacagcgctccccg ctgtccgactacatgaacctgggcttcagctcccccaagtcccccaagccgggggtcctg tcccccgaggccgcttccccatacccgccgctgccccctcgtcctgcggcctccctgtcc tccctgcagcagcagcccccaccgccggtccccggggagctgtaccgcctgcctcccgca cccagtgcggcccctgcctcccagggccccagcgctggtgcctcggtgtcctcccagact gctgacagcagcgactacgccgagatggccttcggcctggcggcgcccccgaagccggaa ggtgcccgagtgagcagccccacggcgggcctgaagcggctgagcctcaggggtcagggg tcggggctggaggccttcctgcaggctggccagccccccgacccgcaccggggcgccaag gtcatccgcgcagacccgcaggggggccgccgccgccacagctcggagactttctcctcc actgccacggtcacccccgtgtccccatccttcgctcacaaccccaagcgccacagctcg gcctctgtggagaacgtttctctccggaagagcagtgagagtggtggcggtggggctgag gagccgctcaccgccccaggacactcgacgttggcgcggcccagggcctccggtcagccc gggggcctgggtggctgcccggcgggcggcggctcccccatgcgcagagaagcccccgtg gcttttccgaaaggcctcagctacatcgccatcaacgtgaaggaggaggcagggctgtcc ccgcagatgccgcccccgcagccaggggacaagacctcgtggggccggacccggagcctg gggggcctcctcagcgcggtagggggcagcggcagcagtggggcttgtgggggcccaggc cctgccgccctgtcctcccccaacagctacgccagcctggacttcctgtcccatcacctg aaggaagccacggccgtgaaagagtga

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