Heterocephalus glaber (naked mole-rat): 101719321 Help Entry 101719321         CDS       T02812                                  Symbol Irs4 Name (RefSeq) insulin receptor substrate 4   KO K17446   insulin receptor substrate 4 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04022   cGMP-PKG signaling pathway hgl04068   FoxO signaling pathway hgl04081   Hormone signaling hgl04140   Autophagy - animal hgl04152   AMPK signaling pathway hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04910   Insulin signaling pathway hgl04920   Adipocytokine signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04930   Type II diabetes mellitus hgl04935   Growth hormone synthesis, secretion and action hgl05010   Alzheimer disease Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     101719321 (Irs4)    04022 cGMP-PKG signaling pathway     101719321 (Irs4)    04152 AMPK signaling pathway     101719321 (Irs4)   09133 Signaling molecules and interaction    04081 Hormone signaling     101719321 (Irs4)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101719321 (Irs4)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101719321 (Irs4)    04923 Regulation of lipolysis in adipocytes     101719321 (Irs4)    04920 Adipocytokine signaling pathway     101719321 (Irs4)    04935 Growth hormone synthesis, secretion and action     101719321 (Irs4)   09149 Aging    04211 Longevity regulating pathway     101719321 (Irs4)    04213 Longevity regulating pathway - multiple species     101719321 (Irs4)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101719321 (Irs4)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101719321 (Irs4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH_11 PH_8 DUF4214 Motif Other DBs NCBI-GeneID:  101719321 NCBI-ProteinID:  XP_004861504 UniProt:  A0AAX6PX10 LinkDB All DBs Position Un AA seq 1262 aa AA seqDB search MASCSFARDQATRTLRAAVAAAAAALAAVATNPLLSSGTSTALIGTRLSCPGAMWLSTAT GSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH SVRAAAAAAAAATSGTPVPALIPPRRVITLYQCFSVSQRADARYRHLIALFTQNEYFAMV AENETEQESWYLLLSRLILESKRRRCGMLGAQPDGEPAALAAAAAAEPPFYKDVWQVVIK PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSVNIGAHLLTLLSARRH LGLLPLEPGGWLRRSRFEQFCHFRAIGDRDDEMLFARRFIAPSEPVPPSRRGRLQVPRPR RSRRAISVPASFFRRLAPSPVHSPNPEEASKDRACEALASGRGNSRGKGKEGQEGNGGDY MPMNNWGSGNGRDSGGGQGSSGQGSSSQSSGRNQCSSGRQGSGSGQGSNGGQGSGGQRSG GQGARGNQSPGDGHNTTGSHGSGNGQGPGSGHGSGGSQRPRDGHGSGGGKNSGGSKGSGS EKSTDGDGDHAKSLKKRSYFGKFTPGKQPQMAPPPPPPPPPAGATNGKGKSGGRFRLYFC ADRGPTKERKDTKEMRDTETPEGVARGSHRARAFDEDEDDPYVPMRPGVAAPLASSSDYM PMAPQNVSASKQRHSRSPFEDSRGYMMMFPRVSPSSAQSTPKGPDPNKEDDSKDNDSDGD YMFMAPGAGAIPKSPRNPQGGSSSKSWSSYFLLPNSFQSSPLGQSDHSEYVPMLPGKFLG RALDKEGSSNWGLKDGASKPSLEGSFSKAGDGGSPSKPSDDEPPKNKAKRPNQLSFITKG NKIKPKPQKPTQKQREADSFSGYVNIDFTKRDSSMPAPSARGLSHSLGIIADPRQSAFSN YMNVEFRVQFPNPASHLSDLLRAIPGSNPLFLEGAGWPLLPLPPRAAGSNSNVEEGDYIE VIFNPAMTPAVPFADSAIRYDAETGRIYVVNPFSELCMDISLSPSRRSEPPPVARLLQEE QDTRCSQSRSQSFFAAVRAAVSAFLTDGHQRAISAAPSSAAAPAEAPTLAVGRGLAAASA LAVAPGLGAAAAGLEAAAGFDSASPRGFQPVADAAGTEAVREALDNAGGANPRTPNPPAD LARGENAAGGAAAAAEGPPPPPRHRWVPRPPEREESEDEDETYVRMDFARPDNKKFHSPK RE NT seq 3789 nt NT seq  +upstreamnt  +downstreamnt atggcgagttgttccttcgctcgcgaccaagcgacaaggacactgagagctgcagtagcg gcggcggcagcagctctagcagcggtggcaaccaaccctcttctttcctcaggaacctcg accgcactcattgggaccaggttgtcttgtccgggagccatgtggctctccaccgccact ggctcccggtcagattcagagtccgaggaagaggacctccccgtcggggacgaagtctgc aaacgcggctacctgcggaaacagaagcatgggcacaggcgttacttcgtgctcaaactc gagaccgctgacgctccagctcgtctggaatactacgaaaatgctagaaagttccggcac agtgtccgcgctgcggcggccgctgcagcggcggccacctctggtacccccgtgcccgcg ctcatcccgccgcggcgggtgatcaccctgtatcaatgtttctccgtgagccagcgagct gatgcaaggtaccgacacctcattgcccttttcacccagaacgagtacttcgcgatggtg gccgagaacgagacagagcaagaaagctggtacttgctgctcagccgcctcatcctcgag agcaagcgccgccgctgcggcatgctgggcgcgcagccggacggagagccggctgcgctg gcggcggcagcggcggcggagccacccttctataaagatgtgtggcaggtagtaatcaaa ccgagggggctggggcacagaaaagagctgagcggtgtgttccggctgtgtcttaccgac gaagaggtcgtgtttgtgaggctgaacaccgaagtggccagcgtagtcgtccagctcctg agcatccgtcgctgcgggcactcagagcaatatttcttcttggaagtcggcaggtctact gttatcggtccaggggagctgtggatgcaggtcgatgattgtgtagttgcccaaaacatg cacgagttgtttctggagaagatgagagccttgtgtgcagacgaatacagagcccgctgc cgcagctacagcgtcaacattggcgcccacctgttaaccctgctgtccgctaggaggcac ctaggcttgctgccgctagagcccggcggctggctccgaaggtcccgcttcgagcagttt tgccacttcagggccattggtgacagggacgacgagatgctcttcgccaggcgcttcata gcacccagcgaacccgtgcctccctccagacgtggaaggctgcaggtgcccagaccacgc aggtccaggagagcgatttcagtgccagccagcttttttcgacgcttagcgcctagcccg gtacattccccgaaccctgaagaagcctccaaggacagagcttgtgaagccttggcctca ggccgtggaaattctagggggaaaggcaaagagggtcaggaaggaaacggaggtgactac atgcccatgaacaactggggctcaggaaatggccgggactcgggaggtggccagggctcc agtggccaaggttccagtagccagagctcaggacgaaaccagtgctccagcgggaggcaa ggatctggaagtggccagggctcaaatggtggccaaggatcaggaggtcagcgctcagga ggtcagggcgctagaggaaaccagtccccaggagatggccataacaccacaggtagccat ggctcaggcaatggccagggacctggaagtggccatggctcaggtggtagccagagaccc agagatggccatggctcaggtggtggcaagaactcaggagggagcaagggttcaggaagt gagaaaagtactgatggtgatggtgaccatgcaaaatctctgaagaaaagatcttatttt ggtaaatttactccaggcaaacaaccgcaaatggcacctcctccaccaccaccaccccca ccagctggagcaactaatggaaaagggaagtctggagggcgattccgactttatttttgt gctgacagaggacccacaaaagaacgcaaagacaccaaagagatgagagatacggagacc ccagaaggtgtagctcggggttcccacagagccagagcttttgatgaagatgaggatgac ccatatgtgccaatgaggccaggggtggctgcccctcttgcaagctccagtgattatatg ccaatggctcctcaaaatgtttctgcttcaaaacagcgccactctcgatcaccatttgaa gattcacgaggatatatgatgatgtttccccgagtgagcccatcatctgcccaaagtact ccaaaaggacctgatcctaataaagaggatgactcaaaggataacgatagtgatggtgac tacatgtttatggctccaggagctggtgcaattccaaaaagcccgagaaatcctcaaggt ggctcttcctccaaaagttggagttcctacttcttgctgcctaactcttttcagagctca cccttgggacagagtgaccacagtgagtatgtaccaatgttacctggaaaattcctgggg agggccctggataaagaaggttcctcaaactggggcctcaaagatggagcttcaaagcct tcacttgaggggtcattctcaaaggctggagatggtggatcaccttcaaagccttcagat gatgaacccccaaagaataaggctaaaagacctaaccagctgtcttttattacaaaagga aataaaatcaagcccaaaccacaaaagcccacacaaaagcagagagaagctgacagcttt agtggttatgtcaacattgacttcactaaaagagatagcagtatgccagccccctctgct cgaggactgtcacattcattgggcataattgctgaccctagacagtcagccttttctaat tacatgaatgttgaattcagagtgcaatttccaaatccagcaagtcacctctcagatctt ttaagagctatcccaggttccaatcccttatttctggagggtgctgggtggccacttctt cctcttcctcccagggctgcaggtagcaattctaatgtcgaagagggtgactacattgaa gtaattttcaacccagcaatgacaccggccgtgccttttgctgacagtgccattcgctat gatgctgaaacaggtcgaatctatgtggtcaacccattttctgagctctgtatggacatt tctctctcccctagcagacgctctgaaccaccacctgtagctaggctgctgcaggaagag caagataccagatgctctcaaagccgttcacaaagtttctttgcagctgtcagagcagct gtttcggctttcctgactgatggccaccagagagcgatttctgctgccccctcctcagct gcagcaccagcagaggcgccaaccttagcggtgggccgggggttagctgcggcatcagcg ctcgctgtagccccgggcttaggcgcagccgccgcgggcttagaggctgcggctgggttt gactccgcctctccccgcgggtttcaacctgttgctgatgctgctggtacagaggcagtt agggaggccctggacaatgcgggtggcgcgaatcctagaaccccgaacccacctgcagac cttgccagaggtgagaacgcagctggcggggctgccgccgcagctgagggtcccccacca cccccgcgccaccgctgggtgccgagacccccggagagagaagagtctgaagacgaagac gaaacttacgtgagaatggactttgccagacctgacaacaagaagttccactctccgaaa agagagtga

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