Harpia harpyja (harpy eagle): 128144955
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Entry
128144955 CDS
T10541
Symbol
HSD3B1
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
hhar Harpia harpyja (harpy eagle)
Pathway
hhar00140
Steroid hormone biosynthesis
hhar01100
Metabolic pathways
Module
hhar_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
hhar_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
hhar_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
hhar00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
128144955 (HSD3B1)
Enzymes [BR:
hhar01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
128144955 (HSD3B1)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
128144955 (HSD3B1)
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Motif
Pfam:
3Beta_HSD
Epimerase
GDP_Man_Dehyd
NAD_binding_4
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
NmrA
KR
Ldh_1_N
Motif
Other DBs
NCBI-GeneID:
128144955
NCBI-ProteinID:
XP_052650414
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Position
8:51307034..51318265
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AA seq
377 aa
AA seq
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MSLAGVSCLVTGAGGFLGQRIVRLLLEEEEALAEIRLLDKTFSNEALGRFGMFQGKTAVK
ILEGDIRDVTLLHRACQGVSVVIHTASIIDTLGLIEKQLLWEVNVTGTQLLLEACVHCNV
QHFIYTSTIEVTGPNCKGDPIFNGDEDTAYESISKSPYAQSKRLAEDSVLKADGQVLKDG
GTLMTCALRSMYIFGEGCPFLQGHLDKCLLNKNVYLRFSRKEAFVNPVYVGNIAWAHVQA
AKALQVPQKAKHIRGQFYYISDDTPYMSYADLNYELTRDLGFGIEPRLPMPLTMLYYFSL
LLEIVSFLLRPFVRYIPSTNRHLVTLLNTPFTFSYRKAQKDFGYMPRYTWEEAKQCTAQW
IASMVPQRREYLKSKAA
NT seq
1134 nt
NT seq
+upstream
nt +downstream
nt
atgtccctggctggggtaagctgcctggtgacaggagcaggaggatttcttggtcaaagg
attgtccgcttgctgttggaagaagaggaggcactggctgagatccgactgctagacaaa
acctttagcaatgaagcccttgggagatttggaatgttccagggtaagacagcagtgaaa
atcctggaaggggacatccgagatgtgacgttgctgcaccgtgcctgtcagggggtctcc
gttgtcatccacacggcttccatcattgacaccttgggcctcatagagaagcagctgctc
tgggaagtcaatgtaacaggtactcagctactgctggaggcatgtgtccattgtaacgtc
cagcacttcatatataccagtaccatagaagtgacaggcccaaactgcaaaggtgaccca
attttcaatggtgatgaagatacagcttatgagagtatatcaaaatctccttatgcccag
agtaagagactggcagaggattctgtgctgaaagcagatggccaggtgctaaaggatggt
ggcacgctgatgacctgcgccctgagatccatgtacatttttggagaaggttgcccgttt
cttcaaggtcatctggataagtgtctgttgaacaaaaatgtctacctgcgcttctccaga
aaggaggctttcgtgaaccccgtgtacgtggggaacatcgcctgggcacatgtgcaggca
gccaaagccctgcaagtcccgcagaaagccaagcacatcagggggcagttctactacatc
tcagatgacactccttatatgagctacgcagatctaaattacgagctgaccagggacctg
gggtttggaatcgagccccggctccccatgcctctgacaatgttgtattacttctcgcta
ctgctggagattgtgagcttcttgctccggccctttgtcagatacatcccctccaccaac
cgtcacctggtcactctattgaacaccccattcaccttctcttatagaaaagcacagaag
gattttggctacatgcctcgctacacgtgggaagaggccaagcagtgcactgctcagtgg
attgcctccatggtcccacagagaagggagtacttgaaaagcaaggctgcctaa
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