Hyaena hyaena (striped hyena): 120225093 Help Entry 120225093         CDS       T07257                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism hhv  Hyaena hyaena (striped hyena) Pathway hhv00230   Purine metabolism hhv01100   Metabolic pathways hhv01522   Endocrine resistance hhv04015   Rap1 signaling pathway hhv04020   Calcium signaling pathway hhv04022   cGMP-PKG signaling pathway hhv04024   cAMP signaling pathway hhv04062   Chemokine signaling pathway hhv04072   Phospholipase D signaling pathway hhv04081   Hormone signaling hhv04082   Neuroactive ligand signaling hhv04114   Oocyte meiosis hhv04211   Longevity regulating pathway hhv04213   Longevity regulating pathway - multiple species hhv04261   Adrenergic signaling in cardiomyocytes hhv04270   Vascular smooth muscle contraction hhv04371   Apelin signaling pathway hhv04540   Gap junction hhv04611   Platelet activation hhv04713   Circadian entrainment hhv04714   Thermogenesis hhv04723   Retrograde endocannabinoid signaling hhv04724   Glutamatergic synapse hhv04725   Cholinergic synapse hhv04727   GABAergic synapse hhv04750   Inflammatory mediator regulation of TRP channels hhv04911   Insulin secretion hhv04912   GnRH signaling pathway hhv04913   Ovarian steroidogenesis hhv04914   Progesterone-mediated oocyte maturation hhv04915   Estrogen signaling pathway hhv04916   Melanogenesis hhv04918   Thyroid hormone synthesis hhv04921   Oxytocin signaling pathway hhv04922   Glucagon signaling pathway hhv04923   Regulation of lipolysis in adipocytes hhv04925   Aldosterone synthesis and secretion hhv04926   Relaxin signaling pathway hhv04927   Cortisol synthesis and secretion hhv04928   Parathyroid hormone synthesis, secretion and action hhv04934   Cushing syndrome hhv04935   Growth hormone synthesis, secretion and action hhv04970   Salivary secretion hhv04971   Gastric acid secretion hhv04972   Pancreatic secretion hhv04976   Bile secretion hhv05032   Morphine addiction hhv05163   Human cytomegalovirus infection hhv05166   Human T-cell leukemia virus 1 infection hhv05200   Pathways in cancer hhv05207   Chemical carcinogenesis - receptor activation hhv05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hhv00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     120225093 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     120225093 (ADCY2)    04371 Apelin signaling pathway     120225093 (ADCY2)    04020 Calcium signaling pathway     120225093 (ADCY2)    04072 Phospholipase D signaling pathway     120225093 (ADCY2)    04024 cAMP signaling pathway     120225093 (ADCY2)    04022 cGMP-PKG signaling pathway     120225093 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     120225093 (ADCY2)    04081 Hormone signaling     120225093 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     120225093 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     120225093 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     120225093 (ADCY2)    04062 Chemokine signaling pathway     120225093 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     120225093 (ADCY2)    04922 Glucagon signaling pathway     120225093 (ADCY2)    04923 Regulation of lipolysis in adipocytes     120225093 (ADCY2)    04912 GnRH signaling pathway     120225093 (ADCY2)    04913 Ovarian steroidogenesis     120225093 (ADCY2)    04915 Estrogen signaling pathway     120225093 (ADCY2)    04914 Progesterone-mediated oocyte maturation     120225093 (ADCY2)    04921 Oxytocin signaling pathway     120225093 (ADCY2)    04926 Relaxin signaling pathway     120225093 (ADCY2)    04935 Growth hormone synthesis, secretion and action     120225093 (ADCY2)    04918 Thyroid hormone synthesis     120225093 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     120225093 (ADCY2)    04916 Melanogenesis     120225093 (ADCY2)    04925 Aldosterone synthesis and secretion     120225093 (ADCY2)    04927 Cortisol synthesis and secretion     120225093 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     120225093 (ADCY2)    04270 Vascular smooth muscle contraction     120225093 (ADCY2)   09154 Digestive system    04970 Salivary secretion     120225093 (ADCY2)    04971 Gastric acid secretion     120225093 (ADCY2)    04972 Pancreatic secretion     120225093 (ADCY2)    04976 Bile secretion     120225093 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     120225093 (ADCY2)    04727 GABAergic synapse     120225093 (ADCY2)    04725 Cholinergic synapse     120225093 (ADCY2)    04723 Retrograde endocannabinoid signaling     120225093 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     120225093 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     120225093 (ADCY2)    04213 Longevity regulating pathway - multiple species     120225093 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     120225093 (ADCY2)    04714 Thermogenesis     120225093 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     120225093 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     120225093 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     120225093 (ADCY2)    05163 Human cytomegalovirus infection     120225093 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     120225093 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     120225093 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     120225093 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     120225093 (ADCY2) Enzymes [BR:hhv01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      120225093 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N Motif Other DBs NCBI-GeneID:  120225093 NCBI-ProteinID:  XP_039079248 LinkDB All DBs Position Unknown AA seq 850 aa AA seqDB search ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPHLFRPRH TLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLR TKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFK YYVTCACLILFCIFIVQILVLPKTSILGISFGAAFLLLALILFVCFAGQLLQCSKKASSS LLWLLKSSSIIADRPWPRVSLTVLTTTIILTMAVFNMFFLSDPEKTIPPTANTSNTSLSA LSNQAAVLRAHNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMAALVGYNTILLHTH AHVLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKKE REEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKEFYT ESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQ EPERQYMHIGTMVEFAFAMVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIW GNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKTYFVNTEMS RSLSQSNLAS NT seq 2553 nt NT seq  +upstreamnt  +downstreamnt gagcggctcctgctctccctgttgccggctcacatagccatggaaatgaaagctgagatc atccagaggctgcagggccccaaagccggccaaatggaaaacacgaacaactttcacaac ctctatgtcaagcgacacacgaatgtgagtatcctgtacgcggacatcgttggcttcacc cggctggccagtgactgctccccaggagagctggtccacatgctgaacgagctctttgga aagttcgatcagattgcaaaggagaatgaatgcatgagaataaaaattttgggagactgc tactactgtgtgtccggactccccatatctctcccaaaccatgccaagaattgtgtgaaa atggggctggatatgtgtgaagccataaagaaagtgagggacgccaccggcgtggacatc aacatgcgcgtcggagtgcattctgggaacgtcctctgcggcgtgattggtctgcagaag tggcagtacgacgtgtggtcacatgacgttacgttggccaatcacatggaagctggcggg gtccctggacgtgttcacatttcttctgtcaccttggagcacttgaatggcgcttataaa gtggaggaaggagatggggatatcagagacccatatttaaaacagcacctggtgaaaacc tactttgtaatcaaccccaagggggaacggcggagtcctcacctcttcagacctcgccac accctcgatggagccaagatgagggcctccgtccgcatgacccggtacctggagtcctgg ggggccgccaagccctttgcgcacctgcatcaccgggacagcatgaccacggagaacggc aagatcagcaccacggatgtgccaatgggtcagcataatttccaaaatcgtaccttaaga accaagtcacaaaagaaaagatttgaagaagaattaaatgaaaggatgatccaagcaatt gatggaatcaatgcacaaaagcagtggctcaagtctgaagacattcagagaatctcgctt ctgttctacaataaagtactagaaaaggaataccgagccactgcactgccggcgttcaag tattatgtgacctgcgcgtgtcttatattgttctgcatcttcatcgtgcagattctggtg ttgcccaaaacgtccattctcgggatctcctttggagccgcgtttctcttgcttgcctta atccttttcgtctgctttgctggacagctattgcaatgcagcaagaaggcctcctcctct ctgctgtggctgctgaagtcgtccagcatcattgccgaccggccctggccacgggtctcc ctcacggtccttaccaccaccatcatcctgaccatggccgtgttcaacatgtttttcctg agcgacccagagaaaacaattcctccaactgccaatacatcaaacacaagtctctctgcc ttaagtaatcaggcagcagttctgcgcgcacacaatttgtttttcctcccgtactttatc tacagctgcattctgggactgatttcctgctcggttttcctgcgggtgaattacgagttg aagatgctgatcatgatggcggcattggtaggctacaacaccatccttctccacactcac gcccacgtcctggacgactacagccaggtcttattcgagagaccaggcatttggaaagac ctgaagaccatgggctcagtgtctctctttatattcttcatcacactgctcgttctgggt cgacagaatgaatattactgtaggttagacttcctgtggaagaacaagttcaaaaaagag cgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggagaacgtgctgcct gcgcacgtggccgagcatttcctggcccggagcctgaagaacgaggacttataccaccag tcctatgactgcgtctgcgtcatgttcgcctccattccggatttcaaggagttctacaca gagtcagatgtgaacaaggagggcttggaatgccttcggctcctgaatgagatcatcgcc gactttgatgatctgctgtccaagccgaagtttagcggggttgaaaagatcaagaccatt ggcagcacgtatatggcagcaaccggtctgagcgccgtgcccagccaggagcacgcccag gagcccgagaggcagtacatgcacatcggcaccatggtggagtttgcctttgccatggtg gcgaagctggacgctatcaacaagcactccttcaatgacttcaagctgcgagtgggtatt aaccacggacctgtgatagccggtgtgattggagctcagaagccacagtacgacatctgg ggcaacaccgtgaacgtggccagcaggatggatagcaccggcgtgctggacaaaatacag gtcaccgaggagacaagcctcatccttcagacgctggggtacacgtgcacatgtcgggga ataatcaacgtgaaaggcaagggggagctgaagacgtactttgtaaacacagaaatgtca aggtcactttcccagagcaacttggcttcttga

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