Hyaena hyaena (striped hyena): 120228369 Help Entry 120228369         CDS       T07257                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism hhv  Hyaena hyaena (striped hyena) Pathway hhv04022   cGMP-PKG signaling pathway hhv04068   FoxO signaling pathway hhv04081   Hormone signaling hhv04140   Autophagy - animal hhv04152   AMPK signaling pathway hhv04211   Longevity regulating pathway hhv04213   Longevity regulating pathway - multiple species hhv04910   Insulin signaling pathway hhv04920   Adipocytokine signaling pathway hhv04923   Regulation of lipolysis in adipocytes hhv04930   Type II diabetes mellitus hhv04931   Insulin resistance hhv04932   Non-alcoholic fatty liver disease hhv04935   Growth hormone synthesis, secretion and action hhv05010   Alzheimer disease hhv05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:hhv00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     120228369 (IRS2)    04022 cGMP-PKG signaling pathway     120228369 (IRS2)    04152 AMPK signaling pathway     120228369 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     120228369 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     120228369 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     120228369 (IRS2)    04923 Regulation of lipolysis in adipocytes     120228369 (IRS2)    04920 Adipocytokine signaling pathway     120228369 (IRS2)    04935 Growth hormone synthesis, secretion and action     120228369 (IRS2)   09149 Aging    04211 Longevity regulating pathway     120228369 (IRS2)    04213 Longevity regulating pathway - multiple species     120228369 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     120228369 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     120228369 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     120228369 (IRS2)    04932 Non-alcoholic fatty liver disease     120228369 (IRS2)    04931 Insulin resistance     120228369 (IRS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  120228369 NCBI-ProteinID:  XP_039082621 LinkDB All DBs Position Unknown AA seq 1270 aa AA seqDB search MASPPPPGPPAPAGGDGPNLNNNNNNNNHGVRKCGYLRKQKHGHKRFFVLRGPGDEAAAA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTRDEYF AVAAENEHEQDGWYRALTELVSEGRAPPAAAPPAAAPCSASLPGALGGSAGAAAAEDGDG PPAPAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRC GHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQS SGSSSTHPISVPGARRHHHLVHLPPSQTGLVRRSRTDSLAATPPAAKCGSCRVRTASEGD GGAAAGAAGGRPVSVAGSPLSPGPLRAPLSRSHTLSGGCGGRASKVAPAPAGGALQHSRS MSMPVARSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLPLQQPAGQRPSSGSASASGSP SDPGFMSLDEYGSSPGDLRAFCGHRSTTPESVAETPPARDGGGSELYGYMTMDRALGHGG RPYRRVSGDAAPDLDRGLRKRTYSLTTPARQRPAPQPSSASLDEYTLTRVAFSGSSGRPC PACPAASPRGAYHPYPEDYGDIEIGSHRSSSSNSGADDGYVPMTPGGALAGGGCRSDDYM PMSPTSVSAPKQILQPRAGAPAAPPAAAAGPAPAPGRPFPAAGGGCKAGSPAESSPEDSG YMRMWCGSRLSVESGDGKLLANGDYLNMSPSDAGAPGTPPDFFPAALQGGPGCCAGPLPR SCKAPYACAGDNDQYVLMSSPVGRIPEERPAPPPSPGASGHARPPHPVVPSPPRPGGGAG GFLGPRCRAVRPTRLSLEGLHTLPSMHELPLPPEPRSPGEYINIDFGEAGARLSPPAPPL LAAGSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPGGDPVGSLDALLSP EAAAPYPPLPPRPAAPASSLQPPPPPPGELYRRPPAPPAPGPSAASPSSPEAADNGDYTE MAFGVAATPPQPIAAPPKPDGARVASPASGVKRLSLMEQVSGVEAFLQAAQPPDPHRGAK VIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGGGGGL AGGEERPTSPRQAQPPPPQQARPWLPGQPGALAAGSPMRRETSAGFQNGLNYIAIDVRDE AGPHPQPQPGEKGAWGRTHSLGGLISAAVGGSGAGGVCGGPGPGALPSASTYASIDFLSH HLKEATIVKE NT seq 3813 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgccgcccgggccccccgcgccggcgggcggcgacggccccaacctc aacaacaacaacaacaacaacaaccacggcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgacgaggcggcggccgcg ggcggggggccggcgccgcagccgccgcggctcgagtactacgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctcaacatcaac aagcgcgccgacgccaagcacaagtacctgatcgcgctctacacccgcgacgagtacttc gccgtggcggccgagaacgagcacgagcaggacggctggtaccgcgcgctcaccgagctg gtgagcgagggccgcgcgccccccgccgccgcgccccccgccgccgcgccctgcagcgcc tccctgcccggcgccctgggcggctcggccggcgccgccgcggccgaggacggcgacggg ccgccggcgcccgcctaccgcgaggtgtggcaggtgaacctgaagcccaagggcctgggc cagagcaagaacctgacgggcgtgtaccgcctgtgcctgtcggcgcgcaccatcggcttc gtgaagctcaactgcgagcagccgtcggtgacgctgcagctcatgaacatccgccgctgc ggccactcggacagcttcttcttcatcgaggtggggcgctcggccgtcacgggcccgggc gagctgtggatgcaggccgacgactcggtggtggcgcagaacatccacgagaccatcctg gaggccatgaaggcgctcaaggagctcttcgagttccggccgcgcagcaagagccagtcg tcgggctcgtcgtccacccaccccatcagcgtccccggcgcgcgccgccaccaccacctg gtccacctgccgcccagccagacgggcctggtgcgccgctcgcgcaccgacagcctggcc gccaccccgccggccgccaagtgcggctcgtgccgggtgcgcacggccagcgagggcgac ggcggcgcggcggccggggcggcgggcggcaggcccgtgtcggtggccgggagtcccctg agccccgggccgctgcgcgcgcccctgagccgctcgcacaccctgagcggcggctgcggc gggcgcgcgagcaaggtggcgccggcgccggcagggggcgccctgcagcacagccgctcc atgtccatgcccgtggcgcgctcgccgcccgcggccaccagccccggcagcctgtcgtcc agcagcgggcacggctccgggtcctacccgccgcccccgggcccgcacccgcacctcccc ctgcagcagcccgccggccagcggccctccagcggcagcgcctcggcctcgggctccccc agcgaccccggcttcatgtccctggacgagtacggctccagccccggcgacctgcgggcc ttctgcggccacaggagcaccacgcccgagtccgtcgccgagacgcccccggcccgggac ggcggcgggagcgagctgtacgggtacatgaccatggaccgggcgctgggccacggcggc cgcccctaccgccgggtgtcgggggacgcggcgccggacctggaccgggggctgcgcaag aggacttactcgctgaccacgcccgcgcggcagcggccggcgccccagccctcctccgcg tcgctggatgagtacacgctgacgcgggtggccttctcgggcagctcgggccgcccctgc ccggcctgccccgccgcgtccccccgaggggcttaccacccctaccccgaggactacggg gacatcgagatcgggtcgcacaggagctccagcagcaactcgggggccgacgacggctac gtgcccatgacccccggcggggcgctcgcgggcggcggctgcaggagcgacgactacatg cccatgagccccaccagcgtgtcggccccgaagcagatcctgcagccccgcgccggcgcc cccgccgcgccgcccgcggcagccgcggggcccgcgcccgcgccgggcaggcccttcccg gccgcggggggcggctgcaaggcgggctccccggccgagagctcgcccgaggacagcggc tacatgcgcatgtggtgcggctccaggctgtcggtggagagcggcgacggcaagctgctg gccaacggggactacctcaacatgtcccccagcgacgcgggcgccccggggacgcccccc gacttcttccccgccgccttgcagggcgggcccggctgctgcgccggccccttgccgcgc tcctgcaaggcgccctacgcctgtgccggcgacaacgaccagtacgtgctcatgagctcg cccgtggggcgcatcccggaggagaggccggcgccgccccccagcccgggcgccagcggc cacgcgcggcccccgcaccccgtcgtgccttcgcccccgcggccgggcggcggcgccggc ggcttcctgggcccgcgctgccgggccgtgcggcccacgcgcctgtcgctcgaggggctg cacaccctgcccagcatgcacgagctcccgctgccgcccgagccccggagccccggcgag tacatcaacatcgacttcggcgaggcgggggcgcgcctgtcgccgcccgcgcccccgctg ctggccgccggcagcccggcctcctcgctgggctcgggcaccccgggcaccagcagcgac agcaggcagcgctccccgctgtccgactacatgaacctcgacttcagctcgcccaagtcg cccaagccgggcgccccgggcggggaccccgtgggctccctggacgccctcctgtccccc gaggccgccgccccctacccgcccctgcccccgcgccccgccgcgcccgcctcgtcgctg cagccgccgccgcccccgcccggggagctgtaccgccggccccccgcgccccctgccccg ggccccagcgccgcctccccttcgtcccccgaggccgcggacaacggggactacaccgag atggccttcggcgtggccgccaccccgccgcagcccatcgccgcgcccccgaagccggac ggcgcccgcgtcgccagccccgcgtcgggcgtcaagcggctgagcctcatggagcaggtg tcgggcgtggaggccttcctgcaggccgcgcagcccccggacccgcacaggggcgccaag gtcatccgcgcggacccgcagggcggccgccgccgccacagctccgagaccttctcctcg accaccactgtgacccccgtgtccccgtccttcgcccacaacccgaagcgccacaactcg gcctccgtggaaaacgtctctctcaggaaaagcagcgaaggcggcggcggcggcggcctg gccgggggcgaggagcgccccacgtccccgcgccaggcgcagcccccgccgccccagcag gccaggccgtggctgccgggtcagccgggggccttggccgcgggctccccgatgcgcagg gagacgtccgccggcttccagaacggcctcaactacatcgccatcgacgtgagggacgag gccgggccgcacccgcagccgcagccgggggagaagggcgcctggggccggacccatagc ctcgggggcctcatcagcgccgccgtggggggcagcggcgccggcggcgtgtgtgggggc ccgggccctggcgccctgccctccgccagcacctacgccagcattgacttcctgtcgcat cacctgaaggaggccaccatcgtgaaagagtga

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