Hylobates moloch (silvery gibbon): 116469522
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Entry
116469522 CDS
T08803
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
hmh
Hylobates moloch (silvery gibbon)
Pathway
hmh00140
Steroid hormone biosynthesis
hmh01100
Metabolic pathways
hmh04913
Ovarian steroidogenesis
hmh04925
Aldosterone synthesis and secretion
hmh04927
Cortisol synthesis and secretion
hmh04934
Cushing syndrome
Module
hmh_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
hmh_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
hmh_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hmh_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
hmh00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
116469522
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
116469522
04925 Aldosterone synthesis and secretion
116469522
04927 Cortisol synthesis and secretion
116469522
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
116469522
Enzymes [BR:
hmh01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
116469522
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
116469522
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Paralog
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Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
KR
NmrA
Ldh_1_N
Sacchrp_dh_NADP
Ilm1
Semialdhyde_dh
Motif
Other DBs
NCBI-GeneID:
116469522
NCBI-ProteinID:
XP_032010743
LinkDB
All DBs
Position
Unknown
AA seq
375 aa
AA seq
DB search
MAMTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFRPELREEFSKLQNKTKLTV
LEGDILDEPFLKRACQDISVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVP
VFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPYSKKLAEKAVLAANGWTLKNGG
TLYTCALRPMYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALR
ALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSLPLSLMYWIGFLL
EIVSFLLRPLYTYRPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVG
SLVDRHKETLKSKTQ
NT seq
1128 nt
NT seq
+upstream
nt +downstream
nt
atggccatgacaggctggagctgccttgtgacaggagcaggagggtttctgggacagagg
atcatccgcctcttggtgaaggagaaggagctgaaggagatcagggtcttggacaaggcc
ttcagaccagaactgagggaggaattttctaagctccagaacaagaccaagctgacagtg
ctggaaggagacattctggatgagccattcctgaagagagcctgccaggatatctcggtc
gtcatccacaccgcctgtatcattgatgtcttcggtgtcactcacagagagtctatcatg
aatgtcaatgtgaaaggtacccagctcctgttagaggcctgtgtccaagctagtgtgcca
gtcttcatctacaccagtagcatagaggtagccgggcccaactcctacaaggaaatcatc
cagaacggccacgaagaagagcctctggaaaacacatggcccgctccatatccatacagc
aaaaagcttgctgagaaggctgtgctggcggctaatgggtggactctgaaaaacggcggc
accttgtacacttgtgccttacgacccatgtatatctatggggaaggaggcccattcctt
tctgctagtataaatgaggccctgaacaacaatgggatcctgtcaagtgttggaaagttc
tccactgttaacccagtctatgttggcaacgtggcctgggcccacattctggccttgagg
gccctgcaggaccccaagaaggccccaagcatccgaggacagttctactatatctcagat
gacacgcctcaccaaagctatgataaccttaattacaccctgagcaaagagttcggcctc
cgccttgattccagatggagccttcctttatccctgatgtactggattggcttcctgctg
gaaatagtgagtttcctactcaggccactttatacctatcgaccgcccttcaaccgccac
acagtcacattatcaaatagcgtattcactttctcttataagaaggctcagcgagatctg
gcgtataagccactctacagctgggaggaagccaagcagaaaactgtggagtgggttggt
tcccttgtggatcggcacaaggagaccctgaagtccaagactcagtga
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