Homo sapiens (human): 4317
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Entry
4317 CDS
T01001
Symbol
MMP8, CLG1, HNC, MMP-8, PMNL-CL
Name
(RefSeq) matrix metallopeptidase 8
KO
K01402
matrix metalloproteinase-8 (neutrophil collagenase) [EC:
3.4.24.34
]
Organism
hsa
Homo sapiens (human)
Drug target
Cipemastat:
D03517
Rebimastat:
D03800
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4317 (MMP8)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.34 neutrophil collagenase
4317 (MMP8)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M10
4317 (MMP8)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M10
Hemopexin
PG_binding_1
Reprolysin_3
Reprolysin_5
Reprolysin_4
DUF4953
Motif
Other DBs
NCBI-GeneID:
4317
NCBI-ProteinID:
NP_002415
OMIM:
120355
HGNC:
7175
Ensembl:
ENSG00000118113
UniProt:
P22894
Structure
PDB
PDBj
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All DBs
Position
11:complement(102711796..102724954)
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AA seq
467 aa
AA seq
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MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
NT seq
1404 nt
NT seq
+upstream
nt +downstream
nt
atgttctccctgaagacgcttccatttctgctcttactccatgtgcagatttccaaggcc
tttcctgtatcttctaaagagaaaaatacaaaaactgttcaggactacctggaaaagttc
taccaattaccaagcaaccagtatcagtctacaaggaagaatggcactaatgtgatcgtt
gaaaagcttaaagaaatgcagcgattttttgggttgaatgtgacggggaagccaaatgag
gaaactctggacatgatgaaaaagcctcgctgtggagtgcctgacagtggtggttttatg
ttaaccccaggaaaccccaagtgggaacgcactaacttgacctacaggattcgaaactat
accccacagctgtcagaggctgaggtagaaagagctatcaaggatgcctttgaactctgg
agtgttgcatcacctctcatcttcaccaggatctcacagggagaggcagatatcaacatt
gctttttaccaaagagatcacggtgacaattctccatttgatggacccaatggaatcctt
gctcatgcctttcagccaggccaaggtattggaggagatgctcattttgatgccgaagaa
acatggaccaacacctccgcaaattacaacttgtttcttgttgctgctcatgaatttggc
cattctttggggctcgctcactcctctgaccctggtgccttgatgtatcccaactatgct
ttcagggaaaccagcaactactcactccctcaagatgacatcgatggcattcaggccatc
tatggactttcaagcaaccctatccaacctactggaccaagcacacccaaaccctgtgac
cccagtttgacatttgatgctatcaccacactccgtggagaaatacttttctttaaagac
aggtacttctggagaaggcatcctcagctacaaagagtcgaaatgaattttatttctcta
ttctggccatcccttccaactggtatacaggctgcttatgaagattttgacagagacctc
attttcctatttaaaggcaaccaatactgggctctgagtggctatgatattctgcaaggt
tatcccaaggatatatcaaactatggcttccccagcagcgtccaagcaattgacgcagct
gttttctacagaagtaaaacatacttctttgtaaatgaccaattctggagatatgataac
caaagacaattcatggagccaggttatcccaaaagcatatcaggtgcctttccaggaata
gagagtaaagttgatgcagttttccagcaagaacatttcttccatgtcttcagtggacca
agatattacgcatttgatcttattgctcagagagttaccagagttgcaagaggcaataaa
tggcttaactgtagatatggctga
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