Homo sapiens (human): 10054
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Entry
10054 CDS
T01001
Symbol
UBA2, ACCES, ARX, HRIHFB2115, SAE2
Name
(RefSeq) ubiquitin like modifier activating enzyme 2
KO
K10685
ubiquitin-like 1-activating enzyme E1 B [EC:
6.2.1.45
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
Disease
H02758
ACCES syndrome
Drug target
Subasumstat:
D12268
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
10054 (UBA2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
10054 (UBA2)
Enzymes [BR:
hsa01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.45 E1 ubiquitin-activating enzyme
10054 (UBA2)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin-activating enzymes (E1)
UBL-activating enzymes
10054 (UBA2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ThiF
UAE_UbL
UBA2_C
UBA_E1_SCCH
NAD_binding_7
Motif
Other DBs
NCBI-GeneID:
10054
NCBI-ProteinID:
NP_005490
OMIM:
613295
HGNC:
30661
Ensembl:
ENSG00000126261
UniProt:
Q9UBT2
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:34428381..34471251
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AA seq
640 aa
AA seq
DB search
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
NT seq
1923 nt
NT seq
+upstream
nt +downstream
nt
atggcactgtcgcgggggctgccccgggagctggctgaggcggtggccgggggccgggtg
ctggtggtgggggcgggcggcatcggctgcgagctcctcaagaatctcgtgctcaccggt
ttctcccacatcgacctgattgatctggatactattgatgtaagcaacctcaacagacag
tttttgtttcaaaagaaacatgttggaagatcaaaggcacaggttgccaaggaaagtgta
ctgcagttttacccgaaagctaatatcgttgcctaccatgacagcatcatgaaccctgac
tataatgtggaatttttccgacagtttatactggttatgaatgctttagataacagagct
gcccgaaaccatgttaatagaatgtgcctggcagctgatgttcctcttattgaaagtgga
acagctgggtatcttggacaagtaactactatcaaaaagggtgtgaccgagtgttatgag
tgtcatcctaagccgacccagagaacctttcctggctgtacaattcgtaacacaccttca
gaacctatacattgcatcgtttgggcaaagtacttgttcaaccagttgtttggggaagaa
gatgctgatcaagaagtatctcctgacagagctgaccctgaagctgcctgggaaccaacg
gaagccgaagccagagctagagcatctaatgaagatggtgacattaaacgtatttctact
aaggaatgggctaaatcaactggatatgatccagttaaactttttaccaagctttttaaa
gatgacatcaggtatctgttgacaatggacaaactatggcggaaaaggaaacctccagtt
ccgttggactgggctgaagtacaaagtcaaggagaagaaacgaatgcatcagatcaacag
aatgaaccccagttaggcctgaaagaccagcaggttctagatgtaaagagctatgcacgt
cttttttcaaagagcatcgagactttgagagttcatttagcagaaaagggggatggagct
gagctcatatgggataaggatgacccatctgcaatggattttgtcacctctgctgcaaac
ctcaggatgcatattttcagtatgaatatgaagagtagatttgatatcaaatcaatggca
gggaacattattcctgctattgctactactaatgcagtaattgctgggttgatagtattg
gaaggattgaagattttatcaggaaaaatagaccagtgcagaacaatttttttgaataaa
caaccaaacccaagaaagaagcttcttgtgccttgtgcactggatcctcccaaccccaat
tgttatgtatgtgccagcaagccagaggtgactgtgcggctgaatgtccataaagtgact
gttctcaccttacaagacaagatagtgaaagaaaaatttgctatggtagcaccagatgtc
caaattgaagatgggaaaggaacaatcctaatatcttccgaagagggagagacggaagct
aataatcacaagaagttgtcagaatttggaattagaaatggcagccggcttcaagcagat
gacttcctccaggactatactttattgatcaacatccttcatagtgaagacctaggaaag
gacgttgaatttgaagttgttggtgatgccccggaaaaagtggggcccaaacaagctgaa
gatgctgccaaaagcataaccaatggcagtgatgatggagctcagccctccacctccaca
gctcaagagcaagatgacgttctcatagttgattcagatgaagaagattcttcaaataat
gccgacgtcagtgaagaagagagaagccgcaagaggaaattagatgagaaagagaatctc
agtgcaaagaggtcacgtatagaacagaaggaagagcttgatgatgtcatagcattagat
tga
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integrated database retrieval system
