Homo sapiens (human): 10352
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Entry
10352 CDS
T01001
Symbol
WARS2, NEMMLAS, PKDYS3, TrpRS, mtTrpRS
Name
(RefSeq) tryptophanyl tRNA synthetase 2, mitochondrial
KO
K01867
tryptophanyl-tRNA synthetase [EC:
6.1.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H02676
Infantile-onset parkinsonism-dystonia
H02709
Neurodevelopmental disorder with aminoacyl-tRNA synthetase defect
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
10352 (WARS2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
10352 (WARS2)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
10352 (WARS2)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.2 tryptophan---tRNA ligase
10352 (WARS2)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class I (G)
10352 (WARS2)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Other AARSs
10352 (WARS2)
Prokaryotic type
10352 (WARS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_1b
DUF2067
DUF4164
SgrT
Motif
Other DBs
NCBI-GeneID:
10352
NCBI-ProteinID:
NP_056651
OMIM:
604733
HGNC:
12730
Ensembl:
ENSG00000116874
UniProt:
Q9UGM6
Structure
PDB
PDBj
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All DBs
Position
1:complement(119031216..119140672)
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AA seq
360 aa
AA seq
DB search
MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWV
RLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEH
TQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGE
DQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI
TDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA
RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL
NT seq
1083 nt
NT seq
+upstream
nt +downstream
nt
atggcgctgcactcaatgcggaaagcgcgtgagcgctggagcttcatccgggcacttcat
aagggatccgcagctgctcccgctctccagaaagacagcaagaagcgagtattttccggc
attcaacctacaggaatcctccacctgggcaattacctgggagccattgagagctgggtg
aggttacaggatgaatatgactctgtattatacagcattgttgacctccactccattact
gtcccccaagacccagctgtccttcggcagagcatcctggacatgactgctgttcttctt
gcctgtggcataaacccggaaaaaagcatccttttccaacaatctcaggtgtctgaacac
acacaattaagttggatcctttcctgcatggtcagactacctcgattacaacatttacat
cagtggaaggcaaagactaccaagcagaagcacgatggcacggtgggcctgctcacatac
ccagtactccaggcagccgacattctgttgtacaagtccacacacgttcctgttggggag
gatcaagtccagcacatggaactagttcaggatctagcacaaggtttcaacaagaagtat
ggggagttctttccagtgcccgagtccattctcacatccatgaagaaggtaaaatcccta
cgtgatccttctgccaaaatgtcgaaatcagaccctgacaaactggccaccgtccgaata
acagacagcccagaggagatagtgcagaaattccgcaaggctgtgacagacttcacctcg
gaggtcacctatgacccggctggccgcgctggcgtgtccaacatagtggcggtgcatgcc
gcggtgacggggctctccgtggaggaagtggtgcgccgcagcgcgggcatgaacactgct
cgctacaagctggccgtggcagatgctgtgattgagaagtttgccccaattaagcgtgaa
attgaaaaactgaagctggacaaggaccatttagagaaggttttacaaattggatcagca
aaagccaaagaattagcatacactgtgtgccaggaggtgaagaaattggtgggttttcta
tag
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