KEGG   Homo sapiens (human): 10755
Entry
10755             CDS       T01001                                 
Symbol
GIPC1, C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, OPDM2, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2
Name
(RefSeq) GIPC PDZ domain containing family member 1
  KO
K20056  PDZ domain-containing protein GIPC
Organism
hsa  Homo sapiens (human)
Network
nt06541  Cytoskeleton in neurons
  Element
N01852  MYO6-mediated vesicle transport
Disease
H02513  Oculopharyngodistal myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10755 (GIPC1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    10755 (GIPC1)
SSDB
Motif
Pfam: GIPC1_GH1 GIPC1_GH2 PDZ PDZ_6 DDR PyrI
Other DBs
NCBI-GeneID: 10755
NCBI-ProteinID: NP_005707
OMIM: 605072
HGNC: 1226
Ensembl: ENSG00000123159
UniProt: O14908
LinkDB
Position
19:complement(14477762..14496127)
AA seq 333 aa
MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVF
HTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLE
DFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEA
INGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGR
GTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDEL
AEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY
NT seq 1002 nt   +upstreamnt  +downstreamnt
atgccgctgggactggggcggcggaaaaaggcgccccctctagtggaaaatgaggaggct
gagccaggccgtggagggctgggcgtgggggagccagggcctctgggcggaggtgggtcg
gggggcccccaaatgggcttgcccccccctcccccagccctgcggccccgcctcgtgttc
cacacccagctggcccatggcagtcccactggccgcatcgagggcttcaccaacgtcaag
gagctgtatggcaagatcgccgaggccttccgcctgccaactgccgaggtgatgttctgc
accctgaacacccacaaagtggacatggacaagctcctggggggccagatcgggctggag
gacttcatcttcgcccacgtgaaggggcagcgcaaggaggtggaggtgttcaagtcggag
gatgcactcgggctcaccatcacggacaacggggctggctacgccttcatcaagcgcatc
aaggagggcagcgtgatcgaccacatccacctcatcagcgtgggcgacatgatcgaggcc
attaacgggcagagcctgctgggctgccggcactacgaggtggcccggctgctcaaggag
ctgccccgaggccgtaccttcacgctgaagctcacggagcctcgcaaggccttcgacatg
atcagccagcgttcagcgggtggccgccctggctctggcccacaactgggcactggccga
gggaccctgcggctccgatcccggggccccgccacggtggaggatctgccctctgccttt
gaagagaaggccattgagaaggtggatgacctgctggagagttacatgggtatcagggac
acggagctggcggccaccatggtggagctgggaaaggacaaaaggaacccggatgagctg
gccgaggccctggacgaacggctgggtgactttgccttccctgacgagttcgtctttgac
gtctggggcgccattggggacgccaaggtcggccgctactag

KEGG   Homo sapiens (human): 1739
Entry
1739              CDS       T01001                                 
Symbol
DLG1, DLGH1, SAP-97, SAP97, hdlg
Name
(RefSeq) discs large MAGUK scaffold protein 1
  KO
K12076  disks large protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04390  Hippo signaling pathway
hsa04530  Tight junction
hsa04660  T cell receptor signaling pathway
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06166  Human papillomavirus (HPV)
nt06214  PI3K signaling (cancer)
nt06541  Cytoskeleton in neurons
  Element
N00340  The Scribble/Dlg/Lgl polarity module
N00341  HPV E6 to the Scribble/Dlg/Lgl polarity module
N00502  HTLV-1 Tax to PTEN-PIP3-AKT signaling pathway
N01852  MYO6-mediated vesicle transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    1739 (DLG1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    1739 (DLG1)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    1739 (DLG1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    1739 (DLG1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1739 (DLG1)
   05165 Human papillomavirus infection
    1739 (DLG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    1739 (DLG1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    1739 (DLG1)
SSDB
Motif
Pfam: Guanylate_kin PDZ MAGUK_N_PEST L27_1 PDZ_assoc PDZ_6 PDZ_2 SH3_1 SH3_2 SH3_9
Other DBs
NCBI-GeneID: 1739
NCBI-ProteinID: NP_001091894
OMIM: 601014
HGNC: 2900
Ensembl: ENSG00000075711
UniProt: Q12959
Structure
LinkDB
Position
3:complement(197042560..197299321)
AA seq 904 aa
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL
LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG
GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH
KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT
NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT
IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL
PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE
AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME
MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA
KEKL
NT seq 2715 nt   +upstreamnt  +downstreamnt
atgccggtccggaagcaagatacccagagagcattgcaccttttggaggaatatcgttca
aaactaagccaaactgaagacagacagctcagaagttccatagaacgggttattaacata
tttcagagcaacctctttcaggctttaatagatattcaagaattttatgaagtgacctta
ctggataatccaaaatgtatagatcgttcaaagccgtctgaaccaattcaacctgtgaat
acttgggagatttccagccttccaagctctactgtgacttcagagacactgccaagcagc
cttagccctagtgtagagaaatacaggtatcaggatgaagatacacctcctcaagagcat
atttccccacaaatcacaaatgaagtgataggtccagaattggttcatgtctcagagaag
aacttatcagagattgagaatgtccatggatttgtttctcattctcatatttcaccaata
aagccaacagaagctgttcttccctctcctcccactgtccctgtgatccctgtcctgcca
gtccctgctgagaatactgtcatcctacccaccataccacaggcaaatcctcccccagta
ctggtcaacacagatagcttggaaacaccaacttacgttaatggcacagatgcagattat
gaatatgaagaaatcacacttgaaaggggaaattcagggcttggtttcagcattgcagga
ggtacggacaacccacacattggagatgactcaagtattttcattaccaaaattatcaca
gggggagcagccgcccaagatggaagattgcgggtcaatgactgtatattacgagtaaat
gaagtagatgttcgtgatgtaacacatagcaaagcagttgaagcgttgaaagaagcaggg
tctattgtacgcttgtatgtaaaaagaaggaaaccagtgtcagaaaaaataatggaaata
aagctcattaaaggtcctaaaggtcttgggtttagcattgctggaggtgttggaaatcag
catattcctggggataatagcatctatgtaaccaaaataattgaaggaggtgcagcacat
aaggatggcaaacttcagattggagataaacttttagcagtgaataacgtatgtttagaa
gaagttactcatgaagaagcagtaactgccttaaagaacacatctgattttgtttatttg
aaagtggcaaaacccacaagtatgtatatgaatgatggctatgcaccacctgatatcacc
aactcttcttctcagcctgttgataaccatgttagcccatcttccttcttgggccagaca
ccagcatctccagccagatactccccagtttctaaagcagtacttggagatgatgaaatt
acaagggaacctagaaaagttgttcttcatcgtggctcaacgggccttggtttcaacatt
gtaggaggagaagatggagaaggaatatttatttcctttatcttagccggaggacctgct
gatctaagtggagagctcagaaaaggagatcgtattatatcggtaaacagtgttgacctc
agagctgctagtcatgagcaggcagcagctgcattgaaaaatgctggccaggctgtcaca
attgttgcacaatatcgacctgaagaatacagtcgttttgaagctaaaatacatgattta
cgggagcagatgatgaatagtagtattagttcagggtcaggttctcttcgaactagccag
aagcgatccctctatgtcagagccctttttgattatgacaagactaaagacagtgggctt
cccagtcagggactgaacttcaaatttggagatatcctccatgttattaatgcttctgat
gatgaatggtggcaagccaggcaggttacaccagatggtgagagcgatgaggtcggagtg
attcccagtaaacgcagagttgagaagaaagaacgagcccgattaaaaacagtgaaattc
aattctaaaacgagagataaaggggagatccctgacgacatgggatcaaaaggcctgaag
catgtaacttctaatgccagcgatagtgaaagtagttaccgtggtcaagaagaatacgtc
ttatcttatgaaccagtgaatcaacaagaagttaattatactcgaccagtgatcatattg
ggacctatgaaagacaggataaatgatgacttgatctcagaatttcctgacaaatttgga
tcctgtgttcctcatacaactagaccaaaacgagattatgaggtagatggaagagattat
cattttgtgacttcaagagagcagatggaaaaagatatccaggaacataaattcattgaa
gctggccagtataacaatcatctatatggaacaagtgttcagtctgtacgagaagtagca
gaaaagggcaaacactgtatccttgatgtgtctggaaatgccataaagagattacagatt
gcacagctttaccctatctccatttttattaaacccaaatccatggaaaatatcatggaa
atgaataagcgtctaacagaagaacaagccagaaaaacatttgagagagccatgaaactg
gaacaggagtttactgaacatttcacagctattgtacagggggatacgctggaagacatt
tacaaccaagtgaaacagatcatagaagaacaatctggttcttacatctgggttccggca
aaagaaaagctatga

KEGG   Homo sapiens (human): 1601
Entry
1601              CDS       T01001                                 
Symbol
DAB2, DOC-2, DOC2
Name
(RefSeq) DAB adaptor protein 2
  KO
K12475  disabled homolog 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Network
nt06541  Cytoskeleton in neurons
  Element
N01852  MYO6-mediated vesicle transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    1601 (DAB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1601 (DAB2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    1601 (DAB2)
SSDB
Motif
Pfam: DAB2_SBM PID Ntox17
Other DBs
NCBI-GeneID: 1601
NCBI-ProteinID: NP_001334
OMIM: 601236
HGNC: 2662
Ensembl: ENSG00000153071
UniProt: P98082 B2RAW0
Structure
LinkDB
Position
5:complement(39371677..39424980)
AA seq 770 aa
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDV
PDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNK
ISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKK
KIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLN
SEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPF
TQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQ
AGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSV
QSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQ
PNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGF
SQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFP
APAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQL
RQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPR
QVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
NT seq 2313 nt   +upstreamnt  +downstreamnt
atgtctaacgaagtagaaacaagtgcaaccaatggtcagcccgaccaacaggccgcacca
aaagcaccctcaaagaaggaaaaaaagaaaggccctgaaaagacagatgaatatctctta
gcaaggttcaaaggcgatggtgtaaaatataaggccaagctgattggcattgatgatgtg
ccagatgcaagaggggataaaatgagccaagactctatgatgaaactaaagggaatggcg
gcagctggtcggtctcagggacaacacaaacaaaggatctgggtcaacatttccctttct
gggataaaaataattgatgagaaaactggggtaatagagcatgaacatccagtaaataag
atttctttcattgcccgtgatgtgacagacaaccgggcatttggttacgtgtgtggagga
gaaggccagcatcagttttttgccataaaaaccgggcaacaggctgaaccattagttgtt
gatcttaaagacctttttcaagttatctataatgtaaagaaaaaggaagaagaaaagaaa
aagatagaggaagccagcaaagcagttgagaatgggagtgaggccctaatgattctagat
gaccaaactaacaaactgaaatcgggtgttgaccagatggatttgtttggggacatgtct
acacctcctgacctaaatagtccaacagaaagcaaagatatcctgttagtggatctaaac
tctgaaatcgacaccaatcagaattctttaagagaaaatccattcttaacaaacggcatc
acctcctgttctcttcctcgaccaacgcctcaggcatccttcttgcctgaaaatgccttt
tctgccaatctcaacttctttcccacccctaatcctgatcctttccgtgacgatcctttc
acacagccagaccaatcgacaccttcttcgtttgattctctcaaatctccagatcagaag
aaagagaattcgagtagctcgtctactccgctgagtaatgggcccctgaatggtgatgtt
gactactttggtcagcaatttgaccagatctctaaccggactggcaaacaggaagctcag
gcaggcccatggcccttttcaagttcgcaaacccagccagcagtgagaactcaaaatggg
gtatctgaaagagaacagaacggcttctctgtcaaatcctccccgaacccttttgtggga
agccctcccaaaggactgtccatacagaatggcgtaaagcaggacttggaaagctctgtc
cagtcctcaccacatgactccatagccattatcccacctccacaaagtaccaaaccagga
agaggcagaaggactgctaagtcttcagccaatgacttgcttgcatcagacatctttgct
cctcccgtctcagaaccttcaggccaggcgtcacccacaggacaacctacagccctgcag
cccaaccctctggatctcttcaaaacaagtgctcctgccccagtggggcccctggtgggt
ctaggtggtgtaactgtcacactccctcaggcaggaccatggaacacagcatctttggtc
ttcaatcagtccccttcaatggctccgggagccatgatgggtggtcaaccttcaggtttt
agtcagcccgtcatttttggtacaagtccagctgtttcaggttggaaccagccttcaccc
tttgcagcctcaactccccctccagtgcctgttgtctggggcccttctgcatctgtggca
cccaatgcttggtcaacaacaagccctttggggaatccttttcagagcaatatttttcca
gctcctgctgtgtccactcagcccccatccatgcactcctctctcctggtcactcctcct
cagccacctcccagagctggccctcccaaggacatctccagtgatgccttcactgcctta
gacccacttggggataaagagatcaaggatgtgaaagaaatgtttaaggatttccaactg
cggcagccacctgctgtgcccgcgcggaagggagagcagacttcttctgggactttgagt
gcctttgccagttatttcaacagcaaggttggcattcctcaggagaatgcagaccatgat
gactttgatgctaatcaactattgaacaagatcaatgaaccaccaaagccagctcccaga
caagtttccctgccagttaccaaatctactgacaatgcatttgagaaccctttctttaaa
gattcttttggttcatcacaagcctctgtggcttcttctcaacctgtatcttctgagatg
tatagggatccatttggaaatccttttgcctaa

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