KEGG   Homo sapiens (human): 10797
Entry
10797             CDS       T01001                                 
Symbol
MTHFD2, NMDMC
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    10797 (MTHFD2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     10797 (MTHFD2)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     10797 (MTHFD2)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH AlaDh_PNT_C PirA-like Memo
Other DBs
NCBI-GeneID: 10797
NCBI-ProteinID: NP_006627
OMIM: 604887
HGNC: 7434
Ensembl: ENSG00000065911
UniProt: P13995
Structure
LinkDB
Position
2:74198615..74217565
AA seq 350 aa
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
NT seq 1053 nt   +upstreamnt  +downstreamnt
atggctgcgacttctctaatgtctgctttggctgcccggctgctgcagcccgcgcacagc
tgctcccttcgccttcgccctttccacctcgcggcagttcgaaatgaagctgttgtcatt
tctggaaggaaactggcccagcagatcaagcaggaagtgcggcaggaggtagaagagtgg
gtggcctcaggcaacaaacggccacacctgagtgtgatcctggttggcgagaatcctgca
agtcactcctatgtcctcaacaaaaccagggcagctgcagttgtgggaatcaacagtgag
acaattatgaaaccagcttcaatttcagaggaagaattgttgaatttaatcaataaactg
aataatgatgataatgtagatggcctccttgttcagttgcctcttccagagcatattgat
gagagaaggatctgcaatgctgtttctccagacaaggatgttgatggctttcatgtaatt
aatgtaggacgaatgtgtttggatcagtattccatgttaccggctactccatggggtgtg
tgggaaataatcaagcgaactggcattccaaccctagggaagaatgtggttgtggctgga
aggtcaaaaaacgttggaatgcccattgcaatgttactgcacacagatggggcgcatgaa
cgtcccggaggtgatgccactgttacaatatctcatcgatatactcccaaagagcagttg
aagaaacatacaattcttgcagatattgtaatatctgctgcaggtattccaaatctgatc
acagcagatatgatcaaggaaggagcagcagtcattgatgtgggaataaatagagttcac
gatcctgtaactgccaaacccaagttggttggagatgtggattttgaaggagtcagacaa
aaagctgggtatatcactccagttcctggaggtgttggccccatgacagtggcaatgcta
atgaagaataccattattgctgcaaaaaaggtgctgaggcttgaagagcgagaagtgctg
aagtctaaagagcttggggtagccactaattaa

KEGG   Homo sapiens (human): 441024
Entry
441024            CDS       T01001                                 
Symbol
MTHFD2L
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    441024 (MTHFD2L)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     441024 (MTHFD2L)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     441024 (MTHFD2L)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 441024
NCBI-ProteinID: NP_001138450
OMIM: 614047
HGNC: 31865
Ensembl: ENSG00000163738
UniProt: Q9H903
Structure
LinkDB
Position
4:74114560..74303099
AA seq 347 aa
MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMA
KHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPK
DVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC
LDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDA
TVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGK
TKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
NT seq 1044 nt   +upstreamnt  +downstreamnt
atgacggtgccggtccgcggcttctcgctgctccgcggccgccttggccgagcgccggcg
ttgggcagaagcacagcaccctccgtaagggcaccgggagagcccgggagtgcgttccgg
ggctttcggagcagcggtgtgagacatgaagccattattatatcaggaaccgaaatggcc
aagcatatccagaaagaaatacagcgaggtgtggaatcatgggtttcccttggaaacaga
agacctcacctcagtataattttagtgggagataacccagcaagccatacatatgtcagg
aataagataagagctgcctctgctgtaggtatttgtagtgagctcattctaaaacctaag
gatgtttctcaggaagaacttttggacgtaactgatcaattgaatatggacccaagagtc
agcggtatattagttcagttaccactaccagaccacgttgatgagcgaacaatatgcaat
ggaattgccccagaaaaagatgtagatggatttcatattatcaatattggaagattgtgc
cttgatcagcattctctcatacctgccactgccagtgctgtttgggaaataataaaaaga
acaggaattcaaacatttggaaaaaatgtggttgtggctggaagatccaagaacgtaggg
atgcctattgccatgcttttacacactgatggagagcatgaacggccaggaggtgatgca
actgtgacaatagctcacagatacacccccaaagagcaactgaagattcatacgcagctg
gcagatattatcatagttgctgcaggtattccaaagttgattacgtctgatatggttaaa
gaaggtgctgctgtaattgatgtgggtatcaactatgtccacgatccagtgacaggaaag
acaaaattagttggagatgtggacttcgaagctgttaaaaagaaagctggctttatcact
ccagttccaggaggtgtgggacccatgacagtggcaatgcttctgaagaacacccttctg
gcagctaaaaaaatcatttactag

KEGG   Homo sapiens (human): 4522
Entry
4522              CDS       T01001                                 
Symbol
MTHFD1, CIMAH, MTHFC, MTHFD
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04981  Folate transport and metabolism
Module
hsa_M00141  C1-unit interconversion, eukaryotes
Network
nt06038  Folate metabolism
  Element
N01726  Folate cycle
Disease
H00262  Neural tube defects, folate-sensitive
H02761  Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    4522 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    4522 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    4522 (MTHFD1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     4522 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     4522 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     4522 (MTHFD1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   4522 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall
Other DBs
NCBI-GeneID: 4522
NCBI-ProteinID: NP_005947
OMIM: 172460
HGNC: 7432
Ensembl: ENSG00000100714
UniProt: P11586
Structure
LinkDB
Position
14:64388353..64460025
AA seq 935 aa
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcgccagcagaaatcctgaacgggaaggagatctccgcgcaaataagggcgagactg
aaaaatcaagtcactcagttgaaggagcaagtacctggtttcacaccacgcctggcaata
ttacaggttggcaacagagatgattccaatctttatataaatgtgaagctgaaggctgct
gaagagattgggatcaaagccactcacattaagttaccaagaacaaccacagaatctgag
gtgatgaagtacattacatctttgaatgaagactctactgtacatgggttcttagtgcag
ctacctttagattcagagaattccattaacactgaagaagtgatcaatgctattgcaccc
gagaaggatgtggatggattgactagcatcaatgctgggaaacttgctagaggtgacctc
aatgactgtttcattccttgtacgcctaagggatgcttggaactcatcaaagagacaggg
gtgccgattgccggaaggcatgctgtggtggttgggcgcagtaaaatagttggggccccg
atgcatgacttgcttctgtggaacaatgccacagtgaccacctgccactccaagactgcc
catctggatgaggaggtaaataaaggtgacatcctggtggttgcaactggtcagcctgaa
atggttaaaggggagtggatcaaacctggggcaatagtcatcgactgtggaatcaattat
gtcccagatgataaaaaaccaaatgggagaaaagttgtgggtgatgtggcatacgacgag
gccaaagagagggcgagcttcatcactcctgttcctggcggcgtagggcccatgacagtt
gcaatgctcatgcagagcacagtagagagtgccaagcgtttcctggagaaatttaagcca
ggaaagtggatgattcagtataacaaccttaacctcaagacacctgttccaagtgacatt
gatatatcacgatcttgtaaaccgaagcccattggtaagctggctcgagaaattggtctg
ctgtctgaagaggtagaattatatggtgaaacaaaggccaaagttctgctgtcagcacta
gaacgcctgaagcaccggcctgatgggaaatacgtggtggtgactggaataactccaaca
cccctgggagaagggaaaagcacaactacaatcgggctagtgcaagcccttggtgcccat
ctctaccagaatgtctttgcgtgtgtgcgacagccttctcagggccccacctttggaata
aaaggtggcgctgcaggaggcggctactcccaggtcattcctatggaagagtttaatctc
cacctcacaggtgacatccatgccatcactgcagctaataacctcgttgctgcggccatt
gatgctcggatatttcatgaactgacccagacagacaaggctctctttaatcgtttggtg
ccatcagtaaatggagtgagaaggttctctgacatccaaatccgaaggttaaagagacta
ggcattgaaaagactgaccctaccacactgacagatgaagagataaacagatttgcaaga
ttggacattgatccagaaaccataacttggcaaagagtgttggataccaatgatagattc
ctgaggaagatcacgattggacaggctccaacggagaagggtcacacacggacggcccag
tttgatatctctgtggccagtgaaattatggctgtcctggctctcaccacttctctagaa
gacatgagagagagactgggcaaaatggtggtggcatccagtaagaaaggagagcccgtc
agtgccgaagatctgggggtgagtggtgcactgacagtgcttatgaaggacgcaatcaag
cccaatctcatgcagacactggagggcactccagtgtttgtccatgctggcccgtttgcc
aacatcgcacatggcaattcctccatcattgcagaccggatcgcactcaagcttgttggc
ccagaagggtttgtagtgacggaagcaggatttggagcagacattggaatggaaaagttt
tttaacatcaaatgccggtattccggcctctgcccccacgtggtggtgcttgttgccact
gtcagggctctcaagatgcacgggggcggccccacggtcactgctggactgcctcttccc
aaggcttacatacaggagaacctggagctggttgaaaaaggcttcagtaacttgaagaaa
caaattgaaaatgccagaatgtttggaattccagtagtagtggccgtgaatgcattcaag
acggatacagagtctgagctggacctcatcagccgcctttccagagaacatggggctttt
gatgccgtgaagtgcactcactgggcagaagggggcaagggtgccttagccctggctcag
gccgtccagagagcagcacaagcacccagcagcttccagctcctttatgacctcaagctc
ccagttgaggataaaatcaggatcattgcacagaagatctatggagcagatgacattgaa
ttacttcccgaagctcaacacaaagctgaagtctacacgaagcagggctttgggaatctc
cccatctgcatggctaaaacacacttgtctttgtctcacaacccagagcaaaaaggtgtc
cctacaggcttcattctgcccattcgcgacatccgcgccagcgttggggctggttttctg
taccccttagtaggaacgatgagcacaatgcctggactccccacccggccctgtttttat
gatattgatttggaccctgaaacagaacaggtgaatggattattctaa

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