| Entry |
|
|---|
| Symbol |
LIAS, HGCLAS, HUSSY-01, LAS, LIP1, LS, PDHLD
|
|---|
| Name |
(RefSeq) lipoic acid synthetase
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
|
|---|
| Module |
| hsa_M00882 | Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H |
| hsa_M00883 | Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2 |
|
|---|
| Network |
|
|---|
| Element |
| N01684 | Lipoic acid biosynthesis |
|
|---|
| Disease |
| H02438 | Hyperglycinemia, lactic acidosis, and seizures |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
11019 (LIAS)
Enzymes [BR:hsa01000]
2. Transferases
2.8 Transferring sulfur-containing groups
2.8.1 Sulfurtransferases
2.8.1.8 lipoyl synthase
11019 (LIAS)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| Position |
4:39459056..39479506
|
|---|
| AA seq |
372 aa
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWD
EYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGG
GEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSV
DRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVET
VPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFL
KNLVAKRKTKDL |
|---|
| NT seq |
1119 nt +upstreamnt +downstreamnt
atgtctctacgctgcggggatgcagcccgcaccctggggccccgggtatttgggagatat
ttttgcagcccagtcagaccgttaagctccttgccagataaaaaaaaggaactcctacag
aatggaccagaccttcaagattttgtatctggtgatcttgcagacaggagcacctgggat
gaatataaaggaaacctaaaacgccagaaaggagaaaggttaagactacctccatggcta
aagacagagattcccatggggaaaaattacaataaactgaaaaatactttgcggaattta
aatctccatacagtatgtgaggaagctcgatgtcccaatattggagagtgttggggaggt
ggagaatatgccaccgccacagccacgatcatgttgatgggtgacacatgtacaagaggt
tgcagattttgttctgttaagactgcaagaaatcctcctccactggatgccagtgagccc
tacaatactgcaaaggcaattgcagaatggggtctggattatgttgtcctgacatctgtg
gatcgagatgatatgcctgatgggggagctgaacacattgcaaagaccgtatcatattta
aaggaaaggaatccaaaaatccttgtggagtgtcttactcctgattttcgaggtgatctc
aaagcaatagaaaaagttgctctgtcaggattagatgtgtatgcacataatgtagaaaca
gtcccggaattacagagtaaggttcgtgatcctcgggccaattttgatcagtccctacgt
gtactgaaacatgccaagaaggttcagcctgatgttatttctaaaacatctataatgttg
ggtttaggcgagaatgatgagcaagtatatgcaacaatgaaagcacttcgtgaggcagat
gtagactgcttgactttaggacaatatatgcagccaacaaggcgtcaccttaaggttgaa
gaatatattactcctgaaaaattcaaatactgggaaaaagtaggaaatgaacttggattt
cattatactgcaagtggccctttggtgcgttcttcatataaagcaggtgaatttttcctg
aaaaatctagtggctaaaagaaaaacaaaagacctctaa |
|---|
