KEGG   Homo sapiens (human): 11091
Entry
11091             CDS       T01001                                 
Symbol
WDR5, BIG-3, BIG3, CFAP89, SWD3
Name
(RefSeq) WD repeat-containing protein 5 isoform 1
  KO
K14963  COMPASS component SWD3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04934  Cushing syndrome
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    11091 (WDR5)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    11091 (WDR5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    11091 (WDR5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    ATAC complex
     11091 (WDR5)
    NSL complex
     11091 (WDR5)
   HMT complexes
    COMPASS/SET1 complex
     11091 (WDR5)
    COMPASS/SET1 complex (yeast)
     11091 (WDR5)
    MLL-HCF complex
     11091 (WDR5)
    MLL3/MLL4 complex
     11091 (WDR5)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     11091 (WDR5)
SSDB
Motif
Pfam: Beta-prop_WDR5 Beta-prop_IFT122_1st WD40 WD40_Prp19 Beta-prop_THOC3 Beta-prop_WDR3_1st Beta-prop_WDR3_2nd WD40_WDHD1_1st WD40_CDC20-Fz EIF3I Beta-prop_EML_2 Beta-prop_CAF1B_HIR1 Beta-prop_WDR36-Utp21_2nd Beta-prop_TEP1_2nd WD40_Gbeta WDR55 WD40_MABP1-WDR62_2nd ANAPC4_WD40 Beta-prop_WDR75_1st Beta-prop_EML Beta-prop_WDR36-Utp21_1st Beta-prop_Aladin DSE1_N WD40_MABP1-WDR62_1st Beta-prop_TEP1_C Beta-prop_WDR90_POC16_2nd CFAP251_N Beta-prop_WDR41 NBCH_WD40 Beta-prop_DCAF4 Beta-prop_SCAP Beta-prop_RIG_2nd Beta-prop_EIPR1 Beta-prop_VPS8 WD40_RFWD3 PAC11 eIF2A Beta-prop_Nup120_160 WDR90_beta-prop_4th Beta-prop_SPT8 ASA1 Beta-prop_NWD2_C Beta-prop_WDR35_TULP_N Beta-prop_NOL10_N Beta-prop_ACSF4 Beta-prop_WDR19_1st TRM82_WD Beta-prop_IFT140_1st Beta-prop_RIG_1st Beta-prop_DCAF12 Beta-prop_HPS5 RMC1_N Beta-prop_WDR75_2nd Beta-prop_NUP159_NUP214 WD40_like PROPPIN Ge1_WD40 Tricorn_2nd Beta-prop_Vps41 WDR54 Beta-prop_LRRK2 Beta-prop_WDR11_1st VID27 Nucleoporin_N CDtoxinA
Other DBs
NCBI-GeneID: 11091
NCBI-ProteinID: NP_001371338
OMIM: 609012
HGNC: 12757
UniProt: P61964
Structure
LinkDB
Position
9:134135199..134159968
AA seq 334 aa
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
NT seq 1005 nt   +upstreamnt  +downstreamnt
atggcgacggaggagaagaagcccgagaccgaggccgccagagcacagccaaccccttcg
tcatccgccactcagagcaagcctacacctgtgaagccaaactatgctctaaagttcacc
cttgctggccacaccaaagcagtgtcctccgtgaaattcagcccgaatggagagtggctg
gcaagttcatctgctgataaacttattaaaatttggggcgcgtatgatgggaaatttgag
aaaaccatatctggtcacaagctgggaatatccgatgtagcctggtcgtcagattctaac
cttcttgtttctgcctcagatgacaaaaccttgaagatatgggacgtgagctcgggcaag
tgtctgaaaaccctgaagggacacagtaattatgtcttttgctgcaacttcaatccccag
tccaaccttattgtctcaggatcctttgacgaaagcgtgaggatatgggatgtgaaaaca
gggaagtgcctcaagactttgccagctcactcggatccagtctcggccgttcattttaat
cgtgatggatccttgatagtttcaagtagctatgatggtctctgtcgcatctgggacacc
gcctcaggccagtgcctgaagacgctcatcgatgacgacaacccccccgtgtcttttgtg
aagttctccccgaacggcaaatacatcctggccgccacgctggacaacactctgaagctc
tgggactacagcaaggggaagtgcctgaagacgtacactggccacaagaatgagaaatac
tgcatatttgccaatttctctgttactggtgggaagtggattgtgtctggctcagaggat
aaccttgtttacatctggaaccttcagacgaaagagattgtacagaaactacaaggccac
acagatgtcgtgatctcaacagcttgtcacccaacagaaaacatcatcgcctctgctgcg
ctagaaaatgacaaaacaattaaactgtggaagagtgactgctaa

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