Homo sapiens (human): 113235
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Entry
113235 CDS
T01001
Symbol
SLC46A1, G21, HCP1, HsPCFT, PCFT, hPCFT
Name
(RefSeq) solute carrier family 46 member 1
KO
K14613
MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04977
Vitamin digestion and absorption
hsa04978
Mineral absorption
hsa04981
Folate transport and metabolism
Disease
H01252
Hereditary folate malabsorption
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04977 Vitamin digestion and absorption
113235 (SLC46A1)
04981 Folate transport and metabolism
113235 (SLC46A1)
04978 Mineral absorption
113235 (SLC46A1)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
113235 (SLC46A1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
113235 (SLC46A1)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC46: Folate transporter
113235 (SLC46A1)
Major facilitator superfamily (MFS)
Organic acid transporters
Proton coupled folate transporter/heme carrier protein (PCFT/HCP) family [TC:
2.A.1.50
]
113235 (SLC46A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MFS_1
Sugar_tr
Motif
Other DBs
NCBI-GeneID:
113235
NCBI-ProteinID:
NP_542400
OMIM:
611672
HGNC:
30521
Ensembl:
ENSG00000076351
UniProt:
Q96NT5
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Position
17:complement(28394642..28406592)
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AA seq
459 aa
AA seq
DB search
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
NT seq
1380 nt
NT seq
+upstream
nt +downstream
nt
atggaggggagcgcgagccccccggaaaagccccgcgcccgccctgcggctgccgtgctg
tgccggggcccggtagagccgctggtcttcctggccaactttgccttggtcctgcagggc
ccgctcaccacgcagtatctgtggcaccgcttcagcgccgacctcggctacaatggcacc
cgccaaagggggggctgcagcaaccgcagcgcggaccccaccatgcaggaagtggagacc
cttacctcccactggaccctctacatgaacgtgggcggcttcctggtggggctcttctcg
tccaccctgctgggagcttggagcgacagtgtgggccgccgcccgctgctagtgctggcc
tcgctgggcctgctgctccaggccctagtgtccgtttttgtggtgcagctgcagctccac
gtcggctacttcgtgctgggtcgcatcctttgtgccctcctcggcgacttcggtggcctt
ctggctgctagctttgcgtccgtggcagatgtcagctccagtcgcagccgcaccttccgg
atggccctgctggaagccagcatcggggtggctgggatgctggcaagcctcctcgggggc
cactggctccgggcccagggttatgccaaccccttctggctggccttggccttgctgata
gccatgactctctatgcagctttctgctttggtgagaccttaaaggagccaaagtccacc
cggctcttcacgttccgtcaccaccgatccattgtccagctctatgtggctcccgcccca
gagaagtccaggaaacatttagccctctactcactggccatcttcgtggtgatcactgtg
cactttggggcccaggacatcttaaccctttatgaactaagcacacccctctgctgggac
tccaaactaatcggctatggttctgcagctcagcatctcccctacctcaccagcctgctg
gccctgaagctcctgcagtactgcctggccgatgcctgggtagctgagatcggcctggcc
ttcaacatcctggggatggtggtctttgcctttgccactatcacgcctctcatgttcaca
ggatatgggttgcttttcctgtcattagtcatcacacctgtcatccgggctaaactctcc
aagctggtgagagagacagagcagggtgctctcttttctgctgtggcctgtgtgaatagc
ctggccatgctgacggcctccggcatcttcaactcactctacccagccactctgaacttt
atgaaggggttccccttcctcctgggagctggcctcctgctcatcccggctgttctgatt
gggatgctggaaaaggctgatcctcacctcgagttccagcagtttccccagagcccctga
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