KEGG   Homo sapiens (human): 1179
Entry
1179              CDS       T01001                                 
Symbol
CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1
Name
(RefSeq) chloride channel accessory 1
  KO
K05027  calcium-activated chloride channel regulator 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04924  Renin secretion
hsa04972  Pancreatic secretion
Drug target
Crofelemer: D03605<US>
Niflumic acid: D08275
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1179 (CLCA1)
  09154 Digestive system
   04972 Pancreatic secretion
    1179 (CLCA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1179 (CLCA1)
Ion channels [BR:hsa04040]
 Chloride channels
  Chloride channel, calcium-activated (CaCC)
   1179 (CLCA1)
SSDB
Motif
Pfam: CLCA VWA_2 VWA VWA_CoxE Cas_Cas1
Other DBs
NCBI-GeneID: 1179
NCBI-ProteinID: NP_001276
OMIM: 603906
HGNC: 2015
Ensembl: ENSG00000016490
Vega: OTTHUMG00000010254
Pharos: A8K7I4(Tbio)
UniProt: A8K7I4
Structure
LinkDB
Position
1:86468927..86500259
AA seq 914 aa
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQA
SLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTE
QMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNG
RIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFA
QHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLL
QIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELI
QINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISG
CFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNG
AVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQG
GFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKD
TSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSR
YFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDD
VQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDY
DHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDL
FIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILK
IMWKWIGELQLSIA
NT seq 2745 nt   +upstreamnt  +downstreamnt
atggggccatttaagagttctgtgttcatcttgattcttcaccttctagaaggggccctg
agtaattcactcattcagctgaacaacaatggctatgaaggcattgtcgttgcaatcgac
cccaatgtgccagaagatgaaacactcattcaacaaataaaggacatggtgacccaggca
tctctgtatctgcttgaagctacaggaaagcgattttatttcaaaaatgttgccattttg
attcctgaaacatggaagacaaaggctgactatgtgagaccaaaacttgagacctacaaa
aatgctgatgttctggttgctgagtctactcctccaggtaatgatgaaccctacactgag
cagatgggcaactgtggagagaagggtgaaaggatccacctcactcctgatttcattgca
ggaaaaaagttagctgaatatggaccacaaggtagggcatttgtccatgagtgggctcat
ctacgatggggagtatttgacgagtacaataatgatgagaaattctacttatccaatgga
agaatacaagcagtaagatgttcagcaggtattactggtacaaatgtagtaaagaagtgt
cagggaggcagctgttacaccaaaagatgcacattcaataaagtaacaggactctatgaa
aaaggatgtgagtttgttctccaatcccgccagacggagaaggcttctataatgtttgca
caacatgttgattctatagttgaattctgtacagaacaaaaccacaacaaagaagctcca
aacaagcaaaatcaaaaatgcaatctccgaagcacatgggaagtgatccgtgattctgag
gactttaagaaaaccactcctatgacaacacagccaccaaatcccaccttctcattgctg
cagattggacaaagaattgtgtgtttagtccttgacaaatctggaagcatggcgactggt
aaccgcctcaatcgactgaatcaagcaggccagcttttcctgctgcagacagttgagctg
gggtcctgggttgggatggtgacatttgacagtgctgcccatgtacaaaatgaactcata
cagataaacagtggcagtgacagggacacactcgccaaaagattacctgcagcagcttca
ggagggacgtccatctgcagcgggcttcgatcggcatttactgtgattaggaagaaatat
ccaactgatggatctgaaattgtgctgctgacggatggggaagacaacactataagtggg
tgctttaacgaggtcaaacaaagtggtgccatcatccacacagtcgctttggggccctct
gcagctcaagaactagaggagctgtccaaaatgacaggaggtttacagacatatgcttca
gatcaagttcagaacaatggcctcattgatgcttttggggccctttcatcaggaaatgga
gctgtctctcagcgctccatccagcttgagagtaagggattaaccctccagaacagccag
tggatgaatggcacagtgatcgtggacagcaccgtgggaaaggacactttgtttcttatc
acctggacaatgcagcctccccaaatccttctctgggatcccagtggacagaagcaaggt
ggctttgtagtggacaaaaacaccaaaatggcctacctccaaatcccaggcattgctaag
gttggcacttggaaatacagtctgcaagcaagctcacaaaccttgaccctgactgtcacg
tcccgtgcgtccaatgctaccctgcctccaattacagtgacttccaaaacgaacaaggac
accagcaaattccccagccctctggtagtttatgcaaatattcgccaaggagcctcccca
attctcagggccagtgtcacagccctgattgaatcagtgaatggaaaaacagttaccttg
gaactactggataatggagcaggtgctgatgctactaaggatgacggtgtctactcaagg
tatttcacaacttatgacacgaatggtagatacagtgtaaaagtgcgggctctgggagga
gttaacgcagccagacggagagtgataccccagcagagtggagcactgtacatacctggc
tggattgagaatgatgaaatacaatggaatccaccaagacctgaaattaataaggatgat
gttcaacacaagcaagtgtgtttcagcagaacatcctcgggaggctcatttgtggcttct
gatgtcccaaatgctcccatacctgatctcttcccacctggccaaatcaccgacctgaag
gcggaaattcacgggggcagtctcattaatctgacttggacagctcctggggatgattat
gaccatggaacagctcacaagtatatcattcgaataagtacaagtattcttgatctcaga
gacaagttcaatgaatctcttcaagtgaatactactgctctcatcccaaaggaagccaac
tctgaggaagtctttttgtttaaaccagaaaacattacttttgaaaatggcacagatctt
ttcattgctattcaggctgttgataaggtcgatctgaaatcagaaatatccaacattgca
cgagtatctttgtttattcctccacagactccgccagagacacctagtcctgatgaaacg
tctgctccttgtcctaatattcatatcaacagcaccattcctggcattcacattttaaaa
attatgtggaagtggataggagaactgcagctgtcaatagcctag

KEGG   Homo sapiens (human): 22802
Entry
22802             CDS       T01001                                 
Symbol
CLCA4, CaCC, CaCC2
Name
(RefSeq) chloride channel accessory 4
  KO
K05030  calcium-activated chloride channel regulator 3/4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04924  Renin secretion
hsa04972  Pancreatic secretion
Drug target
Crofelemer: D03605<US>
Niflumic acid: D08275
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    22802 (CLCA4)
  09154 Digestive system
   04972 Pancreatic secretion
    22802 (CLCA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    22802 (CLCA4)
Ion channels [BR:hsa04040]
 Chloride channels
  Chloride channel, calcium-activated (CaCC)
   22802 (CLCA4)
SSDB
Motif
Pfam: CLCA VWA VWA_2 VWA_CoxE
Other DBs
NCBI-GeneID: 22802
NCBI-ProteinID: NP_036260
OMIM: 616857
HGNC: 2018
Ensembl: ENSG00000016602
Vega: OTTHUMG00000010260
Pharos: Q14CN2(Tbio)
UniProt: Q14CN2
LinkDB
Position
1:86547078..86580754
AA seq 919 aa
MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTAS
TYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQ
FTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSK
KIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFM
QSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLL
KISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLI
QIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTAS
SCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGN
TDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIM
ENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKM
NKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGV
YSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEID
EDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDN
FDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATH
IFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTL
VLSVIGSVVIVNFILSTTI
NT seq 2760 nt   +upstreamnt  +downstreamnt
atggggttattcagaggttttgttttcctcttagttctgtgcctgctgcaccagtcaaat
acttccttcattaagctgaataataatggctttgaagatattgtcattgttatagatcct
agtgtgccagaagatgaaaaaataattgaacaaatagaggatatggtgactacagcttct
acgtacctgtttgaagccacagaaaaaagattttttttcaaaaatgtatctatattaatt
cctgagaattggaaggaaaatcctcagtacaaaaggccaaaacatgaaaaccataaacat
gctgatgttatagttgcaccacctacactcccaggtagagatgaaccatacaccaagcag
ttcacagaatgtggagagaaaggcgaatacattcacttcacccctgaccttctacttgga
aaaaaacaaaatgaatatggaccaccaggcaaactgtttgtccatgagtgggctcacctc
cggtggggagtgtttgatgagtacaatgaagatcagcctttctaccgtgctaagtcaaaa
aaaatcgaagcaacaaggtgttccgcaggtatctctggtagaaatagagtttataagtgt
caaggaggcagctgtcttagtagagcatgcagaattgattctacaacaaaactgtatgga
aaagattgtcaattctttcctgataaagtacaaacagaaaaagcatccataatgtttatg
caaagtattgattctgttgttgaattttgtaacgaaaaaacccataatcaagaagctcca
agcctacaaaacataaagtgcaattttagaagtacatgggaggtgattagcaattctgag
gattttaaaaacaccatacccatggtgacaccacctcctccacctgtcttctcattgctg
aagatcagtcaaagaattgtgtgcttagttcttgataagtctggaagcatggggggtaag
gaccgcctaaatcgaatgaatcaagcagcaaaacatttcctgctgcagactgttgaaaat
ggatcctgggtggggatggttcactttgatagtactgccactattgtaaataagctaatc
caaataaaaagcagtgatgaaagaaacacactcatggcaggattacctacatatcctctg
ggaggaacttccatctgctctggaattaaatatgcatttcaggtgattggagagctacat
tcccaactcgatggatccgaagtactgctgctgactgatggggaggataacactgcaagt
tcttgtattgatgaagtgaaacaaagtggggccattgttcattttattgctttgggaaga
gctgctgatgaagcagtaatagagatgagcaagataacaggaggaagtcatttttatgtt
tcagatgaagctcagaacaatggcctcattgatgcttttggggctcttacatcaggaaat
actgatctctcccagaagtcccttcagctcgaaagtaagggattaacactgaatagtaat
gcctggatgaacgacactgtcataattgatagtacagtgggaaaggacacgttctttctc
atcacatggaacagtctgcctcccagtatttctctctgggatcccagtggaacaataatg
gaaaatttcacagtggatgcaacttccaaaatggcctatctcagtattccaggaactgca
aaggtgggcacttgggcatacaatcttcaagccaaagcgaacccagaaacattaactatt
acagtaacttctcgagcagcaaattcttctgtgcctccaatcacagtgaatgctaaaatg
aataaggacgtaaacagtttccccagcccaatgattgtttacgcagaaattctacaagga
tatgtacctgttcttggagccaatgtgactgctttcattgaatcacagaatggacataca
gaagttttggaacttttggataatggtgcaggcgctgattctttcaagaatgatggagtc
tactccaggtattttacagcatatacagaaaatggcagatatagcttaaaagttcgggct
catggaggagcaaacactgccaggctaaaattacggcctccactgaatagagccgcgtac
ataccaggctgggtagtgaacggggaaattgaagcaaacccgccaagacctgaaattgat
gaggatactcagaccaccttggaggatttcagccgaacagcatccggaggtgcatttgtg
gtatcacaagtcccaagccttcccttgcctgaccaatacccaccaagtcaaatcacagac
cttgatgccacagttcatgaggataagattattcttacatggacagcaccaggagataat
tttgatgttggaaaagttcaacgttatatcataagaataagtgcaagtattcttgatcta
agagacagttttgatgatgctcttcaagtaaatactactgatctgtcaccaaaggaggcc
aactccaaggaaagctttgcatttaaaccagaaaatatctcagaagaaaatgcaacccac
atatttattgccattaaaagtatagataaaagcaatttgacatcaaaagtatccaacatt
gcacaagtaactttgtttatccctcaagcaaatcctgatgacattgatcctacacctact
cctactcctactcctactcctgataaaagtcataattctggagttaatatttctacgctg
gtattgtctgtgattgggtctgttgtaattgttaactttattttaagtaccaccatttga

KEGG   Homo sapiens (human): 9635
Entry
9635              CDS       T01001                                 
Symbol
CLCA2, CACC, CACC3, CLCRG2, CaCC-3
Name
(RefSeq) chloride channel accessory 2
  KO
K05028  calcium-activated chloride channel regulator 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04924  Renin secretion
hsa04972  Pancreatic secretion
Drug target
Crofelemer: D03605<US>
Niflumic acid: D08275
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    9635 (CLCA2)
  09154 Digestive system
   04972 Pancreatic secretion
    9635 (CLCA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    9635 (CLCA2)
Ion channels [BR:hsa04040]
 Chloride channels
  Chloride channel, calcium-activated (CaCC)
   9635 (CLCA2)
SSDB
Motif
Pfam: CLCA VWA_2 SusE
Other DBs
NCBI-GeneID: 9635
NCBI-ProteinID: NP_006527
OMIM: 604003
HGNC: 2016
Ensembl: ENSG00000137975
Vega: OTTHUMG00000010256
Pharos: Q9UQC9(Tbio)
UniProt: Q9UQC9
LinkDB
Position
1:86424171..86456553
AA seq 943 aa
MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISN
IKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAH
GDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNND
KPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASI
MFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPP
TFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEI
RAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTS
GDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAF
SRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIIL
FDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNS
AVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDG
AGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGN
IQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEE
LTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFS
PQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDY
LILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
NT seq 2832 nt   +upstreamnt  +downstreamnt
atgacccaaaggagcattgcaggtcctatttgcaacctgaagtttgtgactctcctggtt
gccttaagttcagaactcccattcctgggagctggagtacagcttcaagacaatgggtat
aatggattgctcattgcaattaatcctcaggtacctgagaatcagaacctcatctcaaac
attaaggaaatgataactgaagcttcattttacctatttaatgctaccaagagaagagta
tttttcagaaatataaagattttaatacctgccacatggaaagctaataataacagcaaa
ataaaacaagaatcatatgaaaaggcaaatgtcatagtgactgactggtatggggcacat
ggagatgatccatacaccctacaatacagagggtgtggaaaagagggaaaatacattcat
ttcacacctaatttcctactgaatgataacttaacagctggctacggatcacgaggccga
gtgtttgtccatgaatgggcccacctccgttggggtgtgttcgatgagtataacaatgac
aaacctttctacataaatgggcaaaatcaaattaaagtgacaaggtgttcatctgacatc
acaggcatttttgtgtgtgaaaaaggtccttgcccccaagaaaactgtattattagtaag
ctttttaaagaaggatgcacctttatctacaatagcacccaaaatgcaactgcatcaata
atgttcatgcaaagtttatcttctgtggttgaattttgtaatgcaagtacccacaaccaa
gaagcaccaaacctacagaaccagatgtgcagcctcagaagtgcatgggatgtaatcaca
gactctgctgactttcaccacagctttcccatgaatgggactgagcttccacctcctccc
acattctcgcttgtacaggctggtgacaaagtggtctgtttagtgctggatgtgtccagc
aagatggcagaggctgacagactccttcaactacaacaagccgcagaattttatttgatg
cagattgttgaaattcataccttcgtgggcattgccagtttcgacagcaaaggagagatc
agagcccagctacaccaaattaacagcaatgatgatcgaaagttgctggtttcatatctg
cccaccactgtatcagctaaaacagacatcagcatttgttcagggcttaagaaaggattt
gaggtggttgaaaaactgaatggaaaagcttatggctctgtgatgatattagtgaccagc
ggagatgataagcttcttggcaattgcttacccactgtgctcagcagtggttcaacaatt
cactccattgccctgggttcatctgcagccccaaatctggaggaattatcacgtcttaca
ggaggtttaaagttctttgttccagatatatcaaactccaatagcatgattgatgctttc
agtagaatttcctctggaactggagacattttccagcaacatattcagcttgaaagtaca
ggtgaaaatgtcaaacctcaccatcaattgaaaaacacagtgactgtggataatactgtg
ggcaacgacactatgtttctagttacgtggcaggccagtggtcctcctgagattatatta
tttgatcctgatggacgaaaatactacacaaataattttatcaccaatctaacttttcgg
acagctagtctttggattccaggaacagctaagcctgggcactggacttacaccctgaac
aatacccatcattctctgcaagccctgaaagtgacagtgacctctcgcgcctccaactca
gctgtgcccccagccactgtggaagcctttgtggaaagagacagcctccattttcctcat
cctgtgatgatttatgccaatgtgaaacagggattttatcccattcttaatgccactgtc
actgccacagttgagccagagactggagatcctgttacgctgagactccttgatgatgga
gcaggtgctgatgttataaaaaatgatggaatttactcgaggtattttttctcctttgct
gcaaatggtagatatagcttgaaagtgcatgtcaatcactctcccagcataagcacccca
gcccactctattccagggagtcatgctatgtatgtaccaggttacacagcaaacggtaat
attcagatgaatgctccaaggaaatcagtaggcagaaatgaggaggagcgaaagtggggc
tttagccgagtcagctcaggaggctccttttcagtgctgggagttccagctggcccccac
cctgatgtgtttccaccatgcaaaattattgacctggaagctgtaaaagtagaagaggaa
ttgaccctatcttggacagcacctggagaagactttgatcagggccaggctacaagctat
gaaataagaatgagtaaaagtctacagaatatccaagatgactttaacaatgctatttta
gtaaatacatcaaagcgaaatcctcagcaagctggcatcagggagatatttacgttctca
ccccaaatttccacgaatggacctgaacatcagccaaatggagaaacacatgaaagccac
agaatttatgttgcaatacgagcaatggataggaactccttacagtctgctgtatctaac
attgcccaggcgcctctgtttattccccccaattctgatcctgtacctgccagagattat
cttatattgaaaggagttttaacagcaatgggtttgataggaatcatttgccttattata
gttgtgacacatcatactttaagcaggaaaaagagagcagacaagaaagagaatggaaca
aaattattataa

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