Homo sapiens (human): 1200
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Entry
1200 CDS
T01001
Symbol
TPP1, CLN2, GIG1, LPIC, SCAR7, TPP-1
Name
(RefSeq) tripeptidyl peptidase 1
KO
K01279
tripeptidyl-peptidase I [EC:
3.4.14.9
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04142
Lysosome
Disease
H00149
Neuronal ceroid lipofuscinosis
H01891
Autosomal recessive spinocerebellar ataxias
H02278
Jansky-Bielschowsky disease
Drug target
Cerliponase alfa:
D10813
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
1200 (TPP1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
1200 (TPP1)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
1200 (TPP1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
1200 (TPP1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.14.9 tripeptidyl-peptidase I
1200 (TPP1)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S53
1200 (TPP1)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Subtilisin family
1200 (TPP1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
1200 (TPP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pro-kuma_activ
Peptidase_S8
Motif
Other DBs
NCBI-GeneID:
1200
NCBI-ProteinID:
NP_000382
OMIM:
607998
HGNC:
2073
Ensembl:
ENSG00000166340
UniProt:
O14773
Structure
PDB
LinkDB
All DBs
Position
11:complement(6612768..6619422)
Genome browser
AA seq
563 aa
AA seq
DB search
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVER
LSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFL
TCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTS
SLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDL
AQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG
QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGD
SGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPS
YQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPV
FGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGP
GWDPVTGWGTPNFPALLKTLLNP
NT seq
1692 nt
NT seq
+upstream
nt +downstream
nt
atgggactccaagcctgcctcctagggctctttgccctcatcctctctggcaaatgcagt
tacagcccggagcccgaccagcggaggacgctgcccccaggctgggtgtccctgggccgt
gcggaccctgaggaagagctgagtctcacctttgccctgagacagcagaatgtggaaaga
ctctcggagctggtgcaggctgtgtcggatcccagctctcctcaatacggaaaatacctg
accctagagaatgtggctgatctggtgaggccatccccactgaccctccacacggtgcaa
aaatggctcttggcagccggagcccagaagtgccattctgtgatcacacaggactttctg
acttgctggctgagcatccgacaagcagagctgctgctccctggggctgagtttcatcac
tatgtgggaggacctacggaaacccatgttgtaaggtccccacatccctaccagcttcca
caggccttggccccccatgtggactttgtggggggactgcaccgttttcccccaacatca
tccctgaggcaacgtcctgagccgcaggtgacagggactgtaggcctgcatctgggggta
accccctctgtgatccgtaagcgatacaacttgacctcacaagacgtgggctctggcacc
agcaataacagccaagcctgtgcccagttcctggagcagtatttccatgactcagacctg
gctcagttcatgcgcctcttcggtggcaactttgcacatcaggcatcagtagcccgtgtg
gttggacaacagggccggggccgggccgggattgaggccagtctagatgtgcagtacctg
atgagtgctggtgccaacatctccacctgggtctacagtagccctggccggcatgaggga
caggagcccttcctgcagtggctcatgctgctcagtaatgagtcagccctgccacatgtg
catactgtgagctatggagatgatgaggactccctcagcagcgcctacatccagcgggtc
aacactgagctcatgaaggctgccgctcggggtctcaccctgctcttcgcctcaggtgac
agtggggccgggtgttggtctgtctctggaagacaccagttccgccctaccttccctgcc
tccagcccctatgtcaccacagtgggaggcacatccttccaggaacctttcctcatcaca
aatgaaattgttgactatatcagtggtggtggcttcagcaatgtgttcccacggccttca
taccaggaggaagctgtaacgaagttcctgagctctagcccccacctgccaccatccagt
tacttcaatgccagtggccgtgcctacccagatgtggctgcactttctgatggctactgg
gtggtcagcaacagagtgcccattccatgggtgtccggaacctcggcctctactccagtg
tttggggggatcctatccttgatcaatgagcacaggatccttagtggccgcccccctctt
ggctttctcaacccaaggctctaccagcagcatggggcaggactctttgatgtaacccgt
ggctgccatgagtcctgtctggatgaagaggtagagggccagggtttctgctctggtcct
ggctgggatcctgtaacaggctggggaacacccaacttcccagctttgctgaagactcta
ctcaacccctga
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integrated database retrieval system
