Homo sapiens (human): 156
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Entry
156 CDS
T01001
Symbol
GRK2, ADRBK1, BARK1, BETA-ARK1
Name
(RefSeq) G protein-coupled receptor kinase 2
KO
K00910
beta-adrenergic-receptor kinase [EC:
2.7.11.15
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04144
Endocytosis
hsa04340
Hedgehog signaling pathway
hsa04724
Glutamatergic synapse
hsa04740
Olfactory transduction
hsa05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04340 Hedgehog signaling pathway
156 (GRK2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
156 (GRK2)
09150 Organismal Systems
09151 Immune system
04062 Chemokine signaling pathway
156 (GRK2)
09156 Nervous system
04724 Glutamatergic synapse
156 (GRK2)
09157 Sensory system
04740 Olfactory transduction
156 (GRK2)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
156 (GRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
156 (GRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
156 (GRK2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.15 beta-adrenergic-receptor kinase
156 (GRK2)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
GRK family [OT]
156 (GRK2)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
156 (GRK2)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RGS
PH
Kinase-like
Haspin_kinase
DUF5647
HTH_WhiA
Motif
Other DBs
NCBI-GeneID:
156
NCBI-ProteinID:
NP_001610
OMIM:
109635
HGNC:
289
Ensembl:
ENSG00000173020
UniProt:
P25098
A0A0S2Z392
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:67266473..67286556
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AA seq
689 aa
AA seq
DB search
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLVQRGSANGL
NT seq
2070 nt
NT seq
+upstream
nt +downstream
nt
atggcggacctggaggcggtgctggccgacgtgagctacctgatggccatggagaagagc
aaggccacgccggccgcgcgcgccagcaagaagatcctgctgcccgagcccagcatccgc
agtgtcatgcagaagtacctggaggaccggggcgaggtgacctttgagaagatcttttcc
cagaagctggggtacctgctcttccgagacttctgcctgaaccacctggaggaggccagg
cccttggtggaattctatgaggagatcaagaagtacgagaagctggagacggaggaggag
cgtgtggcccgcagccgggagatcttcgactcatacatcatgaaggagctgctggcctgc
tcgcatcccttctcgaagagtgccactgagcatgtccaaggccacctggggaagaagcag
gtgcctccggatctcttccagccatacatcgaagagatttgtcaaaacctccgaggggac
gtgttccagaaattcattgagagcgataagttcacacggttttgccagtggaagaatgtg
gagctcaacatccacctgaccatgaatgacttcagcgtgcatcgcatcattgggcgcggg
ggctttggcgaggtctatgggtgccggaaggctgacacaggcaagatgtacgccatgaag
tgcctggacaaaaagcgcatcaagatgaagcagggggagaccctggccctgaacgagcgc
atcatgctctcgctcgtcagcactggggactgcccattcattgtctgcatgtcatacgcg
ttccacacgccagacaagctcagcttcatcctggacctcatgaacggtggggacctgcac
taccacctctcccagcacggggtcttctcagaggctgacatgcgcttctatgcggccgag
atcatcctgggcctggagcacatgcacaaccgcttcgtggtctaccgggacctgaagcca
gccaacatccttctggacgagcatggccacgtgcggatctcggacctgggcctggcctgt
gacttctccaagaagaagccccatgccagcgtgggcacccacgggtacatggctccggag
gtcctgcagaagggcgtggcctacgacagcagtgccgactggttctctctggggtgcatg
ctcttcaagttgctgcgggggcacagccccttccggcagcacaagaccaaagacaagcat
gagatcgaccgcatgacgctgacgatggccgtggagctgcccgactccttctcccctgaa
ctacgctccctgctggaggggttgctgcagagggatgtcaaccggagattgggctgcctg
ggccgaggggctcaggaggtgaaagagagcccctttttccgctccctggactggcagatg
gtcttcttgcagaagtaccctcccccgctgatccccccacgaggggaggtgaacgcggcc
gacgccttcgacattggctccttcgatgaggaggacacaaaaggaatcaagttactggac
agtgatcaggagctctaccgcaacttccccctcaccatctcggagcggtggcagcaggag
gtggcagagactgtcttcgacaccatcaacgctgagacagaccggctggaggctcgcaag
aaagccaagaacaagcagctgggccatgaggaagactacgccctgggcaaggactgcatc
atgcatggctacatgtccaagatgggcaaccccttcctgacccagtggcagcggcggtac
ttctacctgttccccaaccgcctcgagtggcggggcgagggcgaggccccgcagagcctg
ctgaccatggaggagatccagtcggtggaggagacgcagatcaaggagcgcaagtgcctg
ctcctcaagatccgcggtgggaaacagttcattttgcagtgcgatagcgaccctgagctg
gtgcagtggaagaaggagctgcgcgacgcctaccgcgaggcccagcagctggtgcagcgg
gtgcccaagatgaagaacaagccgcgctcgcccgtggtggagctgagcaaggtgccgctg
gtccagcgcggcagtgccaacggcctctga
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