Homo sapiens (human): 156 Help Entry 156               CDS       T01001                                  Gene name GRK2, ADRBK1, BARK1, BETA-ARK1 Definition (RefSeq) G protein-coupled receptor kinase 2   KO K00910   beta-adrenergic-receptor kinase [EC:2.7.11.15] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04144   Endocytosis hsa04340   Hedgehog signaling pathway hsa04724   Glutamatergic synapse hsa04740   Olfactory transduction hsa05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04340 Hedgehog signaling pathway     156 (GRK2)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     156 (GRK2)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     156 (GRK2)   09156 Nervous system    04724 Glutamatergic synapse     156 (GRK2)   09157 Sensory system    04740 Olfactory transduction     156 (GRK2)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     156 (GRK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     156 (GRK2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     156 (GRK2) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.15  beta-adrenergic-receptor kinase      156 (GRK2) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   GRK family [OT]    156 (GRK2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    156 (GRK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr RGS PH Kinase-like Pkinase_fungal DUF5647 Motif Other DBs NCBI-GeneID:  156 NCBI-ProteinID:  NP_001610 OMIM:  109635 HGNC:  289 Ensembl:  ENSG00000173020 Vega:  OTTHUMG00000167104 Pharos:  P25098(Tbio) UniProt:  P25098 A0A0S2Z392 LinkDB All DBs Structure PDB:  3V5W 5UKL 5WG4 4MK0 4PNK 5UKK 5UVC 5UUU 6C2Y 3CIK 5WG3 3KRW 5WG5 3KRX 5HE1 1BAK Thumbnails Position 11q13.2 AA seq 689 aa AA seqDB search MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR VPKMKNKPRSPVVELSKVPLVQRGSANGL NT seq 2070 nt NT seq  +upstreamnt  +downstreamnt atggcggacctggaggcggtgctggccgacgtgagctacctgatggccatggagaagagc aaggccacgccggccgcgcgcgccagcaagaagatcctgctgcccgagcccagcatccgc agtgtcatgcagaagtacctggaggaccggggcgaggtgacctttgagaagatcttttcc cagaagctggggtacctgctcttccgagacttctgcctgaaccacctggaggaggccagg cccttggtggaattctatgaggagatcaagaagtacgagaagctggagacggaggaggag cgtgtggcccgcagccgggagatcttcgactcatacatcatgaaggagctgctggcctgc tcgcatcccttctcgaagagtgccactgagcatgtccaaggccacctggggaagaagcag gtgcctccggatctcttccagccatacatcgaagagatttgtcaaaacctccgaggggac gtgttccagaaattcattgagagcgataagttcacacggttttgccagtggaagaatgtg gagctcaacatccacctgaccatgaatgacttcagcgtgcatcgcatcattgggcgcggg ggctttggcgaggtctatgggtgccggaaggctgacacaggcaagatgtacgccatgaag tgcctggacaaaaagcgcatcaagatgaagcagggggagaccctggccctgaacgagcgc atcatgctctcgctcgtcagcactggggactgcccattcattgtctgcatgtcatacgcg ttccacacgccagacaagctcagcttcatcctggacctcatgaacggtggggacctgcac taccacctctcccagcacggggtcttctcagaggctgacatgcgcttctatgcggccgag atcatcctgggcctggagcacatgcacaaccgcttcgtggtctaccgggacctgaagcca gccaacatccttctggacgagcatggccacgtgcggatctcggacctgggcctggcctgt gacttctccaagaagaagccccatgccagcgtgggcacccacgggtacatggctccggag gtcctgcagaagggcgtggcctacgacagcagtgccgactggttctctctggggtgcatg ctcttcaagttgctgcgggggcacagccccttccggcagcacaagaccaaagacaagcat gagatcgaccgcatgacgctgacgatggccgtggagctgcccgactccttctcccctgaa ctacgctccctgctggaggggttgctgcagagggatgtcaaccggagattgggctgcctg ggccgaggggctcaggaggtgaaagagagcccctttttccgctccctggactggcagatg gtcttcttgcagaagtaccctcccccgctgatccccccacgaggggaggtgaacgcggcc gacgccttcgacattggctccttcgatgaggaggacacaaaaggaatcaagttactggac agtgatcaggagctctaccgcaacttccccctcaccatctcggagcggtggcagcaggag gtggcagagactgtcttcgacaccatcaacgctgagacagaccggctggaggctcgcaag aaagccaagaacaagcagctgggccatgaggaagactacgccctgggcaaggactgcatc atgcatggctacatgtccaagatgggcaaccccttcctgacccagtggcagcggcggtac ttctacctgttccccaaccgcctcgagtggcggggcgagggcgaggccccgcagagcctg ctgaccatggaggagatccagtcggtggaggagacgcagatcaaggagcgcaagtgcctg ctcctcaagatccgcggtgggaaacagttcattttgcagtgcgatagcgaccctgagctg gtgcagtggaagaaggagctgcgcgacgcctaccgcgaggcccagcagctggtgcagcgg gtgcccaagatgaagaacaagccgcgctcgcccgtggtggagctgagcaaggtgccgctg gtccagcgcggcagtgccaacggcctctga

Homo sapiens (human): 157 Help Entry 157               CDS       T01001                                  Gene name GRK3, ADRBK2, BARK2 Definition (RefSeq) G protein-coupled receptor kinase 3   KO K00910   beta-adrenergic-receptor kinase [EC:2.7.11.15] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04144   Endocytosis hsa04340   Hedgehog signaling pathway hsa04724   Glutamatergic synapse hsa04740   Olfactory transduction hsa05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04340 Hedgehog signaling pathway     157 (GRK3)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     157 (GRK3)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     157 (GRK3)   09156 Nervous system    04724 Glutamatergic synapse     157 (GRK3)   09157 Sensory system    04740 Olfactory transduction     157 (GRK3)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     157 (GRK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     157 (GRK3)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     157 (GRK3) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.15  beta-adrenergic-receptor kinase      157 (GRK3) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   GRK family [OT]    157 (GRK3) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    157 (GRK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr RGS PH Pkinase_fungal HTH_WhiA Kinase-like Motif Other DBs NCBI-GeneID:  157 NCBI-ProteinID:  NP_005151 OMIM:  109636 HGNC:  290 Ensembl:  ENSG00000100077 Vega:  OTTHUMG00000150280 Pharos:  P35626(Tbio) UniProt:  P35626 Q8N433 A0A024R1D8 LinkDB All DBs Position 22q12.1 AA seq 688 aa AA seqDB search MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR APKFLNKPRSGTVELPKPSLCHRNSNGL NT seq 2067 nt NT seq  +upstreamnt  +downstreamnt atggcggacctggaggctgtgctggccgatgtcagttacctgatggccatggagaagagc aaggcgaccccggccgcccgcgccagcaagaggatcgtcctgccggagcccagtatccgg agtgtgatgcagaagtaccttgcagagagaaatgaaataacctttgacaagattttcaat cagaaaattggtttcttgctatttaaagatttttgtttgaatgaaattaatgaagctgta cctcaggtgaagttttatgaagagataaaggaatatgaaaaacttgataatgaggaagac cgcctttgcagaagtcgacaaatttatgatgcctacatcatgaaggaacttctttcctgt tcacatcctttctcaaagcaagctgtagaacacgtacaaagtcatttatccaagaaacaa gtgacatcaactctttttcagccatacatagaagaaatttgtgaaagccttcgaggtgac atttttcaaaaatttatggaaagtgacaagttcactagattttgtcagtggaaaaacgtt gaattaaatatccatttgaccatgaatgagttcagtgtgcataggattattggacgagga ggattcggggaagtttatggttgcaggaaagcagacactggaaaaatgtatgcaatgaaa tgcttagataagaagaggatcaaaatgaaacaaggagaaacattagccttaaatgaaaga atcatgttgtctcttgtcagcacaggagactgtcctttcattgtatgtatgacctatgcc ttccataccccagataaactctgcttcatcctggatctgatgaacgggggcgatttgcac taccacctttcacaacacggtgtgttctctgagaaggagatgcggttttatgccactgaa atcattctgggtctggaacacatgcacaatcggtttgttgtctacagagatttgaagcca gcaaatattctcttggatgaacatggacacgcaagaatatcagatcttggtcttgcctgc gatttttccaaaaagaagcctcatgcgagtgttggcacccatgggtacatggctcccgag gtgctgcagaaggggacggcctatgacagcagtgccgactggttctccctgggctgcatg cttttcaaacttctgagaggtcacagccctttcagacaacataaaaccaaagacaagcat gaaattgaccgaatgacactcaccgtgaatgtggaacttccagacaccttctctcctgaa ctgaagtcccttttggagggcttgcttcagcgagacgttagcaagcggctgggctgtcac ggaggcggctcacaggaagtaaaagagcacagctttttcaaaggtgttgactggcagcat gtctacttacaaaagtacccaccacccttgattcctccccggggagaagtcaatgctgct gatgcctttgatattggctcatttgatgaagaggataccaaagggattaagctacttgat tgcgaccaagaactctacaagaacttccctttggtcatctctgaacgctggcagcaagaa gtaacggaaacagtttatgaagcagtaaatgcagacacagataaaatcgaggccaggaag agagctaaaaataagcaacttggccacgaagaagattacgctctggggaaggactgtatt atgcacgggtacatgctgaaactgggaaacccatttctgactcagtggcagcgtcgctat ttttacctctttccaaatagacttgaatggagaggagagggagagtcccggcaaaattta ctgacaatggaacagattctctctgtggaagaaactcaaattaaagacaaaaaatgcatt ttgttcagaataaaaggagggaaacaatttgtcttgcaatgtgagagtgatccagagttt gtgcagtggaagaaagagttgaacgaaaccttcaaggaggcccagcggctattgcgtcgt gccccgaagttcctcaacaaacctcggtcaggtactgtggagctcccaaagccatccctc tgtcacagaaacagcaacggcctctag

Homo sapiens (human): 2868 Help Entry 2868              CDS       T01001                                  Gene name GRK4, GPRK2L, GPRK4, GRK4a, IT11 Definition (RefSeq) G protein-coupled receptor kinase 4   KO K08291   G protein-coupled receptor kinase [EC:2.7.11.16] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04144   Endocytosis hsa05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     2868 (GRK4)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     2868 (GRK4)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     2868 (GRK4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     2868 (GRK4) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.16  G-protein-coupled receptor kinase      2868 (GRK4) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   GRK family [OT]    2868 (GRK4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr RGS Kinase-like Pkinase_fungal Motif Other DBs NCBI-GeneID:  2868 NCBI-ProteinID:  NP_892027 OMIM:  137026 HGNC:  4543 Ensembl:  ENSG00000125388 Vega:  OTTHUMG00000159914 Pharos:  P32298(Tchem) UniProt:  P32298 LinkDB All DBs Structure PDB:  4YHJ Thumbnails Position 4p16.3 AA seq 578 aa AA seqDB search MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC NT seq 1737 nt NT seq  +upstreamnt  +downstreamnt atggagctcgagaacatcgtggccaactcgctgctgctgaaagcgcgtcaaggaggatat ggcaaaaaaagtggtcgtagtaaaaaatggaaggagatactgacactgcctcctgtcagc cagtgcagtgagcttagacattccattgaaaaggattatagcagtctttgtgacaagcaa ccgataggaagacgtctcttcaggcagttctgtgataccaaacccactctaaagaggcac attgaattcttggatgcagtggcagaatatgaagttgccgatgatgaggaccgaagtgat tgtggactgtcaatcttagatagattcttcaatgataagttggcagcccctttaccagaa atacctccagatgttgtgacagaatgtagattgggactgaaggaggagaacccttccaaa aaagcctttgaggaatgtactagagttgcccataactacctaagaggggaaccatttgaa gaataccaagaaagctcatatttttctcagtttttacaatggaaatggctggaaaggcaa cccgtaacaaagaacacatttagacattacagagttctaggaaaaggcggatttggagag gtttgcgcctgtcaagtgcgagccacaggaaaaatgtatgcctgcaaaaagctacaaaaa aaaagaataaagaagaggaaaggtgaagctatggctctaaatgagaaaagaattctggag aaagtgcaaagtagattcgtagttagtttagcctacgcttatgaaaccaaagatgccttg tgcttggtgctcaccattatgaatggaggggatttgaagtttcacatttacaacctgggc aatcccggctttgatgagcagagagccgttttctatgctgcagagctgtgttgcggcttg gaagatttacagagggaaagaattgtatacagagacttgaagcctgagaatattctcctt gatgatcgtggacacatccggatttcagacctcggtttggccacagagatcccagaagga cagagggttcgaggaagagttggaacagtcggctacatggcacctgaagttgtcaataat gaaaagtatacgtttagtcccgattggtggggacttggctgtctgatctatgaaatgatt cagggacattctccattcaaaaaatacaaagagaaagtcaaatgggaggaggtcgatcaa agaatcaagaatgataccgaggagtattctgagaagttttcagaggatgccaaatctatc tgcaggatgttactcaccaagaatccaagcaagcggctgggctgcaggggcgagggagcg gctggggtgaagcagcaccccgtgttcaaggacatcaacttcaggaggctggaggcaaac atgctggagccccctttctgtcctgatcctcatgccgtttactgtaaggacgtcctggat atcgagcagttctcggtggtgaaagggatctacctggacaccgcagatgaagacttctat gctcggtttgctaccgggtgtgtctccatcccctggcagaatgagatgatcgaatctggg tgtttcaaagacatcaacaaaagtgaaagtgaggaagctttgccattagatctagacaag aacatacataccccggtttccagaccaaacagaggcttcttctatagactcttcagaaga gggggctgcctgaccatggtccccagtgagaaggaagtggaacccaagcaatgctga

Homo sapiens (human): 2869 Help Entry 2869              CDS       T01001                                  Gene name GRK5, FP2025, GPRK5 Definition (RefSeq) G protein-coupled receptor kinase 5   KO K08291   G protein-coupled receptor kinase [EC:2.7.11.16] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04144   Endocytosis hsa05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     2869 (GRK5)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     2869 (GRK5)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     2869 (GRK5)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     2869 (GRK5) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.16  G-protein-coupled receptor kinase      2869 (GRK5) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   GRK family [OT]    2869 (GRK5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr RGS Kinase-like Pkinase_fungal Sulfakinin Motif Other DBs NCBI-GeneID:  2869 NCBI-ProteinID:  NP_005299 OMIM:  600870 HGNC:  4544 Ensembl:  ENSG00000198873 Vega:  OTTHUMG00000019149 Pharos:  P34947(Tbio) UniProt:  P34947 LinkDB All DBs Structure PDB:  4TND 4TNB Thumbnails Position 10q26.11 AA seq 590 aa AA seqDB search MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt atggagctggaaaacatcgtggccaacacggtcttgctgaaagccagggaagggggcgga ggaaagcgcaaagggaaaagcaagaagtggaaagaaatcctgaagttccctcacattagc cagtgtgaagacctccgaaggaccatagacagagattactgcagtttatgtgacaagcag ccaatcgggaggctgcttttccggcagttttgtgaaaccaggcctgggctggagtgttac attcagttcctggactccgtggcagaatatgaagttactccagatgaaaaactgggagag aaagggaaggaaattatgaccaagtacctcaccccaaagtcccctgttttcatagcccaa gttggccaagacctggtctcccagacggaggagaagctcctacagaagccgtgcaaagaa ctcttttctgcctgtgcacagtctgtccacgagtacctgaggggagaaccattccacgaa tatctggacagcatgttttttgaccgctttctccagtggaagtggttggaaaggcaaccg gtgaccaaaaacactttcaggcagtatcgagtgctaggaaaagggggcttcggggaggtc tgtgcctgccaggttcgggccacgggtaaaatgtatgcctgcaagcgcttggagaagaag aggatcaaaaagaggaaaggggagtccatggccctcaatgagaagcagatcctcgagaag gtcaacagtcagtttgtggtcaacctggcctatgcctacgagaccaaggatgcactgtgc ttggtcctgaccatcatgaatgggggtgacctgaagttccacatctacaacatgggcaac cctggcttcgaggaggagcgggccttgttttatgcggcagagatcctctgcggcttagaa gacctccaccgtgagaacaccgtctaccgagatctgaaacctgaaaacatcctgttagat gattatggccacattaggatctcagacctgggcttggctgtgaagatccccgagggagac ctgatccgcggccgggtgggcactgttggctacatggctccagaggtcctgaacaaccag aggtacggcctgagccccgactactggggccttggctgcctcatctatgagatgatcgag ggccagtcgccgttccgcggccgcaaggagaaggtgaagcgggaggaggtggaccgccgg gtcctggagacggaggaggtgtactcccacaagttctccgaggaggccaagtccatctgc aagatgctgctcacgaaagatgcgaagcagaggctgggctgccaggaggagggggctgca gaggtcaagagacaccccttcttcaggaacatgaacttcaagcgcttagaagccgggatg ttggaccctcccttcgttccagacccccgcgctgtgtactgtaaggacgtgctggacatc gagcagttctccactgtgaagggcgtcaatctggaccacacagacgacgacttctactcc aagttctccacgggctctgtgtccatcccatggcaaaacgagatgatagaaacagaatgc tttaaggagctgaacgtgtttggacctaatggtaccctcccgccagatctgaacagaaac caccctccggaaccgcccaagaaagggctgctccagagactcttcaagcggcagcatcag aacaattccaagagttcgcccagctccaagaccagttttaaccaccacataaactcaaac catgtcagctcgaactccaccggaagcagctag

Homo sapiens (human): 2870 Help Entry 2870              CDS       T01001                                  Gene name GRK6, GPRK6 Definition (RefSeq) G protein-coupled receptor kinase 6   KO K08291   G protein-coupled receptor kinase [EC:2.7.11.16] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04144   Endocytosis hsa05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     2870 (GRK6)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     2870 (GRK6)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     2870 (GRK6)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     2870 (GRK6) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.16  G-protein-coupled receptor kinase      2870 (GRK6) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   GRK family [OT]    2870 (GRK6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr RGS Kinase-like Pkinase_fungal Motif Other DBs NCBI-GeneID:  2870 NCBI-ProteinID:  NP_001004106 OMIM:  600869 HGNC:  4545 Ensembl:  ENSG00000198055 Vega:  OTTHUMG00000163401 Pharos:  P43250(Tbio) UniProt:  P43250 LinkDB All DBs Structure PDB:  2ACX 3NYN 3NYO Thumbnails Position 5q35.3 AA seq 576 aa AA seqDB search MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL NT seq 1731 nt NT seq  +upstreamnt  +downstreamnt atggagctcgagaacatcgtagcgaacacggtgctactcaaggcccgggaaggtggcggt ggaaatcgcaaaggcaaaagcaagaaatggcggcagatgctccagttccctcacatcagc cagtgcgaagagctgcggctcagcctcgagcgtgactatcacagcctgtgcgagcggcag cccattgggcgcctgctgttccgagagttctgtgccacgaggccggagctgagccgctgc gtcgccttcctggatggggtggccgagtatgaagtgaccccggatgacaagcggaaggca tgtgggcggcagctaacgcagaattttctgagccacacgggtcctgacctcatccctgag gtcccccggcagctggtgacgaactgcacccagcggctggagcagggtccctgcaaagac cttttccaggaactcacccggctgacccacgagtacctgagcgtggccccttttgccgac tacctcgacagcatctacttcaaccgtttcctgcagtggaagtggctggaaaggcagcca gtgaccaaaaacaccttcaggcaataccgagtcctgggcaaaggtggctttggggaggtg tgcgcctgccaggtgcgggccacaggtaagatgtatgcctgcaagaagctagagaaaaag cggatcaagaagcggaaaggggaggccatggcgctgaacgagaagcagatcctggagaaa gtgaacagtaggtttgtagtgagcttggcctacgcctatgagaccaaggacgcgctgtgc ctggtgctgacactgatgaacgggggcgacctcaagttccacatctaccacatgggccag gctggcttccccgaagcgcgggccgtcttctacgccgccgagatctgctgtggcctggag gacctgcaccgggagcgcatcgtgtacagggacctgaagcccgagaacatcttgctggat gaccacggccacatccgcatctctgacctgggactagctgtgcatgtgcccgagggccag accatcaaagggcgtgtgggcaccgtgggttacatggctccggaggtggtgaagaatgaa cggtacacgttcagccctgactggtgggcgctcggctgcctcctgtacgagatgatcgca ggccagtcgcccttccagcagaggaagaagaagatcaagcgggaggaggtggagcggctg gtgaaggaggtccccgaggagtattccgagcgcttttccccgcaggcccgctcactttgc tcacagctcctctgcaaggaccctgccgaacgcctggggtgtcgtgggggcagtgcccgc gaggtgaaggagcaccccctctttaagaagctgaacttcaagcggctgggagctggcatg ctggagccgccgttcaagcctgacccccaggccatttactgcaaggatgttctggacatt gaacagttctctacggtcaagggcgtggagctggagcctaccgaccaggacttctaccag aagtttgccacaggcagtgtgcccatcccctggcagaacgagatggtggagaccgagtgc ttccaagagctgaatgtctttgggctggatggctcagttcccccagacctggactggaag ggccagccacctgcacctcctaaaaagggactgctgcagagactcttcagtcgccaagat tgctgtggaaactgcagcgacagcgaggaagagctccccacccgcctctag

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